ENSG00000168610

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264657 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 6.7724660 9.880026 5.9601409 1.3020353 0.2992999 -0.7282094 0.40129583 0.46010000 0.37696667 -0.08313333 6.788373e-01 2.573991e-24 FALSE TRUE
ENST00000588969 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 1.5128114 0.000000 3.0491843 0.0000000 0.2833242 8.2570032 0.09400417 0.00000000 0.19153333 0.19153333 2.573991e-24 2.573991e-24 FALSE TRUE
ENST00000677030 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 0.4427432 0.000000 0.9457291 0.0000000 0.5073075 6.5785298 0.02799583 0.00000000 0.05873333 0.05873333 2.642297e-01 2.573991e-24 FALSE TRUE
ENST00000677723 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 1.1659467 1.591668 1.5185711 1.0499507 0.8293855 -0.0673919 0.07213750 0.08080000 0.10040000 0.01960000 9.895229e-01 2.573991e-24 FALSE TRUE
ENST00000678044 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 2.7019285 3.840564 1.3140556 1.1940433 0.8275027 -1.5401060 0.16046250 0.17470000 0.07790000 -0.09680000 7.220998e-01 2.573991e-24 FALSE TRUE
ENST00000678674 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 0.7077474 1.152851 0.0000000 0.7137313 0.0000000 -6.8615222 0.03956250 0.05010000 0.00000000 -0.05010000 3.652721e-01 2.573991e-24 FALSE TRUE
ENST00000678827 ENSG00000168610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAT3 protein_coding protein_coding 16.71846 21.35956 15.97676 1.799764 0.8822264 -0.4186796 0.5566237 1.820410 0.4482547 0.6324408 0.4482547 -1.9979452 0.03143333 0.08263333 0.02990000 -0.05273333 3.781102e-01 2.573991e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168610 E001 17.0941453 0.0741739699 1.215246e-01 0.3182713310 17 42313324 42313411 88 - 1.051 1.327 0.980
ENSG00000168610 E002 16.8388441 0.1440763404 3.845861e-01 0.6161469097 17 42313412 42313420 9 - 1.120 1.296 0.622
ENSG00000168610 E003 25.6428006 0.2414564678 2.936793e-01 0.5343175933 17 42313421 42313445 25 - 1.254 1.481 0.789
ENSG00000168610 E004 49.8118984 0.4009341463 1.893687e-01 0.4161740451 17 42313446 42313470 25 - 1.458 1.784 1.110
ENSG00000168610 E005 591.5859590 1.5587009699 4.266857e-01 0.6485306184 17 42313471 42314847 1377 - 2.538 2.847 1.028
ENSG00000168610 E006 35.6250260 0.2734274201 1.307860e-01 0.3330154970 17 42314848 42314853 6 - 1.304 1.645 1.176
ENSG00000168610 E007 59.7224445 0.4440811015 1.753304e-01 0.3976114394 17 42314854 42314902 49 - 1.516 1.866 1.190
ENSG00000168610 E008 242.5039411 1.2453193649 4.076871e-01 0.6342550113 17 42314903 42315467 565 - 2.165 2.456 0.970
ENSG00000168610 E009 66.4709486 0.5692777375 3.394746e-01 0.5775266180 17 42315468 42315490 23 - 1.656 1.884 0.769
ENSG00000168610 E010 70.3308260 0.5931364279 3.530041e-01 0.5900183005 17 42315491 42315510 20 - 1.687 1.906 0.737
ENSG00000168610 E011 95.1378489 0.6904265780 3.564292e-01 0.5928837747 17 42315511 42315558 48 - 1.807 2.038 0.777
ENSG00000168610 E012 89.1025256 0.7082491056 4.387153e-01 0.6577825380 17 42315559 42315596 38 - 1.824 1.994 0.569
