ENSG00000168259

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457167 ENSG00000168259 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC7 protein_coding protein_coding 99.87029 81.94001 114.1259 16.00873 5.513568 0.477937 23.730833 22.88699 23.230317 5.060531 0.9736228 0.02147168 0.23712917 0.2774667 0.20450000 -0.07296667 2.668038e-01 1.402833e-13 FALSE  
ENST00000674214 ENSG00000168259 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC7 protein_coding protein_coding 99.87029 81.94001 114.1259 16.00873 5.513568 0.477937 61.322049 49.09609 69.558068 10.222226 5.2006420 0.50252331 0.61513333 0.5954667 0.60786667 0.01240000 9.589543e-01 1.402833e-13 FALSE  
ENST00000674411 ENSG00000168259 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC7 protein_coding protein_coding 99.87029 81.94001 114.1259 16.00873 5.513568 0.477937 2.156817 0.00000 7.072835 0.000000 1.6545587 9.46818311 0.01867083 0.0000000 0.06253333 0.06253333 1.402833e-13 1.402833e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168259 E001 0.0000000       17 41976421 41976434 14 -      
ENSG00000168259 E002 4.5118927 0.0078921506 5.066810e-03 0.034973820 17 41976435 41976456 22 - 0.494 0.931 1.830
ENSG00000168259 E003 6.6259695 0.0046818642 1.706432e-04 0.002341729 17 41976457 41976472 16 - 0.571 1.090 2.053
ENSG00000168259 E004 7.5474635 0.0129154340 9.647691e-05 0.001450682 17 41976473 41976478 6 - 0.605 1.146 2.103
ENSG00000168259 E005 7.5474635 0.0129154340 9.647691e-05 0.001450682 17 41976479 41976479 1 - 0.605 1.146 2.103
ENSG00000168259 E006 7.8515138 0.0174401653 5.946234e-04 0.006533010 17 41976480 41976492 13 - 0.665 1.146 1.841
ENSG00000168259 E007 8.4596145 0.0365134017 1.119397e-02 0.063163136 17 41976493 41976494 2 - 0.764 1.144 1.428
ENSG00000168259 E008 8.7932169 0.0203360052 3.587618e-03 0.026862135 17 41976495 41976500 6 - 0.765 1.166 1.501
ENSG00000168259 E009 10.4768374 0.0831499630 2.969417e-02 0.126419661 17 41976501 41976522 22 - 0.858 1.220 1.327
ENSG00000168259 E010 8.0485595 0.0828584460 1.746513e-01 0.396701798 17 41976523 41976526 4 - 0.841 1.073 0.868
ENSG00000168259 E011 7.7750567 0.0633306811 1.494397e-01 0.361457498 17 41976527 41976527 1 - 0.824 1.062 0.896
ENSG00000168259 E012 7.9294578 0.1052707953 2.610946e-01 0.500139595 17 41976528 41976528 1 - 0.857 1.049 0.719
ENSG00000168259 E013 8.5365630 0.1083589881 2.148953e-01 0.447429725 17 41976529 41976530 2 - 0.874 1.086 0.789
ENSG00000168259 E014 9.2157220 0.1178109186 2.240700e-01 0.458239794 17 41976531 41976534 4 - 0.906 1.111 0.758
ENSG00000168259 E015 10.9084319 0.0551098705 4.818364e-02 0.175439860 17 41976535 41976537 3 - 0.911 1.219 1.122
ENSG00000168259 E016 15.1775664 0.1947680306 2.004045e-01 0.430248110 17 41976538 41976540 3 - 1.075 1.324 0.885
ENSG00000168259 E017 30.1431318 0.4506509795 2.936614e-01 0.534311045 17 41976541 41976544 4 - 1.379 1.593 0.733
ENSG00000168259 E018 152.2997179 1.2245567623 3.869214e-01 0.618055755 17 41976545 41976564 20 - 2.035 2.307 0.908
ENSG00000168259 E019 189.6678664 1.3036833809 4.026472e-01 0.630492033 17 41976565 41976572 8 - 2.132 2.400 0.893
