ENSG00000168883

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323701 ENSG00000168883 HEK293_OSMI2_6hA HEK293_TMG_6hB USP39 protein_coding protein_coding 90.7511 74.87122 92.22715 7.980181 4.284274 0.3007441 52.348812 47.262536 44.843940 5.075427 2.5097696 -0.07576754 0.5736667 0.63163333 0.48780000 -0.143833333 0.08441416 0.0249366 FALSE TRUE
ENST00000409470 ENSG00000168883 HEK293_OSMI2_6hA HEK293_TMG_6hB USP39 protein_coding protein_coding 90.7511 74.87122 92.22715 7.980181 4.284274 0.3007441 15.074634 10.510720 21.205057 2.136419 0.3730279 1.01185508 0.1670958 0.13800000 0.23060000 0.092600000 0.02493660 0.0249366 FALSE TRUE
MSTRG.18776.5 ENSG00000168883 HEK293_OSMI2_6hA HEK293_TMG_6hB USP39 protein_coding   90.7511 74.87122 92.22715 7.980181 4.284274 0.3007441 5.325661 3.833652 5.403364 1.019630 1.0024079 0.49404760 0.0584750 0.04956667 0.05883333 0.009266667 0.91770322 0.0249366 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168883 E001 0.3040503 0.0274424043 1.980663e-01   2 85602856 85602857 2 + 0.217 0.000 -10.164
ENSG00000168883 E002 0.9003845 0.0403227040 9.985535e-02   2 85602858 85602858 1 + 0.418 0.120 -2.343
ENSG00000168883 E003 2.0933425 0.1552419888 6.051063e-01 7.735985e-01 2 85602859 85602873 15 + 0.555 0.417 -0.685
ENSG00000168883 E004 15.5227404 0.1189784808 3.346650e-01 5.732621e-01 2 85602874 85603081 208 + 1.137 1.282 0.512
ENSG00000168883 E005 0.1614157 0.0327231192 4.825774e-01   2 85611378 85611580 203 + 0.122 0.000 -9.166
ENSG00000168883 E006 0.0000000       2 85612103 85612104 2 +      
ENSG00000168883 E007 1.5217021 0.0665082783 3.696041e-01 6.037280e-01 2 85612105 85612121 17 + 0.296 0.468 0.987
ENSG00000168883 E008 7.7951789 0.1213594312 6.056470e-01 7.739531e-01 2 85612122 85612359 238 + 0.853 1.011 0.595
ENSG00000168883 E009 4.2809464 0.0067719863 1.752676e-01 3.975275e-01 2 85616143 85616149 7 + 0.594 0.788 0.814
ENSG00000168883 E010 5.9059899 0.0048165580 1.416355e-01 3.499326e-01 2 85616150 85616151 2 + 0.718 0.907 0.742
ENSG00000168883 E011 13.0780349 0.0024975176 4.303610e-03 3.085586e-02 2 85616152 85616168 17 + 0.975 1.248 0.983
ENSG00000168883 E012 45.2686652 0.0007833099 8.136110e-01 9.044247e-01 2 85616169 85616185 17 + 1.652 1.662 0.034
ENSG00000168883 E013 45.4112999 0.0007758512 8.592509e-01 9.299634e-01 2 85616186 85616186 1 + 1.655 1.662 0.024
ENSG00000168883 E014 66.3310822 0.0006095344 8.639548e-01 9.325820e-01 2 85616187 85616193 7 + 1.821 1.826 0.017
ENSG00000168883 E015 205.1864223 0.0082804210 1.375402e-02 7.337048e-02 2 85616194 85616289 96 + 2.244 2.370 0.420
ENSG00000168883 E016 354.1315132 0.0034106291 6.641531e-02 2.169969e-01 2 85616290 85616456 167 + 2.515 2.579 0.211
ENSG00000168883 E017 151.6266297 0.0003398766 3.996471e-01 6.279781e-01 2 85616457 85616463 7 + 2.168 2.190 0.075
ENSG00000168883 E018 333.0126859 0.0037802333 4.167324e-01 6.412045e-01 2 85619220 85619289 70 + 2.507 2.537 0.100
