ENSG00000168710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369799 ENSG00000168710 HEK293_OSMI2_6hA HEK293_TMG_6hB AHCYL1 protein_coding protein_coding 43.49672 29.57421 47.34648 5.882956 1.204379 0.6787348 20.114460 13.4354491 24.64228841 1.63051795 1.91968718 0.8746036 0.45254167 0.47003333 0.519133333 0.04910000 0.86596441 0.02114091 FALSE TRUE
ENST00000475081 ENSG00000168710 HEK293_OSMI2_6hA HEK293_TMG_6hB AHCYL1 protein_coding processed_transcript 43.49672 29.57421 47.34648 5.882956 1.204379 0.6787348 2.934727 0.4286809 3.56206961 0.07841814 0.59453794 3.0255165 0.05840833 0.01660000 0.075966667 0.05936667 0.02114091 0.02114091 TRUE TRUE
ENST00000481423 ENSG00000168710 HEK293_OSMI2_6hA HEK293_TMG_6hB AHCYL1 protein_coding processed_transcript 43.49672 29.57421 47.34648 5.882956 1.204379 0.6787348 6.361553 5.6084339 0.05010045 4.34060078 0.05010045 -6.5466483 0.15892500 0.14850000 0.001033333 -0.14746667 0.40462858 0.02114091   FALSE
MSTRG.1771.3 ENSG00000168710 HEK293_OSMI2_6hA HEK293_TMG_6hB AHCYL1 protein_coding   43.49672 29.57421 47.34648 5.882956 1.204379 0.6787348 2.749333 1.4247021 3.50179343 0.18540830 0.62415922 1.2914568 0.06189167 0.05033333 0.073466667 0.02313333 0.63512085 0.02114091 TRUE TRUE
MSTRG.1771.4 ENSG00000168710 HEK293_OSMI2_6hA HEK293_TMG_6hB AHCYL1 protein_coding   43.49672 29.57421 47.34648 5.882956 1.204379 0.6787348 5.047300 2.9141120 8.19317040 0.16613397 0.55819729 1.4881830 0.11731250 0.10833333 0.173433333 0.06510000 0.48497602 0.02114091 TRUE TRUE
MSTRG.1771.7 ENSG00000168710 HEK293_OSMI2_6hA HEK293_TMG_6hB AHCYL1 protein_coding   43.49672 29.57421 47.34648 5.882956 1.204379 0.6787348 5.645269 5.2824085 6.22480310 0.48359363 1.02754620 0.2364196 0.13577500 0.18660000 0.132133333 -0.05446667 0.63701109 0.02114091 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168710 E001 44.3536099 0.0077071836 7.786818e-02 0.240564817 1 109984765 109985002 238 + 1.574 1.743 0.573
ENSG00000168710 E002 5.0678000 0.0064092773 4.366617e-01 0.656221323 1 109985003 109985005 3 + 0.717 0.863 0.580
ENSG00000168710 E003 5.8494924 0.0052309546 1.711742e-01 0.392071003 1 109985006 109985014 9 + 0.737 0.953 0.839
ENSG00000168710 E004 156.8415848 0.0002880403 2.877384e-01 0.528465964 1 109985015 109985172 158 + 2.175 2.194 0.065
ENSG00000168710 E005 0.8206259 0.0194637794 9.968156e-01   1 109985173 109985543 371 + 0.242 0.265 0.174
ENSG00000168710 E006 0.0000000       1 110004131 110004451 321 +      
ENSG00000168710 E007 228.9960889 0.0009495479 2.232035e-02 0.103653611 1 110009034 110009145 112 + 2.351 2.339 -0.041
ENSG00000168710 E008 277.0426741 0.0007523743 2.018264e-03 0.017182987 1 110011214 110011357 144 + 2.439 2.414 -0.085
ENSG00000168710 E009 131.4079503 0.0003096374 9.116994e-05 0.001383500 1 110012362 110012386 25 + 2.134 2.057 -0.257
ENSG00000168710 E010 211.9647049 0.0002829217 1.234185e-04 0.001779983 1 110012387 110012462 76 + 2.332 2.284 -0.160
ENSG00000168710 E011 234.6636810 0.0016109201 1.935679e-02 0.093707395 1 110012897 110012999 103 + 2.365 2.346 -0.064
ENSG00000168710 E012 225.0704835 0.0021268526 1.654903e-02 0.083807657 1 110014763 110014857 95 + 2.350 2.324 -0.089
ENSG00000168710 E013 227.6332340 0.0002267923 7.408620e-02 0.232913858 1 110015425 110015531 107 + 2.341 2.348 0.024
ENSG00000168710 E014 192.4424978 0.0003259969 4.930785e-04 0.005610833 1 110016344 110016460 117 + 2.289 2.245 -0.146
ENSG00000168710 E015 188.9648099 0.0003053416 1.343150e-03 0.012486191 1 110016667 110016730 64 + 2.278 2.242 -0.122
ENSG00000168710 E016 193.0107623 0.0013267284 5.086495e-02 0.181738382 1 110017495 110017583 89 + 2.279 2.270 -0.030
ENSG00000168710 E017 199.1590815 0.0039329620 1.214062e-02 0.067016304 1 110017946 110018016 71 + 2.306 2.259 -0.159
ENSG00000168710 E018 202.5123809 0.0010436694 6.491206e-03 0.042153496 1 110018373 110018431 59 + 2.306 2.277 -0.098
ENSG00000168710 E019 182.8516050 0.0054999413 7.075039e-02 0.226229307 1 110018432 110018467 36 + 2.262 2.233 -0.099
ENSG00000168710 E020 236.4057877 0.0028999807 4.851492e-02 0.176226660 1 110018552 110018650 99 + 2.368 2.351 -0.058
ENSG00000168710 E021 9.5605381 0.0119950283 2.789835e-01 0.519058779 1 110018651 110018874 224 + 1.038 0.954 -0.308
ENSG00000168710 E022 21.5052112 0.0287859503 2.530635e-01 0.491317093 1 110018875 110019050 176 + 1.362 1.287 -0.263
ENSG00000168710 E023 227.7896617 0.0009870925 5.134928e-01 0.710587248 1 110019051 110019119 69 + 2.314 2.383 0.231
ENSG00000168710 E024 236.0400564 0.0002621039 1.408056e-01 0.348765724 1 110019548 110019626 79 + 2.323 2.409 0.286
ENSG00000168710 E025 227.8704741 0.0057661726 6.779218e-01 0.821418357 1 110020731 110020851 121 + 2.329 2.368 0.131
ENSG00000168710 E026 1869.3540618 0.0094576252 5.563471e-04 0.006188951 1 110021674 110023742 2069 + 3.182 3.360 0.593