ENSG00000168944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306467 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding protein_coding 4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 0.44006351 0.54861076 0.82800672 0.13750738 0.828006725 0.5851184 0.1338083 0.4295333 0.107100000 -0.322433333 0.2554717967 0.0004463436 FALSE TRUE
ENST00000306481 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding protein_coding 4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 0.61921238 0.26065856 2.82419253 0.26065856 1.413583198 3.3883918 0.1465542 0.1775000 0.364433333 0.186933333 0.7337976876 0.0004463436 FALSE TRUE
ENST00000328236 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding protein_coding 4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 0.98061909 0.36755264 0.90561555 0.36755264 0.905615548 1.2780642 0.1735000 0.2352333 0.117133333 -0.118100000 0.9129452700 0.0004463436 FALSE TRUE
ENST00000675330 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding protein_coding 4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 0.21212557 0.00000000 0.15507931 0.00000000 0.005609983 4.0450874 0.0513750 0.0000000 0.020033333 0.020033333 0.3728069872 0.0004463436 FALSE TRUE
ENST00000675564 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding retained_intron 4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 0.15736371 0.00000000 0.00000000 0.00000000 0.000000000 0.0000000 0.1016333 0.0000000 0.000000000 0.000000000   0.0004463436 FALSE TRUE
ENST00000676068 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding retained_intron 4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 0.09998271 0.00000000 0.02339842 0.00000000 0.023398417 1.7397797 0.0510500 0.0000000 0.003033333 0.003033333 1.0000000000 0.0004463436 FALSE TRUE
MSTRG.26823.1 ENSG00000168944 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP120 protein_coding   4.22062 1.378797 7.742951 0.1393462 0.0103312 2.48091 1.09383381 0.03494615 2.20356080 0.03494615 0.259128868 5.6220277 0.1635333 0.0238000 0.284600000 0.260800000 0.0004463436 0.0004463436 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168944 E001 1.1727720 0.0787494954 5.438456e-01   5 123344146 123344258 113 - 0.249 0.372 0.814
ENSG00000168944 E002 0.0000000       5 123344890 123344891 2 -      
ENSG00000168944 E003 0.3336024 0.0274424043 1.766316e-02   5 123344892 123344894 3 - 0.000 0.370 15.592
ENSG00000168944 E004 0.3336024 0.0274424043 1.766316e-02   5 123344895 123344907 13 - 0.000 0.370 15.592
ENSG00000168944 E005 4.5388471 0.0378682787 1.366331e-01 3.423497e-01 5 123344908 123345002 95 - 0.596 0.849 1.042
ENSG00000168944 E006 104.9821436 0.0008165933 3.793052e-07 1.212855e-05 5 123345003 123346399 1397 - 1.873 2.074 0.675
ENSG00000168944 E007 31.4893361 0.0011723725 4.904215e-01 6.943008e-01 5 123346400 123346604 205 - 1.399 1.455 0.193
ENSG00000168944 E008 44.5820381 0.0011764912 8.666355e-01 9.341083e-01 5 123346605 123346753 149 - 1.561 1.555 -0.021
ENSG00000168944 E009 0.1308682 0.0326491905 9.664825e-02   5 123346754 123346809 56 - 0.000 0.223 14.594
ENSG00000168944 E010 41.4361636 0.0277890711 2.915405e-01 5.321632e-01 5 123349944 123350089 146 - 1.547 1.454 -0.316
ENSG00000168944 E011 5.7294784 0.1390249048 2.151606e-01 4.477393e-01 5 123350090 123352576 2487 - 0.662 0.962 1.186
ENSG00000168944 E012 0.1426347 0.0317585828 1.000000e+00   5 123358244 123358251 8 - 0.063 0.000 -12.229
ENSG00000168944 E013 0.3206185 0.0274424043 1.000000e+00   5 123358252 123358445 194 - 0.117 0.000 -13.188
ENSG00000168944 E014 1.0775605 0.0148038170 1.535507e-01   5 123358446 123358806 361 - 0.210 0.478 1.695
ENSG00000168944 E015 32.0286297 0.0024420816 6.513086e-01 8.044041e-01 5 123364496 123364594 99 - 1.430 1.400 -0.104
ENSG00000168944 E016 0.1308682 0.0326491905 9.664825e-02   5 123364595 123364795 201 - 0.000 0.223 14.594