ENSG00000168610 E013 160.2958678 1.1857580449 5.546422e-01 0.7395369997 17 42315597 42315800 204 - 2.095 2.239 0.480
ENSG00000168610 E014 99.8157376 0.0363926040 4.699644e-01 0.6800561145 17 42316789 42316851 63 - 1.910 2.026 0.390
ENSG00000168610 E015 78.4337465 0.0025180360 2.031499e-01 0.4335254266 17 42316852 42316889 38 - 1.793 1.920 0.428
ENSG00000168610 E016 72.3823253 0.0005866280 1.803640e-01 0.4044584606 17 42316890 42316901 12 - 1.760 1.886 0.422
ENSG00000168610 E017 2.5328184 0.0677631975 4.361549e-01 0.6559201879 17 42316902 42317181 280 - 0.596 0.507 -0.415
ENSG00000168610 E018 106.7088351 0.0035470043 6.535103e-01 0.8057677867 17 42317182 42317224 43 - 1.950 2.042 0.307
ENSG00000168610 E019 2.1374669 0.1272920263 7.523880e-02 0.2353003458 17 42317225 42317326 102 - 0.152 0.583 2.753
ENSG00000168610 E020 6.2541546 0.2168373717 2.355593e-01 0.4714710884 17 42317327 42317703 377 - 0.547 0.953 1.658
ENSG00000168610 E021 2.9147490 0.2257244321 7.828352e-01 0.8863131136 17 42319856 42320073 218 - 0.550 0.583 0.149
ENSG00000168610 E022 3.2230510 0.2907582598 6.900345e-01 0.8290899556 17 42321156 42321953 798 - 0.594 0.627 0.148
ENSG00000168610 E023 2.2749400 0.1652251144 7.619801e-01 0.8737954978 17 42321954 42322281 328 - 0.492 0.487 -0.021
ENSG00000168610 E024 57.5421214 0.0135162300 6.230041e-01 0.7858548465 17 42322282 42322284 3 - 1.722 1.761 0.131
ENSG00000168610 E025 197.1323392 0.0136619689 8.538497e-01 0.9270363632 17 42322285 42322494 210 - 2.235 2.303 0.225
ENSG00000168610 E026 91.2781677 0.0088889144 2.885186e-01 0.5292577817 17 42323004 42323034 31 - 1.938 1.951 0.043
ENSG00000168610 E027 91.4284880 0.0242902690 4.248641e-01 0.6471736061 17 42323035 42323063 29 - 1.938 1.953 0.052
ENSG00000168610 E028 124.1601182 0.0081940123 3.262237e-01 0.5653956555 17 42323064 42323143 80 - 2.063 2.086 0.080
ENSG00000168610 E029 0.7679007 0.0219887788 5.072970e-01   17 42323144 42323259 116 - 0.152 0.299 1.242
ENSG00000168610 E030 87.4724474 0.0163366028 9.550135e-01 0.9794147944 17 42323260 42323286 27 - 1.881 1.953 0.245
ENSG00000168610 E031 116.0735160 0.0156123034 3.439645e-01 0.5815834249 17 42323287 42323354 68 - 2.038 2.056 0.059
ENSG00000168610 E032 3.7459788 0.3041665801 7.514391e-01 0.8676735556 17 42323355 42323452 98 - 0.704 0.638 -0.278
ENSG00000168610 E033 4.8497395 0.2403213911 9.453905e-01 0.9750193476 17 42323453 42323572 120 - 0.675 0.790 0.471
ENSG00000168610 E034 110.6201469 0.0082754953 1.943613e-02 0.0939647882 17 42323573 42323625 53 - 2.059 2.007 -0.173
ENSG00000168610 E035 165.9997631 0.0098154316 9.348205e-03 0.0552976494 17 42324711 42324825 115 - 2.241 2.180 -0.204
ENSG00000168610 E036 81.4497300 0.0052634215 2.716805e-02 0.1187989543 17 42324826 42324846 21 - 1.922 1.878 -0.146
ENSG00000168610 E037 145.3062821 0.0102686967 8.332135e-02 0.2514104305 17 42324963 42325061 99 - 2.156 2.139 -0.056
ENSG00000168610 E038 0.5885118 0.0337629539 5.175150e-01   17 42325062 42325157 96 - 0.264 0.175 -0.754
