ENSG00000167702

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301332 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding protein_coding 16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 0.9270044 1.970791 0.0000000 0.1577050 0.0000000 -7.6299330 0.05139583 0.11810000 0.00000000 -0.11810000 1.659291e-07 1.659291e-07 FALSE TRUE
ENST00000529644 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding retained_intron 16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 2.1791198 2.927152 1.7030433 1.3246127 0.2945809 -0.7778563 0.12838750 0.13243333 0.14083333 0.00840000 9.721531e-01 1.659291e-07 TRUE FALSE
ENST00000529864 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding retained_intron 16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 2.3029003 2.070796 2.5445087 1.6131099 0.4269720 0.2959106 0.14340417 0.07260000 0.21480000 0.14220000 2.235132e-01 1.659291e-07   FALSE
ENST00000533114 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding retained_intron 16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 3.7478670 4.110400 3.5194588 1.6145905 0.2091487 -0.2233375 0.23449167 0.19320000 0.29400000 0.10080000 4.314404e-02 1.659291e-07 FALSE FALSE
ENST00000643461 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding retained_intron 16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 1.1571578 1.439138 0.5940423 0.7312593 0.1707545 -1.2624739 0.07017083 0.06126667 0.04930000 -0.01196667 9.012647e-01 1.659291e-07 FALSE TRUE
ENST00000645548 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding protein_coding 16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 0.3411313 0.000000 0.5859578 0.0000000 0.3510968 5.8971383 0.02961667 0.00000000 0.05066667 0.05066667 2.369889e-01 1.659291e-07 FALSE TRUE
MSTRG.32266.4 ENSG00000167702 HEK293_OSMI2_6hA HEK293_TMG_6hB KIFC2 protein_coding   16.31487 20.75931 11.95682 7.484149 0.5205068 -0.7954141 3.6923324 6.061953 2.4582105 1.8815944 0.4724848 -1.2986952 0.22254167 0.30290000 0.20616667 -0.09673333 4.716781e-01 1.659291e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167702 E001 0.1723744 0.0326491905 1.000000e+00   8 144466042 144466042 1 + 0.000 0.071 8.381
ENSG00000167702 E002 0.8267151 0.4099159059 3.426947e-01   8 144466043 144466074 32 + 0.000 0.298 10.857
ENSG00000167702 E003 2.0693050 0.0105535679 1.592763e-01 3.756581e-01 8 144466075 144466102 28 + 0.201 0.493 1.841
ENSG00000167702 E004 9.4606535 0.0480598996 5.965781e-01 7.680382e-01 8 144466103 144466236 134 + 0.969 0.938 -0.113
ENSG00000167702 E005 8.1350512 0.0056824817 5.484774e-01 7.352589e-01 8 144466237 144466336 100 + 0.938 0.877 -0.233
ENSG00000167702 E006 4.2044570 0.0063863927 9.372201e-01 9.708034e-01 8 144466337 144466351 15 + 0.657 0.656 -0.004
ENSG00000167702 E007 2.9326047 0.0078258554 9.798557e-01 9.917338e-01 8 144466352 144466354 3 + 0.526 0.541 0.067
ENSG00000167702 E008 8.6639820 0.0038964651 7.570025e-01 8.708546e-01 8 144466355 144466460 106 + 0.874 0.925 0.194
ENSG00000167702 E009 12.9886675 0.0048184415 1.560024e-02 8.036156e-02 8 144466461 144466518 58 + 0.800 1.121 1.203
ENSG00000167702 E010 18.5256759 0.0020621288 1.383287e-04 1.961048e-03 8 144466760 144466838 79 + 0.839 1.287 1.639
ENSG00000167702 E011 39.0900046 0.0011913861 4.905153e-01 6.943450e-01 8 144466959 144467110 152 + 1.484 1.545 0.207
ENSG00000167702 E012 40.0560013 0.0009429359 3.591774e-01 5.951931e-01 8 144467203 144467260 58 + 1.575 1.529 -0.156
