ENSG00000168066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377390 ENSG00000168066 HEK293_OSMI2_6hA HEK293_TMG_6hB SF1 protein_coding protein_coding 321.4881 341.9946 300.3281 47.31304 5.972062 -0.1874281 61.34642 71.26006 32.99712 15.447252 11.740858 -1.1105188 0.1843792 0.2029333 0.1084667 -0.09446667 5.373611e-01 7.156012e-06 FALSE TRUE
ENST00000486960 ENSG00000168066 HEK293_OSMI2_6hA HEK293_TMG_6hB SF1 protein_coding retained_intron 321.4881 341.9946 300.3281 47.31304 5.972062 -0.1874281 29.59745 23.89013 41.77589 6.341743 3.904729 0.8059975 0.1002250 0.0793000 0.1395667 0.06026667 5.087848e-01 7.156012e-06 FALSE FALSE
ENST00000489544 ENSG00000168066 HEK293_OSMI2_6hA HEK293_TMG_6hB SF1 protein_coding processed_transcript 321.4881 341.9946 300.3281 47.31304 5.972062 -0.1874281 68.61006 69.72901 94.21829 10.881003 1.800147 0.4341943 0.2185458 0.2030667 0.3137333 0.11066667 7.156012e-06 7.156012e-06 FALSE FALSE
MSTRG.5681.14 ENSG00000168066 HEK293_OSMI2_6hA HEK293_TMG_6hB SF1 protein_coding   321.4881 341.9946 300.3281 47.31304 5.972062 -0.1874281 28.80832 27.88794 48.56625 3.705106 7.439788 0.8000922 0.0942000 0.0818000 0.1628333 0.08103333 9.724600e-02 7.156012e-06 FALSE TRUE
MSTRG.5681.9 ENSG00000168066 HEK293_OSMI2_6hA HEK293_TMG_6hB SF1 protein_coding   321.4881 341.9946 300.3281 47.31304 5.972062 -0.1874281 93.02829 111.96697 31.79759 25.813801 9.032469 -1.8157591 0.2729792 0.3172667 0.1048000 -0.21246667 4.517113e-02 7.156012e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000168066 E001 38.328977 0.187760381 3.452292e-02 1.402681e-01 11 64764606 64764610 5 - 1.236 1.688 1.556
ENSG00000168066 E002 70.661652 0.448697459 1.580672e-01 3.738581e-01 11 64764611 64764621 11 - 1.557 1.934 1.275
ENSG00000168066 E003 678.308790 1.589214706 5.176917e-01 7.134067e-01 11 64764622 64764687 66 - 2.659 2.876 0.721
ENSG00000168066 E004 1058.462084 1.699451425 4.829126e-01 6.890641e-01 11 64764688 64764735 48 - 2.811 3.081 0.899
ENSG00000168066 E005 1006.122635 1.694190306 4.982611e-01 6.996361e-01 11 64764736 64764753 18 - 2.804 3.055 0.834
ENSG00000168066 E006 956.683838 1.678771884 4.968555e-01 6.987900e-01 11 64764754 64764754 1 - 2.783 3.033 0.832
ENSG00000168066 E007 1061.701276 1.700869266 4.831594e-01 6.892481e-01 11 64764755 64764760 6 - 2.813 3.082 0.894
ENSG00000168066 E008 2191.623894 1.898840905 4.683227e-01 6.789189e-01 11 64764761 64764975 215 - 3.095 3.406 1.032
ENSG00000168066 E009 654.767974 1.504545019 3.970643e-01 6.259923e-01 11 64764976 64764980 5 - 2.550 2.887 1.122
ENSG00000168066 E010 2666.223914 1.958197751 4.736644e-01 6.825318e-01 11 64764981 64765289 309 - 3.182 3.490 1.026
ENSG00000168066 E011 1858.108619 1.861187764 4.791297e-01 6.865069e-01 11 64765290 64765518 229 - 3.043 3.329 0.950
ENSG00000168066 E012 599.894592 1.488958926 4.078856e-01 6.343721e-01 11 64765519 64765603 85 - 2.529 2.845 1.049
ENSG00000168066 E013 443.227161 1.412381527 4.323739e-01 6.530124e-01 11 64765604 64765651 48 - 2.431 2.704 0.911
ENSG00000168066 E014 708.263896 1.582059242 4.781754e-01 6.859125e-01 11 64765652 64765950 299 - 2.653 2.902 0.828
ENSG00000168066 E015 275.618123 1.254087591 3.794601e-01 6.117741e-01 11 64765951 64766020 70 - 2.197 2.506 1.031
ENSG00000168066 E016 380.939353 1.359850085 4.204983e-01 6.440437e-01 11 64766021 64766155 135 - 2.364 2.639 0.919
ENSG00000168066 E017 40.123188 0.150086905 3.958078e-01 6.250326e-01 11 64766414 64766899 486 - 1.636 1.569 -0.228
ENSG00000168066 E018 905.341410 0.008208137 7.668107e-03 4.779318e-02 11 64766900 64767079 180 - 2.816 2.991 0.582
