ENSG00000167670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301280 ENSG00000167670 HEK293_OSMI2_6hA HEK293_TMG_6hB CHAF1A protein_coding protein_coding 60.64634 79.4456 47.4874 12.7176 0.7291896 -0.7423004 46.937719 62.736570 35.568402 9.6907470 2.505320 -0.8185349 0.78252500 0.7913333 0.74813333 -0.04320000 0.859056053 0.002652238 FALSE  
ENST00000585854 ENSG00000167670 HEK293_OSMI2_6hA HEK293_TMG_6hB CHAF1A protein_coding protein_coding 60.64634 79.4456 47.4874 12.7176 0.7291896 -0.7423004 1.982547 1.351551 3.588834 0.1900081 0.671423 1.4022788 0.03716667 0.0179000 0.07606667 0.05816667 0.002652238 0.002652238 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167670 E001 2.8264919 0.0083024653 5.600852e-02 0.193666327 19 4402637 4402639 3 + 0.293 0.648 1.838
ENSG00000167670 E002 42.9475046 0.0119257583 2.548201e-04 0.003271913 19 4402640 4402701 62 + 1.365 1.693 1.123
ENSG00000167670 E003 58.0139907 0.0058750346 1.138429e-04 0.001664641 19 4402702 4402716 15 + 1.541 1.809 0.910
ENSG00000167670 E004 145.8496372 0.0126174722 8.752297e-01 0.938844655 19 4402717 4402814 98 + 2.117 2.139 0.073
ENSG00000167670 E005 149.6283521 0.0022220890 6.886589e-02 0.222520548 19 4405912 4405962 51 + 2.186 2.125 -0.203
ENSG00000167670 E006 0.8433510 0.3933048184 2.960842e-01   19 4408878 4408902 25 + 0.391 0.158 -1.736
ENSG00000167670 E007 1084.2287456 0.0051486105 2.348032e-03 0.019364308 19 4408903 4409444 542 + 3.062 2.969 -0.310
ENSG00000167670 E008 807.5964803 0.0010483939 6.643540e-06 0.000147288 19 4409445 4409759 315 + 2.927 2.848 -0.263
ENSG00000167670 E009 7.6265162 0.1191175029 4.234553e-01 0.646218128 19 4410412 4410523 112 + 1.019 0.842 -0.667
ENSG00000167670 E010 222.8183404 0.0003217636 1.054124e-03 0.010323191 19 4418020 4418028 9 + 2.368 2.293 -0.251
ENSG00000167670 E011 330.7474611 0.0002803258 7.641115e-05 0.001194108 19 4418029 4418076 48 + 2.540 2.465 -0.251
ENSG00000167670 E012 2.3843140 0.1508248233 2.229020e-01 0.456862508 19 4418077 4418132 56 + 0.293 0.578 1.529
ENSG00000167670 E013 608.3598428 0.0024286784 3.112763e-02 0.130720030 19 4422566 4422795 230 + 2.783 2.735 -0.159
ENSG00000167670 E014 275.1140271 0.0006607529 8.456795e-01 0.922494727 19 4423335 4423395 61 + 2.400 2.415 0.050
ENSG00000167670 E015 306.9413029 0.0023788822 6.451429e-01 0.800304653 19 4423806 4423874 69 + 2.455 2.454 -0.004
ENSG00000167670 E016 538.0438794 0.0012994478 9.582287e-01 0.981023689 19 4428664 4428890 227 + 2.690 2.701 0.034
ENSG00000167670 E017 0.4756169 0.0791299505 3.151808e-01   19 4429038 4429437 400 + 0.000 0.217 10.551
ENSG00000167670 E018 573.8151982 0.0258254238 1.852976e-01 0.410946740 19 4429438 4429606 169 + 2.661 2.749 0.292
ENSG00000167670 E019 239.3633771 1.2997967413 5.239063e-01 0.717753959 19 4429708 4429710 3 + 2.259 2.378 0.397
ENSG00000167670 E020 470.8422396 1.5343594961 5.516218e-01 0.737442781 19 4429711 4429788 78 + 2.551 2.671 0.400
ENSG00000167670 E021 582.5513528 0.0512170484 5.508427e-01 0.736934728 19 4430549 4430641 93 + 2.707 2.740 0.111
ENSG00000167670 E022 0.3032425 0.0274424043 5.379471e-01   19 4431055 4431114 60 + 0.000 0.156 9.966
ENSG00000167670 E023 339.7115634 0.0107239144 9.710877e-01 0.987378964 19 4431952 4431954 3 + 2.495 2.498 0.011
ENSG00000167670 E024 795.7282354 0.0001005080 4.437325e-03 0.031590717 19 4431955 4432207 253 + 2.835 2.884 0.161
ENSG00000167670 E025 1021.2579323 0.0071289119 2.613860e-01 0.500443603 19 4433070 4433539 470 + 2.934 2.990 0.183
ENSG00000167670 E026 12.2335520 0.0345097184 1.557714e-01 0.370612427 19 4439921 4440021 101 + 1.202 1.018 -0.661
ENSG00000167670 E027 293.8247398 0.0042052634 1.192028e-01 0.314567695 19 4442245 4442253 9 + 2.467 2.418 -0.165
ENSG00000167670 E028 508.3204229 0.0042689649 5.976821e-01 0.768757938 19 4442254 4442341 88 + 2.651 2.679 0.094
ENSG00000167670 E029 211.0016865 0.0024901355 4.282030e-02 0.162087012 19 4442925 4442926 2 + 2.231 2.315 0.280
ENSG00000167670 E030 665.5137698 0.0011635100 1.531818e-03 0.013831235 19 4442927 4443397 471 + 2.733 2.811 0.259
ENSG00000167670 E031 18.6324912 0.2555018925 4.697525e-01 0.679877404 19 4444544 4445018 475 + 1.189 1.289 0.353