ENSG00000168488

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340394 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding protein_coding 79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 12.344408 19.165900 7.777964 1.8505595 0.16071012 -1.2999761 0.15791667 0.18366667 0.10723333 -0.076433333 5.224263e-04 1.972428e-37 FALSE TRUE
ENST00000567024 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding protein_coding 79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 5.064155 4.850933 0.000000 1.5641429 0.00000000 -8.9250893 0.05697917 0.04473333 0.00000000 -0.044733333 2.032297e-14 1.972428e-37   FALSE
ENST00000568266 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding protein_coding 79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 2.854299 0.000000 5.223895 0.0000000 0.07423298 9.0317412 0.04079583 0.00000000 0.07200000 0.072000000 1.972428e-37 1.972428e-37 FALSE TRUE
MSTRG.12366.10 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding   79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 4.246826 3.070346 7.976883 1.5525062 0.80288487 1.3745401 0.05565000 0.02676667 0.10923333 0.082466667 5.836270e-01 1.972428e-37 FALSE TRUE
MSTRG.12366.16 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding   79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 1.751954 5.592933 0.000000 2.0000931 0.00000000 -9.1300386 0.02014583 0.05140000 0.00000000 -0.051400000 1.233209e-09 1.972428e-37 FALSE TRUE
MSTRG.12366.27 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding   79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 4.955364 6.586319 4.501982 0.5776792 0.32008042 -0.5479001 0.06292917 0.06370000 0.06176667 -0.001933333 9.867874e-01 1.972428e-37 TRUE TRUE
MSTRG.12366.28 ENSG00000168488 HEK293_OSMI2_6hA HEK293_TMG_6hB ATXN2L protein_coding   79.36699 104.5399 72.84661 10.73496 2.899601 -0.5210601 20.356624 30.270516 23.034645 0.8106801 1.06896005 -0.3939582 0.25639167 0.29540000 0.31643333 0.021033333 9.177750e-01 1.972428e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168488 E001 11.796838 0.0346775215 4.493253e-03 3.190254e-02 16 28822999 28823034 36 + 0.763 1.192 1.605
ENSG00000168488 E002 10.259694 0.0066362478 5.370640e-03 3.655251e-02 16 28823035 28823047 13 + 0.764 1.126 1.361
ENSG00000168488 E003 18.712423 0.0042451324 3.125700e-06 7.698559e-05 16 28823048 28823092 45 + 0.903 1.393 1.761
ENSG00000168488 E004 13.925020 0.0027662409 1.012235e-05 2.118570e-04 16 28823093 28823094 2 + 0.765 1.280 1.904
ENSG00000168488 E005 70.587206 0.5735487182 1.944116e-01 4.226208e-01 16 28823095 28823251 157 + 1.578 1.926 1.175
ENSG00000168488 E006 111.552446 0.6835161166 1.738230e-01 3.956334e-01 16 28823252 28823481 230 + 1.725 2.133 1.373
ENSG00000168488 E007 95.266732 0.6912208726 2.472641e-01 4.850037e-01 16 28823482 28823558 77 + 1.730 2.049 1.074
ENSG00000168488 E008 29.888863 0.0027164939 3.288619e-01 5.678181e-01 16 28824138 28824271 134 + 1.495 1.449 -0.157
ENSG00000168488 E009 22.071462 0.0017807849 4.323844e-01 6.530199e-01 16 28824272 28824311 40 + 1.368 1.331 -0.130
ENSG00000168488 E010 37.366246 0.0009649254 7.388328e-02 2.325385e-01 16 28824312 28824450 139 + 1.469 1.604 0.461
ENSG00000168488 E011 49.677585 0.0008899203 7.234478e-03 4.574868e-02 16 28824451 28824542 92 + 1.562 1.734 0.585