ENSG00000168066 E019 690.082516 0.010255988 6.638962e-01 8.123312e-01 11 64767192 64767246 55 - 2.787 2.836 0.162
ENSG00000168066 E020 465.569262 0.008422365 2.394321e-01 4.759567e-01 11 64767247 64767251 5 - 2.639 2.654 0.051
ENSG00000168066 E021 4.657372 0.100170895 6.971245e-01 8.336754e-01 11 64767252 64767275 24 - 0.760 0.726 -0.138
ENSG00000168066 E022 36.042124 0.012056573 8.927735e-01 9.480106e-01 11 64767567 64767570 4 - 1.510 1.561 0.174
ENSG00000168066 E023 1992.016891 0.015030090 6.706534e-01 8.167431e-01 11 64767571 64767844 274 - 3.248 3.295 0.155
ENSG00000168066 E024 1193.815690 0.012191998 8.313033e-01 9.145376e-01 11 64768106 64768170 65 - 3.018 3.076 0.195
ENSG00000168066 E025 1691.598632 0.008851959 7.089681e-02 2.265062e-01 11 64768171 64768286 116 - 3.215 3.204 -0.034
ENSG00000168066 E026 1869.050568 0.010588810 3.606975e-02 1.444032e-01 11 64769022 64769129 108 - 3.273 3.239 -0.110
ENSG00000168066 E027 1722.389706 0.010882037 1.053048e-02 6.037513e-02 11 64769223 64769277 55 - 3.253 3.194 -0.197
ENSG00000168066 E028 1811.748436 0.009906514 1.305534e-02 7.066445e-02 11 64769278 64769338 61 - 3.269 3.220 -0.162
ENSG00000168066 E029 2537.452807 0.013639378 4.384115e-02 1.647140e-01 11 64769426 64769541 116 - 3.410 3.369 -0.135
ENSG00000168066 E030 1978.136571 0.013263213 1.543014e-02 7.970535e-02 11 64769542 64769609 68 - 3.317 3.252 -0.215
ENSG00000168066 E031 6.975900 0.018614113 8.146156e-01 9.050023e-01 11 64769610 64769669 60 - 0.822 0.903 0.309
ENSG00000168066 E032 2011.613218 0.017390029 3.847027e-02 1.507867e-01 11 64769964 64770053 90 - 3.323 3.260 -0.207
ENSG00000168066 E033 1236.615071 0.015680526 3.380877e-02 1.383462e-01 11 64770256 64770277 22 - 3.111 3.049 -0.206
ENSG00000168066 E034 1126.622352 0.014403042 4.070936e-02 1.565780e-01 11 64770278 64770296 19 - 3.065 3.012 -0.176
ENSG00000168066 E035 1550.072147 0.012895114 1.798690e-02 8.899022e-02 11 64770297 64770379 83 - 3.209 3.147 -0.206
ENSG00000168066 E036 1040.858426 0.010770705 1.632983e-02 8.301170e-02 11 64770380 64770408 29 - 3.034 2.976 -0.191
ENSG00000168066 E037 141.621189 0.174982254 1.193648e-01 3.148151e-01 11 64770409 64770639 231 - 2.261 2.045 -0.723
ENSG00000168066 E038 80.868250 0.145211638 2.629719e-02 1.161927e-01 11 64771464 64771537 74 - 2.079 1.745 -1.123
ENSG00000168066 E039 72.903276 0.207522436 2.370109e-02 1.081696e-01 11 64771538 64771607 70 - 2.061 1.668 -1.324
ENSG00000168066 E040 113.999782 0.213370693 1.719732e-02 8.616573e-02 11 64773023 64773429 407 - 2.267 1.841 -1.426
ENSG00000168066 E041 1248.616519 0.012227460 3.991052e-03 2.910644e-02 11 64773430 64773505 76 - 3.131 3.044 -0.291
ENSG00000168066 E042 62.451144 0.270845965 1.208197e-02 6.678592e-02 11 64776046 64776497 452 - 2.042 1.530 -1.732
ENSG00000168066 E043 1398.572818 0.010902195 1.684457e-02 8.488164e-02 11 64776498 64776626 129 - 3.158 3.107 -0.169
ENSG00000168066 E044 4.036104 0.011283834 5.159602e-01 7.122170e-01 11 64777499 64777520 22 - 0.728 0.683 -0.189
ENSG00000168066 E045 7.436700 0.167105273 9.463432e-01 9.755045e-01 11 64777521 64777761 241 - 0.877 0.937 0.226
ENSG00000168066 E046 62.293538 0.000704009 4.921999e-04 5.602336e-03 11 64777987 64778146 160 - 1.613 1.854 0.817
ENSG00000168066 E047 2.773219 0.017636084 8.180376e-03 5.015500e-02 11 64778147 64778149 3 - 0.157 0.703 3.209
ENSG00000168066 E048 28.325351 0.001592957 1.980356e-09 1.092270e-07 11 64778150 64778361 212 - 1.006 1.578 2.011
ENSG00000168066 E049 947.128719 0.010953673 9.257494e-02 2.685437e-01 11 64778362 64779844 1483 - 2.966 2.951 -0.050