ENSG00000168818

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306200 ENSG00000168818 HEK293_OSMI2_6hA HEK293_TMG_6hB STX18 protein_coding protein_coding 20.29075 17.30691 22.37131 1.526962 2.198609 0.3701125 11.911509 8.769487 13.027329 1.2507640 0.4607523 0.5704398 0.5876917 0.5197333 0.59066667 0.07093333 0.9030690629 0.0007842918 FALSE TRUE
ENST00000512195 ENSG00000168818 HEK293_OSMI2_6hA HEK293_TMG_6hB STX18 protein_coding processed_transcript 20.29075 17.30691 22.37131 1.526962 2.198609 0.3701125 3.504893 2.045476 5.146642 1.0228378 1.7131128 1.3269590 0.1603333 0.1123667 0.21933333 0.10696667 0.8030882762 0.0007842918 FALSE FALSE
ENST00000515687 ENSG00000168818 HEK293_OSMI2_6hA HEK293_TMG_6hB STX18 protein_coding retained_intron 20.29075 17.30691 22.37131 1.526962 2.198609 0.3701125 2.380368 3.628210 1.648927 0.7137366 0.2694474 -1.1329783 0.1268208 0.2059667 0.07283333 -0.13313333 0.0007842918 0.0007842918   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168818 E001 1.6886099 0.0382640138 7.019144e-01 0.8367917342 4 4415742 4416163 422 - 0.405 0.479 0.386
ENSG00000168818 E002 19.6526996 0.2377389259 2.895367e-02 0.1242231079 4 4418968 4419333 366 - 1.024 1.498 1.671
ENSG00000168818 E003 248.3722259 0.0002467971 3.468533e-04 0.0042074044 4 4419334 4419942 609 - 2.352 2.441 0.295
ENSG00000168818 E004 147.1089460 0.0003909005 7.756706e-02 0.2399830853 4 4419943 4420094 152 - 2.138 2.200 0.208
ENSG00000168818 E005 80.1882608 0.0005713923 5.812108e-01 0.7579359613 4 4420095 4420129 35 - 1.892 1.925 0.110
ENSG00000168818 E006 5.5915190 0.0648989062 1.709603e-03 0.0150820698 4 4420130 4420220 91 - 0.455 1.021 2.359
ENSG00000168818 E007 12.1411778 0.0709797950 9.178925e-02 0.2670033917 4 4420221 4420863 643 - 0.954 1.249 1.066
ENSG00000168818 E008 124.4643558 0.0102525656 8.143996e-01 0.9048867238 4 4420864 4420944 81 - 2.097 2.098 0.000
ENSG00000168818 E009 130.5611745 0.0020772562 2.207766e-01 0.4543719145 4 4423518 4423587 70 - 2.133 2.100 -0.110
ENSG00000168818 E010 15.3475960 0.0652669610 5.935923e-03 0.0394311065 4 4423588 4423823 236 - 0.940 1.381 1.580
ENSG00000168818 E011 6.9959843 0.0045203569 3.273841e-02 0.1353194407 4 4425161 4425163 3 - 0.751 1.018 1.024
ENSG00000168818 E012 83.6347124 0.0004494469 1.111951e-01 0.3009512316 4 4425164 4425172 9 - 1.952 1.902 -0.168
ENSG00000168818 E013 122.1486009 0.0003275105 6.197118e-01 0.7836460534 4 4425173 4425222 50 - 2.094 2.089 -0.015
ENSG00000168818 E014 45.5472869 0.0412164390 2.403542e-03 0.0197082067 4 4425223 4426613 1391 - 1.459 1.811 1.200
ENSG00000168818 E015 135.1517887 0.0004533521 2.735059e-01 0.5133579269 4 4434770 4434858 89 - 2.146 2.123 -0.074
ENSG00000168818 E016 96.7813798 0.0007393346 3.370988e-02 0.1380891136 4 4438394 4438438 45 - 2.024 1.958 -0.223
ENSG00000168818 E017 116.5425150 0.0005304423 7.251279e-02 0.2298008613 4 4438439 4438509 71 - 2.093 2.044 -0.161
ENSG00000168818 E018 92.8481370 0.0005470799 5.456707e-01 0.7332062324 4 4457191 4457257 67 - 1.979 1.968 -0.038
ENSG00000168818 E019 1.9049636 0.0098432258 2.954714e-01 0.5359620619 4 4457258 4457422 165 - 0.541 0.370 -0.878
ENSG00000168818 E020 95.9383239 0.0004054021 1.416986e-02 0.0750208315 4 4457423 4457500 78 - 2.023 1.947 -0.257
ENSG00000168818 E021 102.9451828 0.0004325337 1.980053e-05 0.0003790109 4 4459372 4459487 116 - 2.080 1.943 -0.460
ENSG00000168818 E022 0.0000000       4 4461902 4461905 4 -      
ENSG00000168818 E023 0.0000000       4 4461906 4461954 49 -      
ENSG00000168818 E024 70.3932860 0.0054707644 5.350149e-02 0.1878863589 4 4471639 4471706 68 - 1.899 1.811 -0.298
ENSG00000168818 E025 73.0078606 0.0093678649 7.156853e-01 0.8453612621 4 4541797 4542048 252 - 1.876 1.869 -0.020
ENSG00000168818 E026 0.3228314 0.3721641623 3.143224e-01   4 4542160 4542346 187 - 0.210 0.000 -10.286