ENSG00000168071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301897 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding protein_coding 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.39626261 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.19583333 0.00000000 0.00000000 0.00000000   0.008029376 FALSE TRUE
ENST00000356786 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding protein_coding 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.18849210 0.32906406 0.07404744 0.06083499 0.01754887 -2.0122820 0.20212083 0.19880000 0.42796667 0.22916667 0.738073088 0.008029376 FALSE TRUE
ENST00000359902 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding protein_coding 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.07462293 0.21939356 0.00000000 0.11044785 0.00000000 -4.5197530 0.03691250 0.12240000 0.00000000 -0.12240000 0.771301635 0.008029376 FALSE TRUE
ENST00000463837 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding processed_transcript 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.04783390 0.07203751 0.00000000 0.05339292 0.00000000 -3.0362837 0.05331250 0.03833333 0.00000000 -0.03833333 1.000000000 0.008029376 TRUE TRUE
ENST00000472524 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding processed_transcript 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.37746964 0.70982987 0.00000000 0.06231894 0.00000000 -6.1695841 0.21806667 0.42193333 0.00000000 -0.42193333 0.008029376 0.008029376 FALSE TRUE
ENST00000479965 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding processed_transcript 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.05941313 0.06507603 0.03521655 0.01677756 0.03521655 -0.7315015 0.06678333 0.03936667 0.07773333 0.03836667 0.726661444 0.008029376 FALSE TRUE
ENST00000492980 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding processed_transcript 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.03927734 0.00000000 0.10926510 0.00000000 0.09541552 3.5761000 0.06752500 0.00000000 0.29000000 0.29000000 0.096772054 0.008029376 FALSE TRUE
ENST00000494080 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding processed_transcript 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.06626718 0.12032694 0.00000000 0.06019189 0.00000000 -3.7040634 0.05337500 0.07010000 0.00000000 -0.07010000 0.785514421 0.008029376 TRUE TRUE
ENST00000494566 ENSG00000168071 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88B protein_coding processed_transcript 1.365905 1.711167 0.2537396 0.1179992 0.1001968 -2.706201 0.10533512 0.19543920 0.03521055 0.08798867 0.03521055 -2.1839802 0.09557083 0.10903333 0.20430000 0.09526667 1.000000000 0.008029376 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168071 E001 0.0000000       11 64340204 64340222 19 +      
ENSG00000168071 E002 0.1779838 0.031894050 0.0358197224   11 64340223 64340326 104 + 0.275 0.000 -13.090
ENSG00000168071 E003 0.0000000       11 64340607 64340752 146 +      
ENSG00000168071 E004 1.2967903 0.025006025 0.2400187875   11 64340907 64341018 112 + 0.442 0.233 -1.317
ENSG00000168071 E005 1.9934450 0.077755151 0.0545945886 0.190444429 11 64341109 64341178 70 + 0.655 0.312 -1.743
ENSG00000168071 E006 2.0597743 0.011047387 0.0081568155 0.050048763 11 64341270 64341328 59 + 0.734 0.288 -2.228
ENSG00000168071 E007 2.2916280 0.010218503 0.2308563883 0.466154728 11 64341421 64341504 84 + 0.562 0.361 -1.032
ENSG00000168071 E008 0.6479912 0.038217387 1.0000000000   11 64341599 64341605 7 + 0.000 0.168 12.921
ENSG00000168071 E009 1.3673712 0.102410824 0.3191930504   11 64341606 64341742 137 + 0.440 0.260 -1.100
ENSG00000168071 E010 1.1657345 0.017745046 0.7425032197   11 64341994 64342139 146 + 0.275 0.233 -0.317