ENSG00000168259 E020 198.9151840 1.3174437496 3.970639e-01 0.625992334 17 41976573 41976580 8 - 2.147 2.424 0.923
ENSG00000168259 E021 459.7572610 1.6093755569 4.561762e-01 0.670369183 17 41976581 41976677 97 - 2.521 2.780 0.861
ENSG00000168259 E022 526.3244224 1.6557460978 4.687101e-01 0.679163828 17 41976678 41976739 62 - 2.583 2.836 0.844
ENSG00000168259 E023 376.7413562 1.5387162516 4.371227e-01 0.656532682 17 41976740 41976770 31 - 2.427 2.698 0.901
ENSG00000168259 E024 3.0652084 0.0977430797 1.399900e-01 0.347489829 17 41976777 41976800 24 - 0.448 0.758 1.387
ENSG00000168259 E025 478.7823477 1.6137866101 4.417817e-01 0.659952616 17 41977261 41977323 63 - 2.525 2.805 0.933
ENSG00000168259 E026 1.8201430 0.2029544819 4.780697e-01 0.685841975 17 41981479 41981854 376 - 0.344 0.538 1.020
ENSG00000168259 E027 867.0208901 0.0081932036 9.822319e-02 0.278659497 17 41981855 41982007 153 - 2.883 2.993 0.364
ENSG00000168259 E028 0.6486114 0.0194939243 3.051514e-01   17 41982246 41982249 4 - 0.115 0.308 1.766
ENSG00000168259 E029 0.9338807 0.0701934583 9.412716e-01   17 41982250 41982254 5 - 0.279 0.308 0.193
ENSG00000168259 E030 910.4441612 0.0039304701 2.043110e-01 0.435019385 17 41982255 41982401 147 - 2.955 2.965 0.033
ENSG00000168259 E031 3.1183612 0.2430771181 8.403291e-01 0.919623957 17 41982402 41982601 200 - 0.566 0.658 0.406
ENSG00000168259 E032 599.2246065 0.0098454542 1.956335e-01 0.424147711 17 41983563 41983617 55 - 2.786 2.770 -0.054
ENSG00000168259 E033 463.8731947 0.0091755414 2.171165e-01 0.449992290 17 41983618 41983636 19 - 2.673 2.661 -0.038
ENSG00000168259 E034 61.0433779 0.1748355256 7.334830e-01 0.856327237 17 41983637 41986067 2431 - 1.780 1.804 0.082
ENSG00000168259 E035 0.6246688 0.0192289246 4.010792e-02   17 41986561 41986565 5 - 0.345 0.000 -12.843
ENSG00000168259 E036 0.7970432 0.0172671820 1.799270e-01   17 41986566 41986572 7 - 0.345 0.128 -1.820
ENSG00000168259 E037 1.1252237 0.4905638315 7.859528e-01   17 41986573 41986591 19 - 0.341 0.313 -0.174
ENSG00000168259 E038 25.7391554 0.2399035737 3.432238e-01 0.580894961 17 41986592 41987594 1003 - 1.472 1.369 -0.356
ENSG00000168259 E039 9.4056230 0.0360087773 2.538202e-01 0.492190563 17 41987595 41987676 82 - 1.067 0.949 -0.434
ENSG00000168259 E040 6.3970634 0.0441540413 3.094808e-01 0.549977666 17 41987677 41987694 18 - 0.920 0.809 -0.427
ENSG00000168259 E041 7.4200433 0.1155816903 5.558252e-01 0.740382268 17 41987695 41987818 124 - 0.953 0.882 -0.268
ENSG00000168259 E042 676.1600787 0.0122455485 2.373157e-01 0.473457459 17 41987819 41987905 87 - 2.836 2.824 -0.041
ENSG00000168259 E043 338.5842770 0.0099942784 2.693059e-01 0.509106454 17 41987906 41987910 5 - 2.533 2.529 -0.012
ENSG00000168259 E044 25.3449090 0.1799784537 3.388409e-01 0.576970373 17 41987911 41988731 821 - 1.476 1.346 -0.451
ENSG00000168259 E045 557.7131692 0.0091581907 2.099904e-01 0.441827169 17 41988732 41988786 55 - 2.751 2.743 -0.024
ENSG00000168259 E046 335.7240096 0.0052371472 8.962336e-02 0.263109718 17 41988787 41988787 1 - 2.535 2.519 -0.051
