ENSG00000169062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351487 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding protein_coding 13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 2.0494863 2.0329886 3.323381 0.2772370 0.39805018 0.7063049 0.15807083 0.18710000 0.21630000 0.029200000 0.91266384 0.01033273 FALSE TRUE
ENST00000375299 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding protein_coding 13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 1.6284422 1.4530121 1.883114 0.1996871 0.59341059 0.3718192 0.12352083 0.13556667 0.11823333 -0.017333333 0.93173604 0.01033273 FALSE TRUE
ENST00000475218 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding processed_transcript 13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 1.3057769 0.9191038 1.325682 0.4634963 0.05202872 0.5236647 0.09865000 0.07950000 0.08506667 0.005566667 0.91992485 0.01033273 FALSE TRUE
ENST00000492270 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding protein_coding 13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 2.2382656 2.8364097 1.574785 0.6353779 0.27268481 -0.8448560 0.18030833 0.25416667 0.10003333 -0.154133333 0.01033273 0.01033273 FALSE TRUE
ENST00000618700 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding retained_intron 13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 0.7361213 0.4729314 1.460923 0.2179682 0.36659016 1.6068313 0.05245417 0.04450000 0.09283333 0.048333333 0.51598050 0.01033273 FALSE TRUE
ENST00000619079 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding retained_intron 13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 1.1441204 0.6662859 1.730042 0.1558105 0.07531297 1.3634172 0.08484583 0.06240000 0.11103333 0.048633333 0.35976227 0.01033273 FALSE FALSE
MSTRG.9117.12 ENSG00000169062 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3A protein_coding   13.18967 10.90968 15.59984 0.9440763 0.6968007 0.5155251 1.1833711 0.7853969 1.041772 0.2367378 0.52187115 0.4030755 0.08724167 0.07516667 0.06936667 -0.005800000 0.94101411 0.01033273 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169062 E001 0.9512337 0.0860165414 0.0069674019   13 114281601 114281602 2 + 0.000 0.492 11.762
ENSG00000169062 E002 9.1988189 0.0034476984 0.0001362973 0.001936776 13 114281603 114281627 25 + 0.781 1.178 1.481
ENSG00000169062 E003 10.0756703 0.0036874563 0.0002362981 0.003071477 13 114281628 114281634 7 + 0.840 1.207 1.350
ENSG00000169062 E004 10.3491731 0.0037878595 0.0002767208 0.003495764 13 114281635 114281636 2 + 0.858 1.216 1.312
ENSG00000169062 E005 11.1779812 0.0036226089 0.0002336290 0.003041906 13 114281637 114281644 8 + 0.893 1.243 1.276
ENSG00000169062 E006 23.8838760 0.0025396222 0.0002056268 0.002736690 13 114281645 114281719 75 + 1.267 1.513 0.853
ENSG00000169062 E007 35.9135829 0.0017736406 0.0007238003 0.007643675 13 114281720 114281846 127 + 1.478 1.655 0.607
ENSG00000169062 E008 0.8136113 0.0191641969 0.2590397081   13 114281925 114281952 28 + 0.339 0.131 -1.752
ENSG00000169062 E009 5.1204396 0.0509978190 0.3129082872 0.553237593 13 114281953 114282020 68 + 0.713 0.845 0.525
ENSG00000169062 E010 31.9958320 0.0014810621 0.0727271258 0.230239522 13 114282021 114282127 107 + 1.477 1.566 0.304
ENSG00000169062 E011 10.1889566 0.0095627566 0.0167944644 0.084708621 13 114282128 114282270 143 + 0.925 1.166 0.880
ENSG00000169062 E012 7.5118557 0.1228713950 0.9858178803 0.994741585 13 114282405 114282652 248 + 0.920 0.935 0.054
ENSG00000169062 E013 36.1069429 0.0051480073 0.0570670982 0.196203671 13 114282837 114282943 107 + 1.630 1.481 -0.510
ENSG00000169062 E014 25.0950115 0.1169480404 0.0474213607 0.173561158 13 114282944 114283729 786 + 1.536 1.205 -1.151
ENSG00000169062 E015 28.3598588 0.0812979402 0.0196669582 0.094778565 13 114285077 114285974 898 + 1.586 1.265 -1.109
ENSG00000169062 E016 15.4563872 0.2850949742 0.0521465879 0.184739861 13 114285975 114286258 284 + 1.345 0.988 -1.274
ENSG00000169062 E017 8.9554220 0.1737116292 0.1102252566 0.299354863 13 114286259 114286301 43 + 1.114 0.805 -1.154
ENSG00000169062 E018 27.8603104 0.0017624327 0.0033544050 0.025503901 13 114286302 114286373 72 + 1.545 1.323 -0.763
ENSG00000169062 E019 16.6087956 0.0026013957 0.1055178779 0.291518694 13 114286374 114286384 11 + 1.306 1.147 -0.564
ENSG00000169062 E020 16.4869648 0.0023436782 0.2983529584 0.538789167 13 114286385 114286400 16 + 1.287 1.178 -0.383
ENSG00000169062 E021 5.7920766 0.0058279168 0.0131373400 0.071013901 13 114286401 114286518 118 + 0.968 0.619 -1.391
ENSG00000169062 E022 42.7523943 0.0071651370 0.8658457639 0.933661772 13 114286519 114286629 111 + 1.644 1.632 -0.039
ENSG00000169062 E023 26.7730014 0.0016641627 0.6709437605 0.816951378 13 114286630 114287312 683 + 1.464 1.415 -0.171
ENSG00000169062 E024 13.9782046 0.0061350533 0.9908508361 0.997161775 13 114287313 114287617 305 + 1.182 1.158 -0.083
ENSG00000169062 E025 24.0241230 0.0027943533 0.9567741247 0.980240334 13 114291489 114291544 56 + 1.408 1.384 -0.084
ENSG00000169062 E026 0.6536007 0.0202210297 0.2232483341   13 114291605 114291633 29 + 0.113 0.313 1.831
ENSG00000169062 E027 37.7919337 0.0059564276 0.5876521274 0.762094568 13 114291634 114291792 159 + 1.578 1.591 0.043
ENSG00000169062 E028 48.6415441 0.0007606379 0.1631041588 0.381342845 13 114298840 114299000 161 + 1.674 1.721 0.161
ENSG00000169062 E029 60.1851708 0.0007852140 0.2282040906 0.463176243 13 114301731 114301867 137 + 1.773 1.806 0.109
ENSG00000169062 E030 53.1802164 0.0008093320 0.4212334968 0.644565210 13 114301868 114302025 158 + 1.760 1.701 -0.200
ENSG00000169062 E031 137.8545614 0.0005974940 0.1486936722 0.360397418 13 114304789 114305817 1029 + 2.171 2.108 -0.210