ENSG00000167965

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397124 ENSG00000167965 HEK293_OSMI2_6hA HEK293_TMG_6hB MLST8 protein_coding protein_coding 144.0653 222.1993 63.0435 53.28468 2.803858 -1.817271 33.50794 62.28694 10.548737 17.568507 0.1313485 -2.560724 0.2169458 0.27203333 0.1681000 -0.10393333 0.01785097 0.01785097 FALSE TRUE
ENST00000565330 ENSG00000167965 HEK293_OSMI2_6hA HEK293_TMG_6hB MLST8 protein_coding retained_intron 144.0653 222.1993 63.0435 53.28468 2.803858 -1.817271 14.75129 21.24256 8.482398 3.783176 0.8669624 -1.323393 0.1149167 0.09996667 0.1363000 0.03633333 0.65726487 0.01785097 FALSE TRUE
ENST00000569417 ENSG00000167965 HEK293_OSMI2_6hA HEK293_TMG_6hB MLST8 protein_coding protein_coding 144.0653 222.1993 63.0435 53.28468 2.803858 -1.817271 61.84637 86.25600 27.495245 23.259904 3.6565656 -1.649085 0.4077542 0.37960000 0.4326667 0.05306667 0.79669155 0.01785097 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167965 E001 0.0000000       16 2204248 2204364 117 +      
ENSG00000167965 E002 0.0000000       16 2204589 2204595 7 +      
ENSG00000167965 E003 0.0000000       16 2204596 2204646 51 +      
ENSG00000167965 E004 0.0000000       16 2204647 2204682 36 +      
ENSG00000167965 E005 0.0000000       16 2204683 2204740 58 +      
ENSG00000167965 E006 0.0000000       16 2204741 2204858 118 +      
ENSG00000167965 E007 0.0000000       16 2204859 2204905 47 +      
ENSG00000167965 E008 0.0000000       16 2205153 2205176 24 +      
ENSG00000167965 E009 0.1308682 3.264919e-02 1.000000e+00   16 2205177 2205203 27 + 0.001 0.062 6.960
ENSG00000167965 E010 1.0304448 2.196908e-02 1.428684e-01   16 2205204 2205224 21 + 0.479 0.209 -1.709
ENSG00000167965 E011 2.5251725 6.057937e-02 2.848416e-01 5.254014e-01 16 2205225 2205256 32 + 0.639 0.450 -0.883
ENSG00000167965 E012 6.1305237 7.259181e-03 8.938334e-01 9.486100e-01 16 2205257 2205419 163 + 0.756 0.784 0.111
ENSG00000167965 E013 20.3710534 8.303820e-03 4.992086e-02 1.794984e-01 16 2205420 2205449 30 + 1.045 1.272 0.814
ENSG00000167965 E014 24.6584986 2.064242e-03 5.545687e-03 3.744971e-02 16 2205450 2205453 4 + 1.070 1.357 1.015
ENSG00000167965 E015 24.8308730 2.313473e-03 5.123994e-03 3.526247e-02 16 2205454 2205455 2 + 1.070 1.360 1.025
ENSG00000167965 E016 26.1215789 2.209458e-03 3.151966e-02 1.318252e-01 16 2205456 2205456 1 + 1.160 1.371 0.742
ENSG00000167965 E017 36.4444118 1.177286e-03 4.687929e-02 1.722566e-01 16 2205457 2205464 8 + 1.339 1.503 0.567
ENSG00000167965 E018 119.0769262 4.689572e-04 4.160280e-01 6.405935e-01 16 2205465 2205470 6 + 1.940 1.980 0.136
ENSG00000167965 E019 146.3625602 4.025485e-04 3.662388e-01 6.009150e-01 16 2205471 2205476 6 + 2.030 2.071 0.136
ENSG00000167965 E020 167.2595072 4.409080e-04 3.399907e-01 5.779498e-01 16 2205477 2205480 4 + 2.089 2.129 0.135
ENSG00000167965 E021 178.5930646 3.512318e-04 7.738458e-01 8.810401e-01 16 2205481 2205483 3 + 2.138 2.154 0.054
ENSG00000167965 E022 201.2018132 2.943169e-04 9.109234e-01 9.576193e-01 16 2205484 2205486 3 + 2.200 2.202 0.009
ENSG00000167965 E023 234.9533853 2.731080e-04 6.640998e-01 8.124675e-01 16 2205487 2205489 3 + 2.252 2.271 0.064
ENSG00000167965 E024 238.5062220 2.688392e-04 7.500649e-01 8.668299e-01 16 2205490 2205493 4 + 2.261 2.277 0.051
ENSG00000167965 E025 280.4665789 3.125311e-04 9.784010e-01 9.909762e-01 16 2205494 2205512 19 + 2.339 2.345 0.020
ENSG00000167965 E026 20.2157226 1.767978e-03 1.640513e-01 3.827089e-01 16 2205513 2205730 218 + 1.326 1.208 -0.414
ENSG00000167965 E027 5.4167355 5.609420e-03 3.334058e-01 5.719676e-01 16 2205731 2205740 10 + 0.567 0.739 0.737