ENSG00000168488 E012 14.302606 0.0142972095 1.054902e-02 6.044896e-02 16 28824543 28824661 119 + 1.307 1.061 -0.875
ENSG00000168488 E013 114.702556 0.0322378344 4.004926e-02 1.548496e-01 16 28825366 28825370 5 + 1.901 2.103 0.678
ENSG00000168488 E014 190.338929 0.0050411689 1.555250e-01 3.701943e-01 16 28825371 28825402 32 + 2.206 2.289 0.278
ENSG00000168488 E015 281.805170 0.0002288282 1.454537e-01 3.555947e-01 16 28825624 28825680 57 + 2.439 2.429 -0.033
ENSG00000168488 E016 4.092773 0.0062923209 2.076977e-01 4.390517e-01 16 28825681 28825769 89 + 0.796 0.636 -0.662
ENSG00000168488 E017 417.903570 0.0004682213 4.917419e-08 1.965845e-06 16 28825770 28825841 72 + 2.657 2.568 -0.295
ENSG00000168488 E018 4.823367 0.1333908076 8.443756e-02 2.535889e-01 16 28825842 28826184 343 + 0.925 0.614 -1.250
ENSG00000168488 E019 766.861956 0.0004548480 1.048247e-27 7.120659e-25 16 28826240 28826390 151 + 2.958 2.804 -0.513
ENSG00000168488 E020 2.522407 0.0090111695 4.255347e-01 6.476929e-01 16 28826391 28826605 215 + 0.609 0.496 -0.521
ENSG00000168488 E021 642.694938 0.0004629288 6.935882e-24 3.149391e-21 16 28826862 28826923 62 + 2.880 2.730 -0.502
ENSG00000168488 E022 594.818311 0.0001125200 7.891420e-24 3.545356e-21 16 28826924 28826986 63 + 2.836 2.706 -0.432
ENSG00000168488 E023 590.063023 0.0001164829 2.105074e-15 3.382119e-13 16 28829401 28829492 92 + 2.814 2.715 -0.330
ENSG00000168488 E024 4.641860 0.5015641966 3.126330e-01 5.529581e-01 16 28829778 28829857 80 + 0.834 0.666 -0.678
ENSG00000168488 E025 300.835473 0.0002488739 2.796218e-07 9.269361e-06 16 28829858 28829868 11 + 2.515 2.425 -0.298
ENSG00000168488 E026 666.349252 0.0024856179 3.744003e-01 6.076919e-01 16 28829869 28830058 190 + 2.806 2.802 -0.015
ENSG00000168488 E027 591.400437 0.0116685362 3.532110e-01 5.901700e-01 16 28830615 28830790 176 + 2.707 2.773 0.219
ENSG00000168488 E028 4.610344 0.0084697516 2.378757e-02 1.084477e-01 16 28830791 28830802 12 + 0.904 0.611 -1.186
ENSG00000168488 E029 4.015005 0.0879083819 1.712990e-02 8.592677e-02 16 28830803 28830936 134 + 0.905 0.496 -1.725
ENSG00000168488 E030 344.634280 0.0010915681 8.132532e-01 9.041985e-01 16 28830962 28830984 23 + 2.501 2.531 0.098
ENSG00000168488 E031 527.976343 0.0001472386 3.256282e-01 5.648521e-01 16 28830985 28831072 88 + 2.699 2.706 0.024
ENSG00000168488 E032 25.874730 0.0112116753 1.074098e-01 2.947080e-01 16 28832187 28832204 18 + 1.481 1.365 -0.404
ENSG00000168488 E033 920.664249 0.0001290432 5.359187e-02 1.880827e-01 16 28832205 28832399 195 + 2.945 2.943 -0.006
ENSG00000168488 E034 576.379692 0.0004877098 2.039537e-03 1.732495e-02 16 28832496 28832567 72 + 2.762 2.728 -0.112
ENSG00000168488 E035 630.402436 0.0013157830 5.320135e-03 3.629652e-02 16 28832817 28832887 71 + 2.804 2.765 -0.131
ENSG00000168488 E036 864.570115 0.0037465799 1.658035e-01 3.848571e-01 16 28833059 28833195 137 + 2.928 2.908 -0.066
ENSG00000168488 E037 793.211788 0.0014677506 5.360809e-01 7.263712e-01 16 28833196 28833354 159 + 2.872 2.882 0.033
ENSG00000168488 E038 530.205683 0.0004868012 1.285498e-01 3.295700e-01 16 28833439 28833508 70 + 2.709 2.704 -0.017
ENSG00000168488 E039 22.793162 0.1858258123 3.572897e-02 1.435066e-01 16 28833856 28834064 209 + 1.553 1.198 -1.234
