ENSG00000168758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000474420 ENSG00000168758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA4C protein_coding retained_intron 11.74942 15.63974 9.148655 0.9636046 0.2299295 -0.772931 0.8321401 1.014915 0.4967262 0.35488679 0.25052116 -1.0162257 0.07042083 0.06703333 0.0541000 -0.01293333 0.92242031 0.02975092 FALSE TRUE
ENST00000482925 ENSG00000168758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA4C protein_coding retained_intron 11.74942 15.63974 9.148655 0.9636046 0.2299295 -0.772931 1.2206434 1.711620 1.0893927 0.41053397 0.32140706 -0.6470600 0.10237083 0.11156667 0.1174667 0.00590000 0.99609369 0.02975092 FALSE TRUE
MSTRG.18895.3 ENSG00000168758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA4C protein_coding   11.74942 15.63974 9.148655 0.9636046 0.2299295 -0.772931 2.8792134 3.041551 1.9563175 0.62748983 0.39230162 -0.6340463 0.24769167 0.19303333 0.2128667 0.01983333 0.95985365 0.02975092 FALSE TRUE
MSTRG.18895.5 ENSG00000168758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA4C protein_coding   11.74942 15.63974 9.148655 0.9636046 0.2299295 -0.772931 2.2510115 4.561132 1.3634537 0.72078359 0.05985637 -1.7347432 0.18400417 0.28836667 0.1495000 -0.13886667 0.02975092 0.02975092 FALSE TRUE
MSTRG.18895.7 ENSG00000168758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA4C protein_coding   11.74942 15.63974 9.148655 0.9636046 0.2299295 -0.772931 3.4001543 4.067343 2.8509189 0.01407888 0.50749299 -0.5111506 0.29357083 0.26183333 0.3139333 0.05210000 0.87605228 0.02975092 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168758 E001 0.0000000       2 96859718 96859735 18 -      
ENSG00000168758 E002 0.9402750 0.0295217585 4.977182e-01   2 96859736 96859741 6 - 0.161 0.334 1.363
ENSG00000168758 E003 0.9402750 0.0295217585 4.977182e-01   2 96859742 96859747 6 - 0.161 0.334 1.363
ENSG00000168758 E004 119.8490703 0.0463817500 9.718261e-02 2.768172e-01 2 96859748 96860308 561 - 1.884 2.127 0.814
ENSG00000168758 E005 275.7544269 1.2767882405 4.592326e-01 6.726257e-01 2 96860309 96861045 737 - 2.234 2.486 0.841
ENSG00000168758 E006 160.8182354 0.9495403628 2.787882e-01 5.188664e-01 2 96861046 96861455 410 - 1.895 2.279 1.288
ENSG00000168758 E007 9.3890864 0.1584916030 5.130601e-01 7.102905e-01 2 96861456 96861578 123 - 0.826 1.062 0.887
ENSG00000168758 E008 78.4591604 0.4954415490 2.311539e-01 4.664803e-01 2 96861579 96861649 71 - 1.633 1.960 1.105
ENSG00000168758 E009 94.6951936 0.5516255971 2.270128e-01 4.617890e-01 2 96861737 96861894 158 - 1.707 2.043 1.132
ENSG00000168758 E010 29.7132798 0.4404591402 7.419981e-01 8.616544e-01 2 96861895 96863328 1434 - 1.395 1.495 0.341
ENSG00000168758 E011 69.3830033 0.5182809197 3.415862e-01 5.794318e-01 2 96863682 96863794 113 - 1.653 1.889 0.795
ENSG00000168758 E012 127.9441734 0.0059210551 2.624120e-01 5.015993e-01 2 96863926 96864148 223 - 2.054 2.103 0.164
ENSG00000168758 E013 96.3787713 0.0310302656 4.048287e-01 6.321710e-01 2 96864238 96864382 145 - 1.941 1.974 0.109
ENSG00000168758 E014 110.4389303 0.0146493814 5.800867e-01 7.572201e-01 2 96864705 96864880 176 - 1.974 2.045 0.236
ENSG00000168758 E015 127.6922365 0.0035240284 3.297096e-03 2.517638e-02 2 96864964 96865115 152 - 2.100 2.079 -0.070
ENSG00000168758 E016 80.3102432 0.0006356328 6.902698e-08 2.664175e-06 2 96865204 96865233 30 - 1.967 1.845 -0.410
ENSG00000168758 E017 106.6264228 0.0137718696 2.407182e-03 1.973043e-02 2 96865234 96865320 87 - 2.065 1.977 -0.295
ENSG00000168758 E018 93.6021349 0.0261755218 5.823520e-02 1.987875e-01 2 96865441 96865537 97 - 1.987 1.932 -0.185
ENSG00000168758 E019 42.3683864 0.0236678605 2.647749e-02 1.166979e-01 2 96865666 96865666 1 - 1.675 1.578 -0.330
ENSG00000168758 E020 93.5533015 0.0249685845 5.782540e-02 1.979416e-01 2 96865667 96865764 98 - 1.985 1.934 -0.173
ENSG00000168758 E021 76.6902397 0.0011277560 1.007549e-03 9.971153e-03 2 96865867 96865929 63 - 1.898 1.852 -0.155
ENSG00000168758 E022 88.5412054 0.0048903437 4.633782e-02 1.708918e-01 2 96866283 96866431 149 - 1.929 1.927 -0.006
ENSG00000168758 E023 15.6976959 0.0669408378 6.780162e-01 8.214390e-01 2 96866432 96866930 499 - 1.170 1.215 0.161
ENSG00000168758 E024 63.8850421 0.0199308605 6.244246e-01 7.869686e-01 2 96867778 96867923 146 - 1.742 1.808 0.225
ENSG00000168758 E025 12.9351602 0.0174665799 6.167653e-01 7.815555e-01 2 96867924 96867926 3 - 1.089 1.125 0.132
ENSG00000168758 E026 12.3496233 0.0608123946 6.937696e-01 8.315310e-01 2 96868416 96868588 173 - 0.981 1.162 0.657
ENSG00000168758 E027 24.2141441 0.0077713657 4.411582e-02 1.653945e-01 2 96869187 96869469 283 - 1.174 1.452 0.972
ENSG00000168758 E028 9.5411192 0.0039298967 9.566676e-02 2.741919e-01 2 96869876 96870310 435 - 1.055 0.960 -0.350
ENSG00000168758 E029 0.7119354 1.3574822426 2.353730e-01   2 96870378 96870757 380 - 0.468 0.000 -11.219