ENSG00000167693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336868 ENSG00000167693 HEK293_OSMI2_6hA HEK293_TMG_6hB NXN protein_coding protein_coding 31.50176 45.52778 17.05335 10.09491 0.3552508 -1.416163 20.3500886 32.414065 10.953740 6.5975542 1.6048765 -1.5643250 0.67653333 0.72123333 0.64610000 -0.07513333 8.952124e-01 1.100969e-12 FALSE TRUE
ENST00000571684 ENSG00000167693 HEK293_OSMI2_6hA HEK293_TMG_6hB NXN protein_coding protein_coding 31.50176 45.52778 17.05335 10.09491 0.3552508 -1.416163 1.4678736 1.645858 1.389707 0.3706468 0.6204900 -0.2424543 0.05614583 0.03756667 0.08303333 0.04546667 8.254794e-01 1.100969e-12 FALSE TRUE
ENST00000575801 ENSG00000167693 HEK293_OSMI2_6hA HEK293_TMG_6hB NXN protein_coding protein_coding 31.50176 45.52778 17.05335 10.09491 0.3552508 -1.416163 7.6205123 9.375648 1.566256 3.2481268 1.5662557 -2.5739548 0.18332500 0.19013333 0.08826667 -0.10186667 3.187509e-01 1.100969e-12 FALSE TRUE
MSTRG.13321.3 ENSG00000167693 HEK293_OSMI2_6hA HEK293_TMG_6hB NXN protein_coding   31.50176 45.52778 17.05335 10.09491 0.3552508 -1.416163 0.6006603 0.000000 2.095049 0.0000000 0.6997564 7.7177102 0.03387917 0.00000000 0.12136667 0.12136667 1.100969e-12 1.100969e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167693 E001 0.8100271 0.0173322344 0.3727686710   17 799310 799312 3 - 0.345 0.180 -1.234
ENSG00000167693 E002 770.1260199 0.0002787629 0.0025569103 0.020702879 17 799313 800387 1075 - 2.767 2.816 0.163
ENSG00000167693 E003 228.0235134 0.0002708937 0.3504190770 0.587640902 17 800388 800480 93 - 2.297 2.273 -0.079
ENSG00000167693 E004 411.5434916 0.0001491080 0.9675935730 0.985689251 17 800481 800767 287 - 2.532 2.535 0.009
ENSG00000167693 E005 170.5834550 0.0020199575 0.5928393527 0.765534642 17 800768 800787 20 - 2.138 2.156 0.059
ENSG00000167693 E006 478.3807242 0.0002412579 0.0460967172 0.170254084 17 800788 801131 344 - 2.628 2.591 -0.124
ENSG00000167693 E007 3.2775460 0.0409239430 0.7598634110 0.872466633 17 802997 803095 99 - 0.535 0.590 0.249
ENSG00000167693 E008 255.8611827 0.0013742451 0.0695437801 0.223863321 17 803682 803806 125 - 2.372 2.318 -0.181
ENSG00000167693 E009 1.4990472 0.2041674881 0.3521569433 0.589199053 17 803807 803984 178 - 0.530 0.303 -1.240
ENSG00000167693 E010 263.4526193 0.0006021886 0.3800824738 0.612241133 17 805068 805209 142 - 2.321 2.349 0.091
ENSG00000167693 E011 174.3052014 0.0003336098 0.0902828216 0.264282753 17 805210 805247 38 - 2.118 2.177 0.195
ENSG00000167693 E012 0.7852767 0.0169554546 0.0706651113   17 805248 805248 1 - 0.450 0.128 -2.407
ENSG00000167693 E013 0.6486114 0.0196571025 0.8887340737   17 819114 819438 325 - 0.206 0.180 -0.234
ENSG00000167693 E014 251.5850384 0.0003018087 0.0741948670 0.233126016 17 819439 819545 107 - 2.282 2.334 0.173
ENSG00000167693 E015 233.1794743 0.0003358038 0.4750308706 0.683603621 17 822357 822457 101 - 2.269 2.291 0.073
ENSG00000167693 E016 120.0396619 0.0004919191 0.2489017053 0.486658772 17 823632 823645 14 - 2.032 1.990 -0.142
ENSG00000167693 E017 168.2285407 0.0002620364 0.5105324122 0.708365270 17 823646 823686 41 - 2.162 2.143 -0.064
ENSG00000167693 E018 187.8806620 0.0002918587 0.4742096088 0.682966955 17 823687 823765 79 - 2.210 2.190 -0.069
ENSG00000167693 E019 0.3336024 0.0244411696 0.9059522607   17 825566 825960 395 - 0.000 0.128 10.982
ENSG00000167693 E020 217.3561247 0.0012862374 0.0012552395 0.011829553 17 825961 826078 118 - 2.335 2.231 -0.348
ENSG00000167693 E021 0.0000000       17 863887 864014 128 -      
ENSG00000167693 E022 0.4762370 0.0217681645 0.6339821513   17 864015 864111 97 - 0.206 0.128 -0.820
ENSG00000167693 E023 0.0000000       17 896886 897014 129 -      
ENSG00000167693 E024 0.0000000       17 905153 905242 90 -      
ENSG00000167693 E025 0.3559677 0.4622123867 0.0729547021   17 907704 908034 331 - 0.351 0.000 -12.555
ENSG00000167693 E026 0.1614157 0.0345931601 0.1280112710   17 929663 929955 293 - 0.206 0.000 -12.595
ENSG00000167693 E027 0.0000000       17 929956 930431 476 -      
ENSG00000167693 E028 0.0000000       17 933345 933413 69 -      
ENSG00000167693 E029 9.9112748 0.0162239988 0.0117190368 0.065319745 17 978299 978630 332 - 1.191 0.891 -1.100
ENSG00000167693 E030 122.5247789 0.0003608477 0.0001779361 0.002424394 17 979319 979393 75 - 2.112 1.978 -0.450
ENSG00000167693 E031 154.6496212 0.0009254175 0.0176082733 0.087673785 17 979394 979639 246 - 2.040 2.129 0.300
ENSG00000167693 E032 85.8423282 0.0174601519 0.0073653507 0.046387997 17 979640 979776 137 - 1.683 1.893 0.710