ENSG00000169660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337014 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding protein_coding 20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 4.5061312 7.052525 1.7924574 0.22858009 0.16157325 -1.9702190 0.21394167 0.2455333 0.16673333 -0.07880000 2.154201e-01 1.991539e-06 FALSE TRUE
ENST00000581482 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding nonsense_mediated_decay 20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 0.5323073 0.000000 0.6785610 0.00000000 0.45631687 6.1055125 0.03325833 0.0000000 0.05763333 0.05763333 1.776892e-01 1.991539e-06 FALSE FALSE
ENST00000583978 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding retained_intron 20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 3.3994518 3.612086 2.6996769 0.52671916 0.23010159 -0.4186999 0.18894167 0.1257667 0.25113333 0.12536667 7.287373e-02 1.991539e-06   FALSE
ENST00000585077 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding retained_intron 20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 1.4470536 1.852513 1.4564439 1.12411677 0.26829692 -0.3449284 0.07899583 0.0656000 0.13236667 0.06676667 7.596563e-01 1.991539e-06 FALSE TRUE
ENST00000644009 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding protein_coding 20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 3.1236233 5.840914 0.0000000 2.00461370 0.00000000 -9.1925183 0.11083333 0.2037000 0.00000000 -0.20370000 1.991539e-06 1.991539e-06 FALSE TRUE
ENST00000644886 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding retained_intron 20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 2.4051815 3.258526 1.9354454 0.90589367 0.18930664 -0.7485396 0.13043750 0.1133667 0.18226667 0.06890000 6.155697e-01 1.991539e-06 FALSE TRUE
MSTRG.15351.14 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding   20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 1.2136011 2.128209 0.5598180 1.07979970 0.30435034 -1.9078300 0.06177500 0.0734000 0.05603333 -0.01736667 9.965346e-01 1.991539e-06 TRUE TRUE
MSTRG.15351.23 ENSG00000169660 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXD protein_coding   20.39204 28.70815 10.82616 0.5618042 0.7387528 -1.406109 1.1881383 1.420552 0.6651137 0.09419748 0.04116023 -1.0833695 0.05751250 0.0494000 0.06146667 0.01206667 7.888405e-01 1.991539e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169660 E001 0.000000       17 82418318 82418346 29 +      
ENSG00000169660 E002 27.206683 0.0021762629 5.998991e-05 0.0009736851 17 82418347 82418660 314 + 0.997 1.386 1.385
ENSG00000169660 E003 6.077968 0.0053892902 1.591788e-01 0.3755414496 17 82418661 82418672 12 + 0.574 0.788 0.904
ENSG00000169660 E004 8.125168 0.0053650787 1.730843e-01 0.3946045846 17 82418673 82418686 14 + 0.710 0.892 0.721
ENSG00000169660 E005 7.577685 0.0164386641 2.656434e-01 0.5050347071 17 82418687 82418689 3 + 0.710 0.864 0.615
ENSG00000169660 E006 7.839422 0.0266827366 2.466183e-01 0.4843075167 17 82418690 82418696 7 + 0.710 0.880 0.674
ENSG00000169660 E007 9.023750 0.0121589818 1.010119e-01 0.2836239660 17 82418697 82418712 16 + 0.710 0.938 0.897
ENSG00000169660 E008 9.196124 0.0070353725 8.195425e-02 0.2486566549 17 82418713 82418715 3 + 0.710 0.947 0.928
ENSG00000169660 E009 13.391720 0.0041323346 5.962399e-01 0.7678243112 17 82418716 82418740 25 + 1.026 1.063 0.135
ENSG00000169660 E010 31.484155 0.0037176609 9.512668e-01 0.9776268159 17 82419749 82419799 51 + 1.422 1.400 -0.075
ENSG00000169660 E011 72.738223 0.0108923126 6.744746e-01 0.8191867521 17 82419800 82419883 84 + 1.803 1.742 -0.207
ENSG00000169660 E012 44.820220 0.0256992415 2.300757e-05 0.0004308319 17 82419884 82420296 413 + 1.861 1.435 -1.449
