ENSG00000168395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313552 ENSG00000168395 HEK293_OSMI2_6hA HEK293_TMG_6hB ING5 protein_coding protein_coding 33.92086 36.44939 30.82934 1.148998 1.387363 -0.2415185 11.150768 11.185281 9.405534 0.2598413 0.6476899 -0.2497758 0.32991250 0.30786667 0.30443333 -0.0034333333 1.000000000 0.0001386352 FALSE TRUE
ENST00000406941 ENSG00000168395 HEK293_OSMI2_6hA HEK293_TMG_6hB ING5 protein_coding protein_coding 33.92086 36.44939 30.82934 1.148998 1.387363 -0.2415185 5.104368 5.742425 4.901285 1.5311532 0.9034656 -0.2280695 0.15013333 0.15883333 0.15806667 -0.0007666667 1.000000000 0.0001386352 FALSE TRUE
ENST00000489509 ENSG00000168395 HEK293_OSMI2_6hA HEK293_TMG_6hB ING5 protein_coding retained_intron 33.92086 36.44939 30.82934 1.148998 1.387363 -0.2415185 1.895259 2.877525 1.533144 0.4938111 0.2649760 -0.9039605 0.05515833 0.07883333 0.04946667 -0.0293666667 0.517228947 0.0001386352 FALSE TRUE
ENST00000492488 ENSG00000168395 HEK293_OSMI2_6hA HEK293_TMG_6hB ING5 protein_coding retained_intron 33.92086 36.44939 30.82934 1.148998 1.387363 -0.2415185 2.637052 3.108001 2.064600 0.6314486 0.2560608 -0.5877884 0.07697917 0.08563333 0.06780000 -0.0178333333 0.869853896 0.0001386352 FALSE TRUE
ENST00000493261 ENSG00000168395 HEK293_OSMI2_6hA HEK293_TMG_6hB ING5 protein_coding retained_intron 33.92086 36.44939 30.82934 1.148998 1.387363 -0.2415185 3.747634 1.926701 7.072548 0.5300474 0.8269213 1.8706671 0.11507500 0.05340000 0.22956667 0.1761666667 0.004181936 0.0001386352 FALSE TRUE
MSTRG.20200.1 ENSG00000168395 HEK293_OSMI2_6hA HEK293_TMG_6hB ING5 protein_coding   33.92086 36.44939 30.82934 1.148998 1.387363 -0.2415185 4.603885 4.803988 3.079810 0.5475510 0.3369972 -0.6397143 0.13439583 0.13110000 0.09930000 -0.0318000000 0.554521046 0.0001386352 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168395 E001 10.102036 0.0579001906 3.250548e-05 0.0005779081 2 241687056 241687084 29 + 0.471 1.218 2.986
ENSG00000168395 E002 57.808916 0.4763217923 1.000457e-01 0.2818712135 2 241687085 241687820 736 + 1.446 1.887 1.500
ENSG00000168395 E003 19.783291 0.2143564312 9.883799e-02 0.2797587297 2 241687821 241687908 88 + 1.053 1.422 1.304
ENSG00000168395 E004 41.889182 0.5008315052 2.451361e-01 0.4824736180 2 241687909 241688062 154 + 1.428 1.716 0.984
ENSG00000168395 E005 8.175130 0.1259254276 3.540854e-01 0.5909078872 2 241688312 241688332 21 + 0.832 1.015 0.692
ENSG00000168395 E006 106.548275 0.0505888877 3.930780e-01 0.6228474731 2 241689838 241690413 576 + 1.957 2.061 0.350
ENSG00000168395 E007 66.491870 0.0156036856 4.959563e-01 0.6981733113 2 241690414 241690653 240 + 1.770 1.848 0.264
ENSG00000168395 E008 25.010780 0.0170567341 1.042653e-01 0.2893210092 2 241694115 241694289 175 + 1.291 1.465 0.603
ENSG00000168395 E009 13.761022 0.2881556434 9.757294e-01 0.9896691061 2 241700065 241701961 1897 + 1.215 1.115 -0.359
ENSG00000168395 E010 6.932174 0.0045751678 1.574351e-01 0.3728676198 2 241701962 241702034 73 + 0.758 0.952 0.750
ENSG00000168395 E011 7.543483 0.0043461988 5.389870e-01 0.7283029275 2 241702035 241702038 4 + 0.863 0.951 0.335
ENSG00000168395 E012 7.864102 0.0047256624 8.046367e-01 0.8989740151 2 241702039 241702041 3 + 0.908 0.951 0.165