ENSG00000168944 E017 30.8090268 0.0021780129 7.515441e-01 8.677133e-01 5 123372650 123372751 102 - 1.409 1.389 -0.072
ENSG00000168944 E018 14.9634469 0.0106348261 6.285657e-01 7.896386e-01 5 123372752 123372772 21 - 1.122 1.069 -0.191
ENSG00000168944 E019 34.6560529 0.0036768557 5.091253e-01 7.072547e-01 5 123377374 123377535 162 - 1.447 1.502 0.189
ENSG00000168944 E020 25.8302875 0.0090998523 9.120939e-01 9.581817e-01 5 123378336 123378428 93 - 1.330 1.323 -0.024
ENSG00000168944 E021 0.4820342 0.0212958601 6.696672e-01   5 123381756 123382110 355 - 0.166 0.000 -13.738
ENSG00000168944 E022 29.0722871 0.0130498762 5.909629e-01 7.643496e-01 5 123382111 123382200 90 - 1.387 1.337 -0.174
ENSG00000168944 E023 43.5215690 0.0260334357 4.263619e-01 6.482845e-01 5 123382737 123382889 153 - 1.528 1.600 0.247
ENSG00000168944 E024 36.0529227 0.0330831998 3.634960e-01 5.985969e-01 5 123382986 123383082 97 - 1.442 1.541 0.340
ENSG00000168944 E025 0.1426347 0.0317585828 1.000000e+00   5 123383083 123383399 317 - 0.063 0.000 -12.229
ENSG00000168944 E026 47.1382499 0.0064941796 1.171694e-01 3.111066e-01 5 123384951 123385133 183 - 1.601 1.485 -0.396
ENSG00000168944 E027 0.3393995 0.0274424043 1.000000e+00   5 123385802 123386517 716 - 0.117 0.000 -13.188
ENSG00000168944 E028 34.6390398 0.0080613736 4.085178e-01 6.348786e-01 5 123386518 123386667 150 - 1.466 1.399 -0.230
ENSG00000168944 E029 0.6953672 0.1809565718 5.141335e-01   5 123388304 123388431 128 - 0.213 0.000 -13.839
ENSG00000168944 E030 37.9385136 0.0018312247 8.108906e-01 9.027796e-01 5 123388432 123388606 175 - 1.490 1.512 0.074
ENSG00000168944 E031 32.4957320 0.0010835118 7.857230e-01 8.879450e-01 5 123389924 123390005 82 - 1.420 1.444 0.085
ENSG00000168944 E032 34.1797121 0.0013682273 2.595828e-01 4.985553e-01 5 123390006 123390140 135 - 1.459 1.377 -0.285
ENSG00000168944 E033 0.2922838 0.0256488465 2.893060e-01   5 123390141 123390365 225 - 0.063 0.223 2.110
ENSG00000168944 E034 2.2908586 0.0173228772 3.953576e-01 6.246209e-01 5 123390366 123391109 744 - 0.407 0.566 0.789
ENSG00000168944 E035 41.5139824 0.0008670236 1.981138e-02 9.525006e-02 5 123391110 123391337 228 - 1.553 1.389 -0.566
ENSG00000168944 E036 34.3120758 0.0086474729 6.210251e-02 2.075104e-01 5 123393300 123393497 198 - 1.473 1.309 -0.567
ENSG00000168944 E037 27.8253511 0.0016450215 1.874457e-02 9.153829e-02 5 123399136 123399284 149 - 1.388 1.179 -0.735
ENSG00000168944 E038 3.7477615 0.1168507494 1.385824e-02 7.378968e-02 5 123399285 123400649 1365 - 0.435 0.934 2.141
ENSG00000168944 E039 0.1723744 0.0329737017 9.585609e-02   5 123403217 123403255 39 - 0.000 0.223 14.595
ENSG00000168944 E040 0.4880035 0.1843071952 5.247014e-01   5 123403256 123403344 89 - 0.116 0.225 1.149
ENSG00000168944 E041 1.1356349 0.0153603286 1.524259e-01   5 123403694 123403740 47 - 0.210 0.479 1.696
ENSG00000168944 E042 0.1426347 0.0317585828 1.000000e+00   5 123409832 123409948 117 - 0.063 0.000 -12.229
ENSG00000168944 E043 33.0699456 0.0013670320 6.773555e-02 2.200068e-01 5 123412399 123412540 142 - 1.454 1.311 -0.497
ENSG00000168944 E044 26.1788184 0.0016267446 2.519323e-01 4.899892e-01 5 123416010 123416124 115 - 1.347 1.250 -0.341
ENSG00000168944 E045 24.6673007 0.0050549982 5.721150e-01 7.517928e-01 5 123418359 123418515 157 - 1.316 1.266 -0.174
ENSG00000168944 E046 0.6058878 0.1331003942 5.034250e-01   5 123422467 123422575 109 - 0.208 0.000 -13.896
ENSG00000168944 E047 0.4279040 0.6637454772 1.000000e+00   5 123422576 123422949 374 - 0.160 0.000 -12.870
ENSG00000168944 E048 12.5874440 0.0049794384 9.925177e-01 9.979386e-01 5 123422950 123423030 81 - 1.039 1.044 0.018
ENSG00000168944 E049 16.8041065 0.0025693340 3.540931e-01 5.909079e-01 5 123423031 123423421 391 - 1.166 1.070 -0.346
ENSG00000168944 E050 0.6482515 0.0241672909 7.614365e-01   5 123423509 123423592 84 - 0.166 0.223 0.522