ENSG00000168071 E011 1.0119535 0.015722139 0.6234043607   11 64342294 64342375 82 + 0.000 0.232 13.379
ENSG00000168071 E012 0.0000000       11 64342502 64342521 20 +      
ENSG00000168071 E013 1.2433299 0.014394814 0.4197319143   11 64342522 64342680 159 + 0.000 0.288 13.688
ENSG00000168071 E014 0.1723744 0.031827500 0.6572451426   11 64342731 64342807 77 + 0.000 0.048 11.265
ENSG00000168071 E015 2.3972979 0.009788181 0.1394319375 0.346659942 11 64343179 64343325 147 + 0.000 0.442 14.353
ENSG00000168071 E016 0.0000000       11 64343326 64343330 5 +      
ENSG00000168071 E017 1.6599447 0.012002485 0.2966742738 0.537183687 11 64343507 64343538 32 + 0.000 0.338 13.929
ENSG00000168071 E018 2.1244152 0.009655574 0.1849994432 0.410531576 11 64343539 64343615 77 + 0.000 0.404 14.205
ENSG00000168071 E019 3.0812584 0.007937802 0.4211582666 0.644502398 11 64343778 64343914 137 + 0.275 0.494 1.263
ENSG00000168071 E020 16.5076844 0.003316919 0.0001778817 0.002424394 11 64343997 64345157 1161 + 1.329 1.013 -1.127
ENSG00000168071 E021 0.0000000       11 64348831 64349052 222 +      
ENSG00000168071 E022 5.3871631 0.064795353 0.8124467771 0.903667411 11 64349331 64349458 128 + 0.560 0.651 0.403
ENSG00000168071 E023 5.0360649 0.185932057 0.9155684311 0.959941334 11 64349551 64349668 118 + 0.557 0.626 0.311
ENSG00000168071 E024 1.4877580 0.015304173 0.9720036528 0.987919924 11 64349669 64349890 222 + 0.275 0.289 0.096
ENSG00000168071 E025 4.1380575 0.227821844 0.4222042681 0.645300604 11 64349891 64350695 805 + 0.663 0.543 -0.534
ENSG00000168071 E026 5.0338698 0.217475416 0.6711246839 0.817042733 11 64351160 64351255 96 + 0.724 0.613 -0.468
ENSG00000168071 E027 1.9024674 0.239324815 0.3572163856 0.593442702 11 64351256 64351475 220 + 0.000 0.380 14.041
ENSG00000168071 E028 4.9782592 0.095161765 0.9089193382 0.956525081 11 64351476 64351616 141 + 0.559 0.639 0.356
ENSG00000168071 E029 5.9845331 0.005334830 0.0696238523 0.224019164 11 64352130 64352386 257 + 0.275 0.719 2.263
ENSG00000168071 E030 4.3597450 0.051655823 0.2543358487 0.492790216 11 64352744 64352885 142 + 0.275 0.599 1.750
ENSG00000168071 E031 2.1659214 0.009937133 0.1853057925 0.410959002 11 64352886 64352887 2 + 0.000 0.404 14.206
ENSG00000168071 E032 1.0646060 0.333764823 0.8838186503   11 64352888 64353053 166 + 0.000 0.240 13.327
ENSG00000168071 E033 5.4022460 0.034690391 0.4435467408 0.661082825 11 64353054 64353240 187 + 0.442 0.660 1.015
ENSG00000168071 E034 0.3751086 0.027442404 1.0000000000   11 64353241 64353350 110 + 0.000 0.092 12.122
ENSG00000168071 E035 3.8639285 0.068885626 0.6670931677 0.814410535 11 64353351 64353420 70 + 0.563 0.519 -0.208
ENSG00000168071 E036 3.9341495 0.008133366 0.1167237953 0.310359479 11 64353421 64353496 76 + 0.734 0.495 -1.056
ENSG00000168071 E037 3.9514578 0.014071330 0.3658940847 0.600672388 11 64353715 64353813 99 + 0.657 0.526 -0.587
ENSG00000168071 E038 2.0185578 0.015117198 0.5204855129 0.715260089 11 64354004 64354028 25 + 0.442 0.338 -0.583
ENSG00000168071 E039 2.1261329 0.093989763 0.2289768344 0.463939259 11 64354029 64354170 142 + 0.000 0.389 14.118
ENSG00000168071 E040 6.0883118 0.109535781 0.1070374182 0.294040290 11 64355194 64355342 149 + 0.276 0.728 2.295
ENSG00000168071 E041 6.8579302 0.110113157 0.2546966874 0.493197855 11 64355343 64355400 58 + 0.443 0.760 1.420
ENSG00000168071 E042 3.2976694 0.204828421 0.9133741347 0.958777209 11 64355401 64355559 159 + 0.446 0.494 0.242
ENSG00000168071 E043 8.0072663 0.037623782 0.1208261435 0.317154089 11 64355560 64355628 69 + 0.442 0.810 1.626
ENSG00000168071 E044 0.9815936 0.015798839 0.6275949334   11 64355629 64357038 1410 + 0.000 0.232 13.378
ENSG00000168071 E045 16.6634078 0.002588681 0.0890489960 0.261994207 11 64357039 64357534 496 + 0.799 1.090 1.095