ENSG00000169660 E013 27.225118 0.0202586576 2.850369e-05 0.0005163288 17 82420297 82420496 200 + 1.653 1.220 -1.498
ENSG00000169660 E014 4.044707 0.0174460657 5.384695e-01 0.7279589472 17 82423310 82423599 290 + 0.710 0.588 -0.524
ENSG00000169660 E015 47.423774 0.0258962011 8.975144e-01 0.9505713726 17 82424394 82424418 25 + 1.608 1.560 -0.165
ENSG00000169660 E016 88.756321 0.0059600713 5.147626e-01 0.7114948948 17 82424419 82424503 85 + 1.892 1.822 -0.234
ENSG00000169660 E017 1.783438 0.0110397095 5.083932e-01 0.7067754294 17 82428030 82428127 98 + 0.486 0.345 -0.769
ENSG00000169660 E018 103.839824 0.0004313701 5.614107e-01 0.7442722702 17 82428558 82428645 88 + 1.949 1.897 -0.175
ENSG00000169660 E019 113.207064 0.0004423963 3.556152e-01 0.5922162491 17 82433658 82433799 142 + 1.936 1.947 0.039
ENSG00000169660 E020 64.342754 0.0008661175 9.790645e-02 0.2781251422 17 82433800 82433822 23 + 1.646 1.715 0.232
ENSG00000169660 E021 133.383614 0.0026703022 1.125204e-02 0.0634119171 17 82435689 82435872 184 + 1.939 2.027 0.294
ENSG00000169660 E022 83.528160 0.0057384468 8.636648e-04 0.0088005611 17 82436667 82436728 62 + 1.653 1.837 0.624
ENSG00000169660 E023 52.663346 0.0019337464 4.269441e-02 0.1617583006 17 82436729 82436738 10 + 1.523 1.630 0.368
ENSG00000169660 E024 42.958427 0.0414105347 1.840597e-02 0.0903737389 17 82436739 82437126 388 + 1.735 1.470 -0.904
ENSG00000169660 E025 17.946942 0.0456120408 8.463503e-02 0.2540157870 17 82437127 82437167 41 + 1.359 1.117 -0.853
ENSG00000169660 E026 83.774058 0.0011104514 1.024436e-02 0.0591643750 17 82437168 82437214 47 + 1.721 1.829 0.365
ENSG00000169660 E027 122.643601 0.0035844275 5.247670e-02 0.1854180947 17 82437215 82437363 149 + 1.922 1.989 0.224
ENSG00000169660 E028 88.279297 0.0007247562 5.902855e-02 0.2005763687 17 82439631 82439713 83 + 1.784 1.850 0.224
ENSG00000169660 E029 48.088371 0.0958932662 6.323906e-02 0.2099886135 17 82439714 82439999 286 + 1.770 1.521 -0.845
ENSG00000169660 E030 34.183014 0.0896152083 6.258569e-02 0.2085776281 17 82440000 82440113 114 + 1.633 1.376 -0.883
ENSG00000169660 E031 28.666198 0.1356806623 2.407336e-01 0.4774173668 17 82440114 82440173 60 + 1.492 1.327 -0.573
ENSG00000169660 E032 24.597113 0.0620668374 2.828229e-01 0.5232634218 17 82440174 82440262 89 + 1.412 1.271 -0.493
ENSG00000169660 E033 22.144911 0.0427930403 2.002232e-01 0.4299992736 17 82440263 82440334 72 + 1.386 1.220 -0.579
ENSG00000169660 E034 27.830971 0.0716014650 1.689012e-01 0.3891162130 17 82440335 82440472 138 + 1.507 1.304 -0.704
ENSG00000169660 E035 36.153556 0.0354462867 3.602067e-02 0.1442891613 17 82440473 82440613 141 + 1.643 1.400 -0.832
ENSG00000169660 E036 107.359584 0.0005205376 4.264501e-01 0.6483598615 17 82440997 82441070 74 + 1.915 1.922 0.026
ENSG00000169660 E037 61.198036 0.0192730449 9.938322e-01 0.9985524127 17 82441071 82441075 5 + 1.701 1.673 -0.097
ENSG00000169660 E038 47.230933 0.0142411807 9.314172e-01 0.9677868837 17 82441076 82441152 77 + 1.583 1.566 -0.060
ENSG00000169660 E039 31.952884 0.0011230659 8.303359e-01 0.9139706265 17 82441153 82441164 12 + 1.444 1.402 -0.147
ENSG00000169660 E040 117.543523 0.0050599877 5.000351e-01 0.7007766159 17 82441165 82441266 102 + 1.953 1.962 0.029
ENSG00000169660 E041 11.584898 0.0026099649 6.992685e-01 0.8350996245 17 82441744 82441799 56 + 1.054 0.983 -0.258
ENSG00000169660 E042 72.521601 0.0264096845 9.959411e-01 0.9995867510 17 82441800 82441820 21 + 1.782 1.746 -0.123
ENSG00000169660 E043 110.647640 0.0004675696 8.782745e-01 0.9404237560 17 82441821 82441889 69 + 1.953 1.932 -0.070
ENSG00000169660 E044 177.440184 0.0034272654 1.021495e-01 0.2856139910 17 82442177 82442645 469 + 2.105 2.145 0.134