ENSG00000167969

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000563447 ENSG00000167969 HEK293_OSMI2_6hA HEK293_TMG_6hB ECI1 protein_coding retained_intron 162.5744 233.1407 78.84962 54.07427 1.83852 -1.563904 13.43223 17.04983 10.348721 3.316182 0.2889359 -0.7197573 0.09053333 0.07496667 0.13136667 0.05640000 0.0017576667 0.0001076929 FALSE  
ENST00000566379 ENSG00000167969 HEK293_OSMI2_6hA HEK293_TMG_6hB ECI1 protein_coding protein_coding 162.5744 233.1407 78.84962 54.07427 1.83852 -1.563904 14.87178 26.80976 3.189198 7.005917 0.5145834 -3.0675142 0.08573750 0.11310000 0.04033333 -0.07276667 0.0001076929 0.0001076929 FALSE  
MSTRG.11851.2 ENSG00000167969 HEK293_OSMI2_6hA HEK293_TMG_6hB ECI1 protein_coding   162.5744 233.1407 78.84962 54.07427 1.83852 -1.563904 123.22571 176.33787 56.655727 41.437333 1.2180725 -1.6378758 0.74702083 0.75470000 0.71860000 -0.03610000 0.3441690674 0.0001076929 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167969 E001 13.118674 3.665999e-03 4.623457e-06 1.075722e-04 16 2239402 2239662 261 - 1.373 0.919 -1.632
ENSG00000167969 E002 11.269984 7.295239e-02 2.400588e-03 1.968779e-02 16 2239663 2239733 71 - 1.358 0.829 -1.924
ENSG00000167969 E003 15.227809 4.453452e-02 3.698791e-02 1.468680e-01 16 2239734 2239894 161 - 1.343 1.041 -1.073
ENSG00000167969 E004 27.323952 1.219116e-01 7.052114e-02 2.257579e-01 16 2239895 2239912 18 - 1.620 1.267 -1.217
ENSG00000167969 E005 199.199344 2.574953e-04 1.074437e-06 3.026441e-05 16 2239913 2239939 27 - 2.326 2.181 -0.485
ENSG00000167969 E006 714.188796 9.518919e-05 4.697461e-07 1.466698e-05 16 2239940 2240036 97 - 2.831 2.749 -0.272
ENSG00000167969 E007 1109.204650 1.220276e-04 1.818924e-02 8.964657e-02 16 2240037 2240145 109 - 2.986 2.951 -0.116
ENSG00000167969 E008 38.033009 3.292425e-03 6.718296e-05 1.071891e-03 16 2242415 2242420 6 - 1.699 1.427 -0.931
ENSG00000167969 E009 143.087806 9.972224e-03 1.629443e-08 7.289697e-07 16 2242421 2242648 228 - 2.314 1.969 -1.153
ENSG00000167969 E010 159.889412 2.088497e-03 2.153222e-13 2.518365e-11 16 2242649 2243045 397 - 2.324 2.040 -0.949
ENSG00000167969 E011 1246.372069 9.028694e-05 6.049804e-03 3.997182e-02 16 2243046 2243168 123 - 2.985 3.014 0.099
ENSG00000167969 E012 1136.048711 1.969417e-04 1.625907e-05 3.202093e-04 16 2243169 2243224 56 - 2.923 2.977 0.181
ENSG00000167969 E013 17.226035 2.727702e-02 8.509029e-02 2.547902e-01 16 2243225 2243317 93 - 1.340 1.116 -0.790
ENSG00000167969 E014 1153.936817 9.424649e-05 3.639509e-03 2.714534e-02 16 2243318 2243368 51 - 2.948 2.981 0.110
ENSG00000167969 E015 1296.772426 2.332265e-04 1.685830e-01 3.886784e-01 16 2243369 2243439 71 - 3.013 3.026 0.042
ENSG00000167969 E016 39.558707 5.772556e-02 6.570770e-04 7.069657e-03 16 2244138 2244405 268 - 1.847 1.369 -1.630
ENSG00000167969 E017 1631.945044 8.724558e-05 7.511718e-02 2.350715e-01 16 2244406 2244552 147 - 3.114 3.128 0.049
ENSG00000167969 E018 988.921764 8.006179e-04 2.047381e-02 9.758142e-02 16 2246859 2246986 128 - 2.876 2.914 0.125
ENSG00000167969 E019 342.177654 2.173334e-04 8.847484e-07 2.553980e-05 16 2251316 2251429 114 - 2.353 2.473 0.401
ENSG00000167969 E020 51.158535 1.322708e-03 1.029643e-03 1.014073e-02 16 2251430 2251514 85 - 1.457 1.674 0.741
ENSG00000167969 E021 71.485764 1.553758e-02 6.324139e-04 6.860766e-03 16 2251515 2251627 113 - 1.542 1.817 0.932
ENSG00000167969 E022 6.157242 2.431647e-01 6.929127e-01 8.309971e-01 16 2251685 2252300 616 - 0.891 0.738 -0.600