ENSG00000168488 E040 723.563809 0.0008957829 4.037760e-01 6.313573e-01 16 28834065 28834211 147 + 2.814 2.854 0.134
ENSG00000168488 E041 3.612571 0.0776515231 8.818429e-01 9.423349e-01 16 28834329 28834342 14 + 0.652 0.641 -0.048
ENSG00000168488 E042 492.139486 0.0021420257 1.678347e-02 8.466669e-02 16 28834343 28834415 73 + 2.610 2.702 0.306
ENSG00000168488 E043 277.948177 0.0004741313 1.455366e-08 6.585521e-07 16 28834506 28834522 17 + 2.311 2.478 0.558
ENSG00000168488 E044 664.644760 0.0045324292 5.923470e-02 2.010757e-01 16 28834523 28834693 171 + 2.741 2.832 0.300
ENSG00000168488 E045 11.307975 0.0868962089 3.778873e-02 1.490627e-01 16 28834852 28835057 206 + 1.261 0.921 -1.233
ENSG00000168488 E046 375.977064 0.0017571375 1.871914e-01 4.133004e-01 16 28835058 28835098 41 + 2.517 2.577 0.201
ENSG00000168488 E047 516.901103 0.0033327811 1.136860e-01 3.052941e-01 16 28835099 28835187 89 + 2.643 2.719 0.251
ENSG00000168488 E048 9.716742 0.2449324165 1.027123e-01 2.866306e-01 16 28835188 28835277 90 + 1.183 0.877 -1.122
ENSG00000168488 E049 623.748981 0.0011322571 4.769905e-03 3.337892e-02 16 28835278 28835399 122 + 2.718 2.804 0.285
ENSG00000168488 E050 20.287735 0.1611943638 7.756971e-02 2.399869e-01 16 28835400 28835545 146 + 1.470 1.190 -0.976
ENSG00000168488 E051 67.798645 0.0007197514 4.874472e-01 6.922483e-01 16 28835546 28835548 3 + 1.782 1.838 0.188
ENSG00000168488 E052 278.701309 0.0002600122 3.598644e-03 2.692570e-02 16 28835549 28835554 6 + 2.365 2.458 0.310
ENSG00000168488 E053 398.933815 0.0009277811 1.156888e-03 1.109979e-02 16 28835555 28835594 40 + 2.513 2.616 0.342
ENSG00000168488 E054 433.453080 0.0015895737 3.393232e-04 4.132297e-03 16 28835595 28835668 74 + 2.536 2.657 0.404
ENSG00000168488 E055 349.134307 0.0047543712 8.021571e-03 4.941587e-02 16 28835669 28835758 90 + 2.432 2.566 0.447
ENSG00000168488 E056 469.935840 0.0034756665 4.035541e-02 1.556325e-01 16 28835933 28836122 190 + 2.587 2.684 0.322
ENSG00000168488 E057 171.470127 0.0002416369 1.431014e-01 3.521394e-01 16 28836123 28836176 54 + 2.230 2.211 -0.061
ENSG00000168488 E058 236.628638 0.0128564303 8.697870e-01 9.357193e-01 16 28836177 28836325 149 + 2.332 2.366 0.113
ENSG00000168488 E059 252.561320 0.0143363648 3.896125e-01 6.201913e-01 16 28836326 28836445 120 + 2.329 2.409 0.265
ENSG00000168488 E060 133.489786 0.0283454521 8.581758e-01 9.293974e-01 16 28836446 28836448 3 + 2.099 2.112 0.042
ENSG00000168488 E061 213.848399 0.0143226092 8.953272e-01 9.493838e-01 16 28836449 28836485 37 + 2.289 2.322 0.112
ENSG00000168488 E062 107.961697 0.0145201387 5.768383e-01 7.550214e-01 16 28836486 28836490 5 + 1.974 2.036 0.208
ENSG00000168488 E063 229.097582 0.0127404934 7.376404e-01 8.590258e-01 16 28836491 28836597 107 + 2.340 2.342 0.008
ENSG00000168488 E064 318.966451 0.0111226533 3.163103e-01 5.563506e-01 16 28836598 28836727 130 + 2.505 2.473 -0.107
ENSG00000168488 E065 310.697444 0.0019566966 1.188084e-01 3.139025e-01 16 28836728 28836747 20 + 2.427 2.497 0.233
ENSG00000168488 E066 278.659146 0.0021155755 3.596783e-02 1.441387e-01 16 28836748 28836750 3 + 2.367 2.456 0.299
ENSG00000168488 E067 572.279221 0.0013033025 8.547778e-05 1.311879e-03 16 28836751 28836849 99 + 2.661 2.776 0.383
ENSG00000168488 E068 761.740085 0.0536751377 3.687812e-02 1.466206e-01 16 28836850 28837237 388 + 2.699 2.927 0.759