ENSG00000169249

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307771 ENSG00000169249 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRSR2 protein_coding protein_coding 10.26632 10.48571 10.22979 1.287955 0.3043105 -0.03561286 6.2454070 6.5521406 6.174278 1.3048364 0.57201503 -0.08556144 0.6077625 0.61260000 0.60440000 -0.00820000 1.00000000 0.02397277 FALSE  
ENST00000380308 ENSG00000169249 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRSR2 protein_coding protein_coding 10.26632 10.48571 10.22979 1.287955 0.3043105 -0.03561286 1.1899919 0.5349997 1.365514 0.1575662 0.06449452 1.33564381 0.1149958 0.05040000 0.13336667 0.08296667 0.02397277 0.02397277 FALSE  
MSTRG.33926.3 ENSG00000169249 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRSR2 protein_coding   10.26632 10.48571 10.22979 1.287955 0.3043105 -0.03561286 1.5300259 1.9894196 1.129292 0.2005175 0.56821877 -0.81144398 0.1493833 0.19400000 0.10860000 -0.08540000 0.78364975 0.02397277 FALSE  
MSTRG.33926.9 ENSG00000169249 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRSR2 protein_coding   10.26632 10.48571 10.22979 1.287955 0.3043105 -0.03561286 0.5829397 0.7553640 0.687127 0.2799485 0.23077259 -0.13472450 0.0584125 0.07936667 0.06663333 -0.01273333 1.00000000 0.02397277 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169249 E001 4.1684110 0.0263807382 2.258741e-01 4.604187e-01 X 15790156 15790302 147 + 0.809 0.619 -0.785
ENSG00000169249 E002 2.6706514 0.0084726613 4.940067e-01 6.966928e-01 X 15790303 15790435 133 + 0.630 0.518 -0.507
ENSG00000169249 E003 2.6844431 0.0079505711 4.941214e-01 6.967623e-01 X 15790436 15790470 35 + 0.629 0.518 -0.506
ENSG00000169249 E004 2.2329565 0.0092610510 6.877039e-01 8.275989e-01 X 15790471 15790471 1 + 0.548 0.479 -0.335
ENSG00000169249 E005 10.0916841 0.0362904638 1.952558e-01 4.236574e-01 X 15790472 15790483 12 + 1.143 0.956 -0.682
ENSG00000169249 E006 22.2813024 0.0267258983 4.790881e-01 6.865044e-01 X 15790484 15790511 28 + 1.416 1.328 -0.304
ENSG00000169249 E007 28.9184745 0.0018864227 8.550070e-02 2.555301e-01 X 15790512 15790536 25 + 1.540 1.424 -0.399
ENSG00000169249 E008 1.2782017 0.0261039196 1.904459e-01   X 15790865 15790933 69 + 0.237 0.476 1.458
ENSG00000169249 E009 49.0859754 0.0007816300 2.416858e-02 1.096022e-01 X 15790934 15791013 80 + 1.760 1.644 -0.392
ENSG00000169249 E010 3.6288842 0.0072170618 7.046200e-03 4.484697e-02 X 15796142 15796165 24 + 0.389 0.810 1.912
ENSG00000169249 E011 4.8034365 0.0100824499 1.160936e-01 3.093236e-01 X 15796166 15796250 85 + 0.629 0.847 0.888
ENSG00000169249 E012 37.3610114 0.0024741910 5.824333e-01 7.586568e-01 X 15799872 15799882 11 + 1.603 1.564 -0.134
ENSG00000169249 E013 67.3203497 0.0012375849 2.387695e-02 1.087036e-01 X 15799883 15799953 71 + 1.887 1.783 -0.350
ENSG00000169249 E014 9.6858558 0.0036366667 1.712621e-04 2.348344e-03 X 15801274 15801790 517 + 1.200 0.791 -1.522
ENSG00000169249 E015 69.5444124 0.0006049960 1.530136e-01 3.666398e-01 X 15803688 15803796 109 + 1.816 1.870 0.182
ENSG00000169249 E016 60.1720665 0.0024045070 3.594790e-02 1.440758e-01 X 15804111 15804197 87 + 1.726 1.825 0.334
ENSG00000169249 E017 42.7999024 0.0010824337 4.620350e-03 3.257802e-02 X 15808233 15808271 39 + 1.545 1.695 0.510
ENSG00000169249 E018 60.0641451 0.0007504270 3.978419e-02 1.541788e-01 X 15809200 15809318 119 + 1.729 1.817 0.298
ENSG00000169249 E019 88.9574901 0.0021339281 2.286860e-01 4.636875e-01 X 15815677 15815890 214 + 1.923 1.966 0.146
ENSG00000169249 E020 47.3476986 0.0009505550 1.732820e-01 3.948729e-01 X 15818587 15818642 56 + 1.641 1.705 0.217
ENSG00000169249 E021 62.2487982 0.0011126262 2.788678e-02 1.209696e-01 X 15820207 15820316 110 + 1.740 1.834 0.317
ENSG00000169249 E022 47.2037737 0.0007543252 1.747727e-01 3.968669e-01 X 15822731 15822844 114 + 1.720 1.647 -0.247
ENSG00000169249 E023 80.1237814 0.0007486958 8.525602e-01 9.264971e-01 X 15822845 15823196 352 + 1.909 1.912 0.009
ENSG00000169249 E024 7.0061739 0.0997682937 3.278280e-01 5.668922e-01 X 15823197 15823201 5 + 0.786 0.988 0.774
ENSG00000169249 E025 5.9607766 0.0715766305 7.573862e-01 8.710718e-01 X 15823202 15823260 59 + 0.809 0.884 0.289
ENSG00000169249 E026 1.9791624 0.2207879517 9.651629e-01 9.844907e-01 X 15824242 15824372 131 + 0.501 0.468 -0.163
ENSG00000169249 E027 0.1779838 0.0341346886 4.001153e-01   X 15824373 15825718 1346 + 0.134 0.000 -9.663
ENSG00000169249 E028 17.9122261 0.0389866240 2.875612e-08 1.215393e-06 X 15827189 15830694 3506 + 1.538 0.808 -2.627