ENSG00000168610 E039 125.6018873 0.0009678264 3.197676e-05 0.0005703592 17 42326116 42326199 84 - 2.129 2.051 -0.261
ENSG00000168610 E040 0.4952057 0.1946876949 3.105550e-01   17 42326200 42326715 516 - 0.265 0.097 -1.751
ENSG00000168610 E041 0.3393995 0.0252266443 7.256556e-02   17 42328951 42329409 459 - 0.265 0.000 -12.778
ENSG00000168610 E042 111.9124484 0.0036720632 3.937993e-04 0.0046703561 17 42329410 42329457 48 - 2.083 1.998 -0.287
ENSG00000168610 E043 1.1005754 0.1559968635 4.200531e-01   17 42329458 42329553 96 - 0.153 0.358 1.601
ENSG00000168610 E044 132.3033736 0.0075817731 1.754152e-03 0.0153951051 17 42329554 42329647 94 - 2.159 2.072 -0.290
ENSG00000168610 E045 1.0011825 0.0196191278 9.787323e-01   17 42329658 42329746 89 - 0.264 0.300 0.246
ENSG00000168610 E046 77.6969872 0.0161344906 6.104390e-02 0.2051138267 17 42329747 42329776 30 - 1.918 1.854 -0.217
ENSG00000168610 E047 0.6258862 0.0207646617 7.177612e-01   17 42329777 42329791 15 - 0.152 0.242 0.828
ENSG00000168610 E048 0.6841482 0.1581838724 5.264584e-01   17 42330631 42331471 841 - 0.266 0.176 -0.753
ENSG00000168610 E049 81.4524728 0.0337309733 1.293913e-01 0.3308332800 17 42331472 42331531 60 - 1.945 1.870 -0.251
ENSG00000168610 E050 0.1723744 0.0343131834 1.000000e+00   17 42331532 42331538 7 - 0.000 0.096 10.233
ENSG00000168610 E051 91.0834710 0.0237787566 3.062904e-01 0.5469579801 17 42333673 42333765 93 - 1.951 1.944 -0.025
ENSG00000168610 E052 131.5346415 0.0080245420 1.473774e-02 0.0771019577 17 42333891 42334049 159 - 2.139 2.084 -0.184
ENSG00000168610 E053 130.3389506 0.0288129112 1.585506e-01 0.3745850249 17 42337435 42337586 152 - 2.132 2.083 -0.165
ENSG00000168610 E054 90.2754882 0.0277050009 1.202669e-01 0.3162719008 17 42337763 42337857 95 - 1.983 1.920 -0.214
ENSG00000168610 E055 88.6426152 0.0197745060 2.617074e-01 0.5007798096 17 42338731 42338812 82 - 1.944 1.932 -0.041
ENSG00000168610 E056 94.7615804 0.0078018578 2.660616e-01 0.5055370656 17 42339314 42339409 96 - 1.958 1.968 0.034
ENSG00000168610 E057 0.0000000       17 42345414 42345558 145 -      
ENSG00000168610 E058 97.7644244 0.0064740196 4.875632e-03 0.0339496572 17 42345559 42345657 99 - 2.026 1.949 -0.257
ENSG00000168610 E059 120.7847776 0.0020622851 1.252835e-04 0.0018033577 17 42346569 42346713 145 - 2.117 2.037 -0.267
ENSG00000168610 E060 117.0850971 0.0139860962 4.197210e-01 0.6434625097 17 42348389 42348517 129 - 2.040 2.063 0.077
ENSG00000168610 E061 36.6699068 0.0231651778 6.966094e-01 0.8333941360 17 42348518 42348520 3 - 1.535 1.572 0.126
ENSG00000168610 E062 31.5675360 0.0100418358 5.391374e-01 0.7283844269 17 42348521 42348539 19 - 1.483 1.503 0.068
ENSG00000168610 E063 0.1723744 0.0343131834 1.000000e+00   17 42374059 42374206 148 - 0.000 0.096 10.233
ENSG00000168610 E064 0.6376527 0.0193421984 5.105591e-01   17 42386939 42388278 1340 - 0.264 0.175 -0.754
ENSG00000168610 E065 92.7775465 0.0113237020 4.105325e-01 0.6364381973 17 42388279 42388540 262 - 1.868 1.996 0.431