ENSG00000168411

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361070 ENSG00000168411 HEK293_OSMI2_6hA HEK293_TMG_6hB RFWD3 protein_coding protein_coding 40.3155 24.96728 50.81888 3.675923 2.278635 1.025032 26.504068 19.8387921 26.071866 2.6657010 4.3176157 0.3939959 0.69115833 0.79933333 0.50743333 -0.2919000 0.0136289 0.0136289 FALSE TRUE
ENST00000571750 ENSG00000168411 HEK293_OSMI2_6hA HEK293_TMG_6hB RFWD3 protein_coding protein_coding 40.3155 24.96728 50.81888 3.675923 2.278635 1.025032 5.070143 2.8439808 7.783803 0.4944017 0.6420567 1.4493518 0.11574167 0.11373333 0.15493333 0.0412000 0.6115143 0.0136289 FALSE TRUE
ENST00000575281 ENSG00000168411 HEK293_OSMI2_6hA HEK293_TMG_6hB RFWD3 protein_coding retained_intron 40.3155 24.96728 50.81888 3.675923 2.278635 1.025032 0.998689 0.3527526 3.176811 0.2445691 0.9273606 3.1350558 0.02156667 0.01386667 0.06396667 0.0501000 0.3993321 0.0136289 FALSE FALSE
MSTRG.13032.2 ENSG00000168411 HEK293_OSMI2_6hA HEK293_TMG_6hB RFWD3 protein_coding   40.3155 24.96728 50.81888 3.675923 2.278635 1.025032 4.968914 0.7268936 10.127267 0.5994685 0.2671671 3.7820688 0.10317083 0.02503333 0.19970000 0.1746667 0.1075120 0.0136289 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168411 E001 257.8497323 1.369010907 0.3209277926 0.560518759 16 74621399 74621831 433 - 2.217 2.592 1.252
ENSG00000168411 E002 797.5118534 1.797408713 0.4542837931 0.668948612 16 74621832 74622872 1041 - 2.763 3.038 0.915
ENSG00000168411 E003 639.2249483 1.745345023 0.5073643413 0.705922974 16 74622873 74623428 556 - 2.697 2.916 0.728
ENSG00000168411 E004 243.8054703 1.417624621 0.4694367827 0.679652188 16 74623429 74623538 110 - 2.275 2.502 0.757
ENSG00000168411 E005 165.1645178 1.288240970 0.4738273894 0.682685621 16 74623539 74623597 59 - 2.119 2.322 0.680
ENSG00000168411 E006 469.2334584 1.650668280 0.5197008792 0.714812321 16 74623598 74624071 474 - 2.574 2.771 0.655
ENSG00000168411 E007 297.7756639 0.000171781 0.0695696755 0.223905972 16 74626343 74626554 212 - 2.427 2.512 0.284
ENSG00000168411 E008 155.0664153 0.014766128 0.5980178536 0.768944038 16 74628452 74628507 56 - 2.166 2.202 0.119
ENSG00000168411 E009 235.9866702 0.019782253 0.6645642834 0.812752225 16 74628508 74628666 159 - 2.343 2.391 0.161
ENSG00000168411 E010 269.4458653 0.020012688 0.2134957234 0.445803488 16 74630781 74630957 177 - 2.423 2.415 -0.026
ENSG00000168411 E011 263.9284200 0.024635129 0.1206603705 0.316917056 16 74632523 74632673 151 - 2.424 2.389 -0.115
ENSG00000168411 E012 0.7721051 0.106667481 0.3566161163   16 74632674 74632733 60 - 0.304 0.149 -1.309
ENSG00000168411 E013 325.3273088 0.015973428 0.1602282281 0.377145940 16 74636346 74636577 232 - 2.505 2.497 -0.027
ENSG00000168411 E014 128.5314348 0.013486355 0.0401835433 0.155168235 16 74637856 74637875 20 - 2.122 2.062 -0.201
ENSG00000168411 E015 193.5627897 0.018589142 0.0495290226 0.178482519 16 74637876 74637970 95 - 2.300 2.238 -0.208
ENSG00000168411 E016 1.9560731 0.180150153 0.6634568102 0.812066917 16 74643979 74644361 383 - 0.405 0.537 0.664
ENSG00000168411 E017 216.3221639 0.029590372 0.0504548742 0.180730260 16 74644362 74644453 92 - 2.359 2.266 -0.309
ENSG00000168411 E018 187.4985323 0.031247317 0.0912784320 0.266034057 16 74644541 74644619 79 - 2.290 2.216 -0.247
ENSG00000168411 E019 254.6867292 0.031611062 0.0716139654 0.228067481 16 74644620 74644735 116 - 2.422 2.349 -0.245
ENSG00000168411 E020 195.0214981 0.026805198 0.0688884000 0.222550140 16 74649132 74649193 62 - 2.301 2.242 -0.199
ENSG00000168411 E021 123.7743486 0.024270160 0.0251371670 0.112641013 16 74649194 74649202 9 - 2.118 2.021 -0.325
ENSG00000168411 E022 4.1440223 0.105793769 0.2644789266 0.503702343 16 74649203 74649243 41 - 0.749 0.593 -0.659
ENSG00000168411 E023 272.3635568 0.023163860 0.0052576753 0.035975430 16 74651920 74652122 203 - 2.469 2.343 -0.420
ENSG00000168411 E024 2.1239763 0.072721444 0.1791523346 0.402819027 16 74660600 74660779 180 - 0.577 0.346 -1.189
ENSG00000168411 E025 2.6051164 0.054113657 0.8630503793 0.932032283 16 74660780 74660931 152 - 0.548 0.541 -0.031
ENSG00000168411 E026 194.0734882 0.021423021 0.0009254656 0.009303027 16 74660932 74660997 66 - 2.336 2.164 -0.578
ENSG00000168411 E027 226.1260957 0.025288260 0.0014622068 0.013351059 16 74660998 74661081 84 - 2.402 2.232 -0.568
ENSG00000168411 E028 147.8998372 0.025547221 0.0019319726 0.016615688 16 74661082 74661100 19 - 2.221 2.042 -0.597
ENSG00000168411 E029 320.7880203 0.027878399 0.0676107585 0.219715540 16 74661101 74661451 351 - 2.519 2.454 -0.217
ENSG00000168411 E030 2.7655030 0.050376132 0.3775789884 0.610304065 16 74661956 74662040 85 - 0.606 0.486 -0.560
ENSG00000168411 E031 4.4738345 0.251522177 0.0425737143 0.161427076 16 74664335 74664623 289 - 0.842 0.428 -1.823
ENSG00000168411 E032 60.8042160 0.009195350 0.2698187138 0.509752030 16 74664624 74664689 66 - 1.718 1.852 0.451
ENSG00000168411 E033 53.0647513 0.001003380 0.0151294247 0.078582221 16 74664690 74664745 56 - 1.641 1.810 0.572
ENSG00000168411 E034 0.9576510 0.016150776 0.6532966433   16 74665233 74665280 48 - 0.245 0.349 0.702
ENSG00000168411 E035 0.6731895 0.040119104 0.5179477878   16 74666305 74666785 481 - 0.246 0.150 -0.884
ENSG00000168411 E036 72.6848220 0.010681527 0.9624893415 0.983198295 16 74666786 74666841 56 - 1.823 1.893 0.235
ENSG00000168411 E037 45.4062057 0.001580030 0.4830421875 0.689179633 16 74666842 74666883 42 - 1.646 1.655 0.032