ENSG00000168395 E013 11.548064 0.0167353287 7.546937e-01 0.8694992847 2 241702042 241702045 4 + 1.095 1.075 -0.070
ENSG00000168395 E014 53.992163 0.0007040341 1.021668e-02 0.0590549131 2 241702046 241702060 15 + 1.795 1.687 -0.366
ENSG00000168395 E015 76.788374 0.0038780990 6.559224e-03 0.0424993174 2 241702061 241702064 4 + 1.950 1.833 -0.393
ENSG00000168395 E016 102.952218 0.0025597446 3.088806e-02 0.1300129449 2 241702065 241702102 38 + 2.052 1.979 -0.244
ENSG00000168395 E017 166.472180 0.0064738450 6.299059e-02 0.2094312689 2 241704653 241704724 72 + 2.255 2.187 -0.225
ENSG00000168395 E018 1.220672 0.1409520690 8.577480e-01   2 241709086 241709215 130 + 0.340 0.318 -0.139
ENSG00000168395 E019 250.232550 0.0094343792 1.198126e-01 0.3155590909 2 241709216 241709382 167 + 2.425 2.367 -0.192
ENSG00000168395 E020 169.686233 0.0110168463 3.758863e-01 0.6089301063 2 241711377 241711488 112 + 2.241 2.211 -0.100
ENSG00000168395 E021 7.455155 0.0180627628 5.932544e-03 0.0394132885 2 241711489 241711584 96 + 1.080 0.743 -1.283
ENSG00000168395 E022 5.070730 0.0856735569 3.661802e-01 0.6009150284 2 241711585 241711623 39 + 0.838 0.708 -0.521
ENSG00000168395 E023 146.484718 0.0107313553 5.488476e-01 0.7355336695 2 241711978 241712071 94 + 2.168 2.153 -0.049
ENSG00000168395 E024 15.621710 0.0038427675 2.052825e-01 0.4362237944 2 241712072 241712380 309 + 1.133 1.265 0.468
ENSG00000168395 E025 14.213948 0.0225329210 2.653407e-01 0.5047206618 2 241719483 241719612 130 + 1.091 1.231 0.499
ENSG00000168395 E026 29.408091 0.0027523817 1.967596e-03 0.0168512327 2 241719613 241719919 307 + 1.323 1.561 0.818
ENSG00000168395 E027 57.434723 0.0177162894 6.573847e-02 0.2156026410 2 241719976 241720740 765 + 1.648 1.815 0.565
ENSG00000168395 E028 56.010908 0.0024224200 1.119355e-01 0.3023050951 2 241720741 241721430 690 + 1.680 1.782 0.346
ENSG00000168395 E029 19.424013 0.0041850599 5.040944e-01 0.7036678117 2 241721431 241721805 375 + 1.253 1.325 0.251
ENSG00000168395 E030 163.742742 0.0103064593 8.406072e-01 0.9197658659 2 241722939 241723074 136 + 2.196 2.217 0.069
ENSG00000168395 E031 138.522869 0.0633849597 5.647077e-01 0.7465909544 2 241723210 241723271 62 + 2.107 2.154 0.156
ENSG00000168395 E032 23.329830 0.0377615372 7.969258e-01 0.8945282041 2 241723791 241724038 248 + 1.360 1.396 0.124
ENSG00000168395 E033 514.841439 0.0181979828 3.619823e-01 0.5973348278 2 241724989 241726447 1459 + 2.667 2.726 0.196
ENSG00000168395 E034 109.036031 0.0040566496 1.092764e-01 0.2979264012 2 241726448 241726783 336 + 2.063 2.011 -0.175
ENSG00000168395 E035 246.309241 0.0039601639 7.518231e-02 0.2352059616 2 241726784 241727742 959 + 2.409 2.365 -0.149
ENSG00000168395 E036 44.372855 0.0083057866 8.421057e-01 0.9206411342 2 241727743 241727767 25 + 1.625 1.656 0.106
ENSG00000168395 E037 108.106447 0.0051463921 2.150860e-01 0.4476786250 2 241727768 241727945 178 + 2.050 2.011 -0.133
ENSG00000168395 E038 222.800630 0.0025124611 3.910642e-01 0.6211983348 2 241727946 241728499 554 + 2.345 2.334 -0.036
ENSG00000168395 E039 276.824227 0.0024456970 7.643520e-01 0.8752481628 2 241728500 241729478 979 + 2.417 2.444 0.090