ENSG00000168259 E047 690.4968790 0.0087912085 7.255397e-02 0.229889134 17 41988788 41988873 86 - 2.852 2.825 -0.091
ENSG00000168259 E048 491.3221702 0.0088816194 3.023788e-02 0.128053844 17 41988874 41988896 23 - 2.714 2.666 -0.159
ENSG00000168259 E049 450.2110045 0.0089849649 4.983970e-02 0.179259720 17 41989404 41989418 15 - 2.673 2.633 -0.135
ENSG00000168259 E050 713.5250330 0.0112903696 1.375126e-01 0.343713722 17 41989419 41989557 139 - 2.863 2.843 -0.067
ENSG00000168259 E051 521.8500301 0.0086902945 1.402818e-01 0.347949944 17 41990264 41990382 119 - 2.724 2.711 -0.043
ENSG00000168259 E052 0.1426347 0.0316334713 5.029504e-01   17 41992608 41992798 191 - 0.115 0.000 -10.843
ENSG00000168259 E053 0.0000000       17 41992799 41992867 69 -      
ENSG00000168259 E054 257.2467647 0.0074112881 9.356477e-02 0.270352881 17 41994870 41994874 5 - 2.423 2.400 -0.077
ENSG00000168259 E055 423.9791209 0.0100697854 9.124678e-02 0.265967563 17 41994875 41994944 70 - 2.641 2.613 -0.095
ENSG00000168259 E056 0.7282998 0.5283811349 9.611605e-01   17 41994945 41994983 39 - 0.207 0.238 0.260
ENSG00000168259 E057 0.7088986 0.1774699595 3.241394e-01   17 41995819 41996310 492 - 0.115 0.312 1.791
ENSG00000168259 E058 326.1438450 0.0058669085 2.490321e-03 0.020270999 17 41996311 41996325 15 - 2.547 2.477 -0.233
ENSG00000168259 E059 508.2500826 0.0050080319 6.018969e-03 0.039813015 17 41996326 41996424 99 - 2.729 2.681 -0.162
ENSG00000168259 E060 316.2897037 0.0040858655 1.797996e-03 0.015686675 17 41997115 41997136 22 - 2.530 2.469 -0.204
ENSG00000168259 E061 453.7462492 0.0002791169 5.929438e-04 0.006517086 17 41997137 41997239 103 - 2.668 2.655 -0.046
ENSG00000168259 E062 296.8453649 0.0076153702 7.932374e-01 0.892307447 17 42000482 42000556 75 - 2.463 2.490 0.088
ENSG00000168259 E063 176.8604692 0.0709809994 5.611804e-01 0.744111568 17 42000557 42000570 14 - 2.220 2.282 0.207
ENSG00000168259 E064 0.3503582 0.0718497241 9.960719e-01   17 42000956 42001066 111 - 0.115 0.128 0.178
ENSG00000168259 E065 7.7061955 0.0040254731 1.362129e-01 0.341695236 17 42003359 42003557 199 - 1.004 0.876 -0.482
ENSG00000168259 E066 0.5474829 0.2298672542 1.047188e-01   17 42011051 42011275 225 - 0.000 0.313 12.788
ENSG00000168259 E067 0.9935478 0.6808273277 7.979104e-01   17 42012982 42015554 2573 - 0.204 0.384 1.249
ENSG00000168259 E068 1.3734580 0.3620237811 1.150461e-01   17 42015555 42016586 1032 - 0.116 0.540 3.006
ENSG00000168259 E069 0.9815936 0.0316786131 8.254329e-03   17 42016587 42017039 453 - 0.000 0.486 13.753
ENSG00000168259 E070 3.3324386 0.3015278647 8.477034e-01 0.923693835 17 42017040 42017051 12 - 0.636 0.658 0.096
ENSG00000168259 E071 17.8644278 0.3017501559 3.416133e-01 0.579435250 17 42017052 42017339 288 - 1.187 1.360 0.608
ENSG00000168259 E072 184.5682201 1.3360864088 4.867670e-01 0.691733481 17 42017340 42017622 283 - 2.169 2.356 0.623
ENSG00000168259 E073 14.8313855 0.0087478508 4.493769e-03 0.031903329 17 42017675 42017862 188 - 1.028 1.341 1.115
ENSG00000168259 E074 20.2632967 0.0020739691 1.687278e-02 0.084983424 17 42018438 42018526 89 - 1.397 1.259 -0.482
ENSG00000168259 E075 0.0000000       17 42021323 42021376 54 -