ENSG00000168883 E019 2.7399218 0.5291250586 5.424809e-01 7.308666e-01 2 85621207 85621326 120 + 0.484 0.643 0.728
ENSG00000168883 E020 475.1723731 0.0012103500 2.114024e-02 9.979705e-02 2 85621485 85621579 95 + 2.702 2.649 -0.174
ENSG00000168883 E021 10.7387131 0.0033749684 4.081121e-02 1.568311e-01 2 85623626 85623645 20 + 1.166 0.955 -0.769
ENSG00000168883 E022 696.8988607 0.0002744042 3.882375e-08 1.591015e-06 2 85623646 85623782 137 + 2.880 2.797 -0.278
ENSG00000168883 E023 0.0000000       2 85623783 85623790 8 +      
ENSG00000168883 E024 690.0482445 0.0001944757 2.525292e-02 1.129689e-01 2 85625539 85625691 153 + 2.852 2.818 -0.113
ENSG00000168883 E025 0.4646582 0.0217681645 5.718646e-01   2 85629109 85629157 49 + 0.122 0.215 0.979
ENSG00000168883 E026 755.9193282 0.0009326510 5.957606e-01 7.675833e-01 2 85630721 85630946 226 + 2.878 2.871 -0.022
ENSG00000168883 E027 392.2558632 0.0016166447 1.666761e-01 3.861267e-01 2 85636053 85636085 33 + 2.605 2.573 -0.109
ENSG00000168883 E028 392.0226334 0.0012652441 1.070420e-01 2.940403e-01 2 85636086 85636130 45 + 2.608 2.570 -0.125
ENSG00000168883 E029 448.6563906 0.0008275632 9.826454e-02 2.787302e-01 2 85637369 85637436 68 + 2.664 2.630 -0.113
ENSG00000168883 E030 547.7245646 0.0001363945 1.828885e-02 8.998601e-02 2 85639203 85639292 90 + 2.752 2.713 -0.129
ENSG00000168883 E031 540.5460316 0.0007680852 5.338080e-01 7.247916e-01 2 85639293 85639391 99 + 2.734 2.723 -0.035
ENSG00000168883 E032 1.7042545 0.0476427111 3.941545e-01 6.236630e-01 2 85639475 85639822 348 + 0.515 0.357 -0.835
ENSG00000168883 E033 426.7320955 0.0036527474 7.378812e-01 8.592120e-01 2 85640976 85641054 79 + 2.628 2.627 -0.003
ENSG00000168883 E034 443.3495565 0.0025177256 4.628577e-01 6.750534e-01 2 85641055 85641118 64 + 2.651 2.636 -0.049
ENSG00000168883 E035 785.6818223 0.0001014875 3.699419e-01 6.039147e-01 2 85644948 85645083 136 + 2.896 2.882 -0.045
ENSG00000168883 E036 21.3602865 0.0322370965 1.022619e-01 2.858389e-01 2 85645084 85645274 191 + 1.431 1.255 -0.611
ENSG00000168883 E037 29.7546827 0.0200177143 9.862732e-01 9.949678e-01 2 85645814 85645899 86 + 1.480 1.489 0.031
ENSG00000168883 E038 20.1758980 0.0459442550 9.326486e-01 9.684681e-01 2 85645900 85646167 268 + 1.310 1.328 0.062
ENSG00000168883 E039 718.6511508 0.0004643590 7.980233e-01 8.951953e-01 2 85647930 85648016 87 + 2.851 2.855 0.013
ENSG00000168883 E040 609.7701731 0.0004621399 1.133402e-02 6.373434e-02 2 85648761 85648853 93 + 2.759 2.802 0.142
ENSG00000168883 E041 466.6618550 0.0002014250 9.252131e-16 1.560302e-13 2 85648854 85649016 163 + 2.589 2.727 0.458
ENSG00000168883 E042 490.8571285 0.0001399952 4.152271e-09 2.121393e-07 2 85649017 85649283 267 + 2.636 2.730 0.315
ENSG00000168883 E043 0.9379465 0.8246419034 5.533098e-01   2 85657486 85657539 54 + 0.422 0.116 -2.420