ENSG00000167702 E013 65.7858120 0.0007116781 5.220901e-01 7.163811e-01 8 144467261 144467341 81 + 1.765 1.746 -0.066
ENSG00000167702 E014 1.2429203 0.0138942018 1.725957e-02   8 144467479 144467484 6 + 0.596 0.184 -2.478
ENSG00000167702 E015 118.0874959 0.0009841410 1.650227e-01 3.839782e-01 8 144467485 144467630 146 + 2.030 1.991 -0.132
ENSG00000167702 E016 1.7121199 0.0236159718 7.484051e-01 8.657321e-01 8 144467631 144467713 83 + 0.338 0.413 0.429
ENSG00000167702 E017 77.0211069 0.0007260722 2.081923e-01 4.396728e-01 8 144467714 144467779 66 + 1.849 1.804 -0.151
ENSG00000167702 E018 17.9938425 0.0165724687 4.168221e-05 7.125627e-04 8 144467780 144467858 79 + 1.482 1.088 -1.382
ENSG00000167702 E019 97.9114585 0.0005545380 2.693664e-01 5.091670e-01 8 144467859 144467987 129 + 1.867 1.928 0.206
ENSG00000167702 E020 55.3750645 0.0049461110 1.203687e-09 6.936332e-08 8 144467988 144468328 341 + 1.906 1.574 -1.125
ENSG00000167702 E021 84.1273388 0.0006963006 7.987051e-02 2.445541e-01 8 144468329 144468406 78 + 1.900 1.835 -0.218
ENSG00000167702 E022 32.2650348 0.0194046953 3.720706e-03 2.758498e-02 8 144468407 144468439 33 + 1.609 1.383 -0.774
ENSG00000167702 E023 31.6786604 0.0011605731 8.618196e-01 9.312952e-01 8 144468536 144468586 51 + 1.440 1.439 -0.004
ENSG00000167702 E024 42.9256814 0.0014640882 8.938298e-01 9.486100e-01 8 144468587 144468624 38 + 1.561 1.563 0.005
ENSG00000167702 E025 42.3902050 0.0064616324 7.976354e-01 8.949965e-01 8 144468625 144468650 26 + 1.568 1.555 -0.044
ENSG00000167702 E026 12.2345103 0.0391741082 6.831894e-02 2.213246e-01 8 144468651 144468724 74 + 1.196 0.991 -0.743
ENSG00000167702 E027 80.5876208 0.0006910223 4.459223e-01 6.626976e-01 8 144468725 144468834 110 + 1.849 1.826 -0.079
ENSG00000167702 E028 90.8868478 0.0104020814 4.328952e-01 6.534199e-01 8 144469271 144469379 109 + 1.846 1.897 0.171
ENSG00000167702 E029 0.7852767 0.0167659277 7.539610e-02   8 144469380 144469380 1 + 0.443 0.131 -2.328
ENSG00000167702 E030 82.2897347 0.0006749976 4.233569e-02 1.608046e-01 8 144469490 144469545 56 + 1.756 1.866 0.369
ENSG00000167702 E031 105.2247388 0.0049468145 7.229805e-01 8.499680e-01 8 144469546 144469647 102 + 1.961 1.945 -0.052
ENSG00000167702 E032 2.5090929 0.0102411955 3.394844e-01 5.775275e-01 8 144470582 144470677 96 + 0.597 0.442 -0.741
ENSG00000167702 E033 111.8229588 0.0052777852 7.321906e-02 2.312752e-01 8 144471942 144472046 105 + 2.032 1.957 -0.251
ENSG00000167702 E034 60.0339979 0.0215079245 2.154312e-01 4.479854e-01 8 144472138 144472162 25 + 1.783 1.682 -0.343
ENSG00000167702 E035 94.2496258 0.0017614379 5.272449e-01 7.200217e-01 8 144472163 144472259 97 + 1.913 1.899 -0.049
ENSG00000167702 E036 67.8352189 0.0014349475 7.128886e-02 2.273442e-01 8 144472361 144472484 124 + 1.678 1.787 0.372
ENSG00000167702 E037 59.9592039 0.0006895952 2.345213e-03 1.934858e-02 8 144472577 144472706 130 + 1.554 1.745 0.648
ENSG00000167702 E038 26.6016549 0.0015397042 5.030400e-03 3.479604e-02 8 144472707 144472794 88 + 1.146 1.410 0.930
ENSG00000167702 E039 43.3665253 0.0009633381 7.606686e-05 1.189603e-03 8 144472795 144473051 257 + 1.324 1.621 1.023
ENSG00000167702 E040 8.3695350 0.0036583495 1.172585e-01 3.112308e-01 8 144473052 144473131 80 + 0.710 0.943 0.911
ENSG00000167702 E041 294.2667544 0.2264366301 2.732398e-01 5.130931e-01 8 144473132 144474648 1517 + 2.255 2.426 0.570