ENSG00000167965 E028 50.7112426 1.495862e-02 1.144486e-06 3.192511e-05 16 2205741 2205768 28 + 1.140 1.672 1.844
ENSG00000167965 E029 222.3821912 7.866168e-04 1.769789e-09 9.854126e-08 16 2205769 2205875 107 + 2.052 2.279 0.759
ENSG00000167965 E030 75.1480249 5.455766e-03 4.082877e-01 6.346997e-01 16 2205876 2206028 153 + 1.734 1.785 0.171
ENSG00000167965 E031 40.4204769 5.436796e-03 7.554709e-01 8.699148e-01 16 2206029 2206030 2 + 1.495 1.518 0.080
ENSG00000167965 E032 504.0748601 8.334163e-04 4.223262e-02 1.605244e-01 16 2206031 2206060 30 + 2.553 2.604 0.169
ENSG00000167965 E033 987.9324406 1.014798e-04 6.309867e-01 7.910414e-01 16 2206061 2206214 154 + 2.879 2.892 0.043
ENSG00000167965 E034 368.7883294 2.036912e-04 8.966842e-02 2.631931e-01 16 2206358 2206360 3 + 2.490 2.456 -0.113
ENSG00000167965 E035 394.3991169 1.639306e-04 2.823687e-01 5.227877e-01 16 2206361 2206364 4 + 2.507 2.489 -0.060
ENSG00000167965 E036 639.4247723 1.064178e-04 2.615628e-01 5.006410e-01 16 2206365 2206409 45 + 2.713 2.699 -0.045
ENSG00000167965 E037 89.0129051 2.077967e-02 7.379552e-02 2.323613e-01 16 2206410 2206478 69 + 1.972 1.808 -0.551
ENSG00000167965 E038 63.5440559 1.368760e-02 1.204329e-02 6.662289e-02 16 2206479 2206483 5 + 1.856 1.655 -0.681
ENSG00000167965 E039 88.3461573 6.341478e-03 4.317285e-03 3.092805e-02 16 2206484 2206496 13 + 1.976 1.804 -0.577
ENSG00000167965 E040 591.6559480 1.116155e-04 8.875977e-02 2.615103e-01 16 2206497 2206517 21 + 2.689 2.664 -0.081
ENSG00000167965 E041 697.3582990 4.476950e-04 7.350781e-02 2.317992e-01 16 2206518 2206554 37 + 2.761 2.733 -0.092
ENSG00000167965 E042 1105.7910662 9.005324e-05 1.081484e-02 6.158774e-02 16 2206555 2206659 105 + 2.962 2.934 -0.092
ENSG00000167965 E043 7.9359808 1.742266e-01 3.937380e-02 1.531616e-01 16 2206660 2206742 83 + 1.178 0.730 -1.685
ENSG00000167965 E044 21.7134442 8.853619e-02 7.185064e-02 2.285084e-01 16 2206743 2206929 187 + 1.483 1.178 -1.064
ENSG00000167965 E045 878.2594204 1.527415e-04 5.895425e-01 7.634136e-01 16 2207035 2207110 76 + 2.826 2.841 0.049
ENSG00000167965 E046 101.0386271 5.191965e-04 1.281755e-03 1.202339e-02 16 2207111 2207192 82 + 2.011 1.881 -0.436
ENSG00000167965 E047 454.9594891 9.722632e-04 5.320665e-01 7.234995e-01 16 2207193 2207196 4 + 2.533 2.554 0.072
ENSG00000167965 E048 1246.0370391 5.210119e-04 1.585118e-01 3.745455e-01 16 2207197 2207345 149 + 3.002 2.984 -0.060
ENSG00000167965 E049 15.2340063 1.260905e-01 1.562770e-02 8.046193e-02 16 2207346 2207547 202 + 1.445 0.973 -1.677
ENSG00000167965 E050 18.2247647 7.395340e-02 4.804546e-03 3.355634e-02 16 2207586 2207826 241 + 1.503 1.061 -1.554
ENSG00000167965 E051 6.6573360 9.071814e-02 1.269445e-01 3.269252e-01 16 2207827 2207856 30 + 1.016 0.717 -1.154
ENSG00000167965 E052 21.1762819 9.035409e-02 1.223446e-01 3.194976e-01 16 2207857 2208024 168 + 1.445 1.178 -0.932
ENSG00000167965 E053 12.5851766 2.316498e-01 3.128679e-01 5.532064e-01 16 2208025 2208209 185 + 1.199 0.982 -0.784
ENSG00000167965 E054 1209.6255251 1.398545e-04 2.678698e-02 1.176476e-01 16 2208210 2208334 125 + 2.996 2.973 -0.078
ENSG00000167965 E055 27.6423347 2.296080e-02 4.563730e-01 6.705543e-01 16 2208335 2208449 115 + 1.425 1.332 -0.320
ENSG00000167965 E056 1526.6495556 7.620461e-04 3.704530e-01 6.043193e-01 16 2208450 2208613 164 + 3.083 3.073 -0.033
ENSG00000167965 E057 24.2557727 1.766205e-03 6.642662e-04 7.132503e-03 16 2208614 2208758 145 + 0.989 1.354 1.307
ENSG00000167965 E058 2228.8992018 2.280007e-03 1.707209e-03 1.506721e-02 16 2208759 2209453 695 + 3.176 3.251 0.249