ENSG00000169609

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304177 ENSG00000169609 HEK293_OSMI2_6hA HEK293_TMG_6hB C15orf40 protein_coding protein_coding 40.51739 29.5125 40.37752 5.117563 2.647194 0.4520946 1.890126 1.941626 2.083030 0.1481106 0.08281303 0.1009164 0.05122083 0.06966667 0.05176667 -0.017900000 0.74565033 0.01172144 FALSE TRUE
ENST00000505341 ENSG00000169609 HEK293_OSMI2_6hA HEK293_TMG_6hB C15orf40 protein_coding retained_intron 40.51739 29.5125 40.37752 5.117563 2.647194 0.4520946 2.116518 1.446616 2.059635 0.2218137 0.13900957 0.5067554 0.05124583 0.05036667 0.05126667 0.000900000 0.99775070 0.01172144   FALSE
ENST00000508990 ENSG00000169609 HEK293_OSMI2_6hA HEK293_TMG_6hB C15orf40 protein_coding protein_coding 40.51739 29.5125 40.37752 5.117563 2.647194 0.4520946 6.956752 3.362536 9.359304 0.9501676 1.12087774 1.4741081 0.17735000 0.10956667 0.23086667 0.121300000 0.01172144 0.01172144 FALSE TRUE
ENST00000565712 ENSG00000169609 HEK293_OSMI2_6hA HEK293_TMG_6hB C15orf40 protein_coding protein_coding 40.51739 29.5125 40.37752 5.117563 2.647194 0.4520946 5.927130 3.553635 4.382493 1.4306506 0.20853567 0.3016906 0.13767500 0.11086667 0.10913333 -0.001733333 0.99756866 0.01172144   FALSE
MSTRG.11412.10 ENSG00000169609 HEK293_OSMI2_6hA HEK293_TMG_6hB C15orf40 protein_coding   40.51739 29.5125 40.37752 5.117563 2.647194 0.4520946 14.161168 11.163904 11.429161 2.2799372 2.08163491 0.0338479 0.33539583 0.37463333 0.28216667 -0.092466667 0.56152626 0.01172144 FALSE TRUE
MSTRG.11412.15 ENSG00000169609 HEK293_OSMI2_6hA HEK293_TMG_6hB C15orf40 protein_coding   40.51739 29.5125 40.37752 5.117563 2.647194 0.4520946 2.923204 2.159636 3.784677 0.1971781 0.85653064 0.8065239 0.07847083 0.07950000 0.09293333 0.013433333 0.92202304 0.01172144 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169609 E001 2.562370 0.0825456419 1.717149e-01 3.928274e-01 15 82988046 82988440 395 - 0.402 0.677 1.302
ENSG00000169609 E002 5.707716 0.2535706873 3.156072e-01 5.556088e-01 15 82988441 82988531 91 - 0.701 0.935 0.923
ENSG00000169609 E003 5.848672 0.0574030029 1.626835e-01 3.807429e-01 15 82988532 82988556 25 - 0.694 0.949 0.999
ENSG00000169609 E004 35.547416 0.0172094311 1.141831e-06 3.186674e-05 15 82988557 82988828 272 - 1.289 1.748 1.574
ENSG00000169609 E005 3.199700 0.0459961159 2.329090e-01 4.684913e-01 15 82988963 82989105 143 - 0.492 0.715 0.994
ENSG00000169609 E006 2.956455 0.0998330568 8.807513e-01 9.416331e-01 15 82989106 82989157 52 - 0.601 0.581 -0.092
ENSG00000169609 E007 2.072946 0.0100238939 1.322048e-01 3.352960e-01 15 82990561 82990618 58 - 0.344 0.613 1.363
ENSG00000169609 E008 2.275680 0.0098752515 8.360957e-02 2.520070e-01 15 82990619 82990655 37 - 0.344 0.648 1.516
ENSG00000169609 E009 3.862354 0.0066928738 8.814174e-03 5.299708e-02 15 82991932 82991955 24 - 0.449 0.858 1.779
ENSG00000169609 E010 6.658916 0.0044628363 7.409762e-04 7.788253e-03 15 82991956 82992046 91 - 0.604 1.055 1.779
ENSG00000169609 E011 2.706723 0.1240728454 3.751748e-01 6.083270e-01 15 82992047 82992048 2 - 0.451 0.652 0.936
ENSG00000169609 E012 22.474498 0.0261022197 9.374177e-01 9.709040e-01 15 82994817 82995338 522 - 1.358 1.374 0.055
ENSG00000169609 E013 9.722743 0.0034488618 1.759798e-01 3.984296e-01 15 82995339 82995384 46 - 1.085 0.967 -0.434
ENSG00000169609 E014 263.645829 0.0228889311 2.759344e-01 5.160054e-01 15 82995385 83004685 9301 - 2.372 2.473 0.336
ENSG00000169609 E015 38.024781 0.0012429783 9.857373e-06 2.071280e-04 15 83004686 83004866 181 - 1.684 1.451 -0.797
ENSG00000169609 E016 67.585643 0.0005995947 2.408067e-09 1.304450e-07 15 83004867 83004972 106 - 1.930 1.696 -0.791
ENSG00000169609 E017 69.613332 0.0014902254 2.472734e-06 6.288217e-05 15 83004973 83005278 306 - 1.926 1.739 -0.630
ENSG00000169609 E018 19.520220 0.0032507894 1.775201e-01 4.004618e-01 15 83005279 83005297 19 - 1.351 1.269 -0.288
ENSG00000169609 E019 194.002165 0.0105254875 7.625696e-01 8.741251e-01 15 83005298 83005692 395 - 2.279 2.297 0.061
ENSG00000169609 E020 20.258659 0.0406765800 6.894619e-01 8.286770e-01 15 83006828 83007031 204 - 1.332 1.319 -0.047
ENSG00000169609 E021 20.684737 0.0495855540 6.662985e-01 8.138850e-01 15 83007851 83008404 554 - 1.288 1.384 0.334
ENSG00000169609 E022 7.808264 0.2619460681 8.232008e-01 9.098025e-01 15 83008405 83008547 143 - 0.900 0.988 0.329
ENSG00000169609 E023 223.161738 0.0066402818 8.146813e-01 9.050292e-01 15 83008548 83008675 128 - 2.338 2.358 0.068
ENSG00000169609 E024 251.157959 0.0005709831 5.265560e-01 7.195500e-01 15 83010237 83010363 127 - 2.391 2.404 0.041
ENSG00000169609 E025 17.284131 0.1691729256 9.383619e-01 9.714793e-01 15 83010364 83011485 1122 - 1.214 1.308 0.330
ENSG00000169609 E026 6.691743 0.0602894895 4.925096e-01 6.956915e-01 15 83011486 83011496 11 - 0.919 0.838 -0.310
ENSG00000169609 E027 154.765320 0.0015567650 4.533325e-01 6.682316e-01 15 83011497 83011670 174 - 2.162 2.213 0.170