ENSG00000167996

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526640 ENSG00000167996 HEK293_OSMI2_6hA HEK293_TMG_6hB FTH1 protein_coding protein_coding 1505.013 2096.786 681.3885 426.5267 17.72106 -1.621616 111.6471 154.6652 36.16964 34.98769 1.537502 -2.095992 0.0709625 0.07326667 0.05313333 -0.02013333 0.18939504 0.01075873 FALSE TRUE
ENST00000530019 ENSG00000167996 HEK293_OSMI2_6hA HEK293_TMG_6hB FTH1 protein_coding protein_coding 1505.013 2096.786 681.3885 426.5267 17.72106 -1.621616 349.1956 637.8421 106.44211 139.11660 15.066271 -2.583017 0.2368292 0.30250000 0.15710000 -0.14540000 0.03911736 0.01075873 FALSE FALSE
ENST00000620041 ENSG00000167996 HEK293_OSMI2_6hA HEK293_TMG_6hB FTH1 protein_coding protein_coding 1505.013 2096.786 681.3885 426.5267 17.72106 -1.621616 653.8988 895.7282 367.49473 209.60075 22.660675 -1.285314 0.4403875 0.42246667 0.53846667 0.11600000 0.22446950 0.01075873 FALSE TRUE
MSTRG.5584.9 ENSG00000167996 HEK293_OSMI2_6hA HEK293_TMG_6hB FTH1 protein_coding   1505.013 2096.786 681.3885 426.5267 17.72106 -1.621616 272.0982 313.3186 134.39777 45.12839 6.608595 -1.221060 0.1822208 0.15556667 0.19700000 0.04143333 0.55195056 0.01075873 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167996 E001 0.3032425 0.029094378 1.000000000   11 61959718 61959821 104 - 0.000 0.109 9.073
ENSG00000167996 E002 2.6779580 0.033625090 1.000000000 1.000000000 11 61959822 61959904 83 - 0.501 0.495 -0.033
ENSG00000167996 E003 0.7852089 1.064990014 1.000000000   11 61959905 61959927 23 - 0.000 0.242 10.453
ENSG00000167996 E004 49.0342990 0.012386513 0.671051151 0.817010694 11 61964285 61964565 281 - 1.623 1.555 -0.231
ENSG00000167996 E005 56.9634207 0.005211195 0.416622765 0.641157071 11 61964566 61964584 19 - 1.699 1.618 -0.276
ENSG00000167996 E006 235.5187920 0.300488364 0.511038496 0.708770319 11 61964585 61964600 16 - 2.287 2.233 -0.182
ENSG00000167996 E007 4635.2248940 1.611920743 0.594141585 0.766429917 11 61964601 61964746 146 - 3.563 3.527 -0.117
ENSG00000167996 E008 6734.3884395 1.738922438 0.607703776 0.775343363 11 61964747 61964837 91 - 3.724 3.690 -0.115
ENSG00000167996 E009 5626.9669860 1.680266723 0.605859266 0.774106657 11 61964838 61964891 54 - 3.650 3.611 -0.129
ENSG00000167996 E010 16.7361088 0.078429047 0.441025674 0.659490019 11 61964892 61964986 95 - 1.287 1.091 -0.696
ENSG00000167996 E011 3550.1861580 1.520667483 0.583584472 0.759340356 11 61964987 61964988 2 - 3.447 3.412 -0.118
ENSG00000167996 E012 8398.3883666 1.813920995 0.614972157 0.780255583 11 61964989 61965105 117 - 3.819 3.786 -0.111
ENSG00000167996 E013 4628.1574984 1.618894490 0.603999404 0.772858375 11 61965106 61965112 7 - 3.571 3.525 -0.155
ENSG00000167996 E014 38.3191415 0.149728251 0.063246802 0.210010200 11 61965113 61965368 256 - 1.853 1.326 -1.798
ENSG00000167996 E015 8389.3257430 1.801461506 0.593509505 0.766009536 11 61965369 61965515 147 - 3.804 3.788 -0.050
ENSG00000167996 E016 33.5296608 0.015801658 0.000117433 0.001708457 11 61965516 61965577 62 - 1.686 1.332 -1.216
ENSG00000167996 E017 24.6396818 0.137404961 0.007298154 0.046057021 11 61966989 61967311 323 - 1.621 1.172 -1.557
ENSG00000167996 E018 4962.7162130 0.001218642 0.187245495 0.413395899 11 61967312 61967371 60 - 3.542 3.568 0.086
ENSG00000167996 E019 3734.7977590 0.072498447 0.711817632 0.842971846 11 61967372 61967401 30 - 3.401 3.447 0.151
ENSG00000167996 E020 3794.8781238 0.137280987 0.942892941 0.973747022 11 61967402 61967453 52 - 3.357 3.462 0.347
ENSG00000167996 E021 2149.5979687 0.212951828 0.849275786 0.924529242 11 61967454 61967457 4 - 3.056 3.223 0.555
ENSG00000167996 E022 4122.7272511 0.283087125 0.797096849 0.894605078 11 61967458 61967547 90 - 3.433 3.491 0.195
ENSG00000167996 E023 2830.1522742 0.293959114 0.758883156 0.871860572 11 61967548 61967634 87 - 3.292 3.324 0.109