ENSG00000167615

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376514 ENSG00000167615 HEK293_OSMI2_6hA HEK293_TMG_6hB LENG8 protein_coding protein_coding 82.37861 108.3883 68.17565 24.62125 2.704147 -0.6688024 17.021395 22.560466 12.277091 7.204656 0.4345108 -0.8772928 0.1979958 0.20023333 0.1801667 -0.02006667 0.856779778 0.001346213 FALSE TRUE
ENST00000421200 ENSG00000167615 HEK293_OSMI2_6hA HEK293_TMG_6hB LENG8 protein_coding protein_coding 82.37861 108.3883 68.17565 24.62125 2.704147 -0.6688024 27.313282 36.865614 17.056663 7.900001 1.2122111 -1.1114861 0.3264292 0.34186667 0.2497667 -0.09210000 0.014162309 0.001346213 FALSE FALSE
ENST00000439657 ENSG00000167615 HEK293_OSMI2_6hA HEK293_TMG_6hB LENG8 protein_coding protein_coding 82.37861 108.3883 68.17565 24.62125 2.704147 -0.6688024 8.286231 9.194919 11.881621 2.265533 0.6052152 0.3694685 0.1081125 0.08406667 0.1741667 0.09010000 0.001346213 0.001346213 FALSE TRUE
MSTRG.17688.14 ENSG00000167615 HEK293_OSMI2_6hA HEK293_TMG_6hB LENG8 protein_coding   82.37861 108.3883 68.17565 24.62125 2.704147 -0.6688024 8.203699 10.624513 11.506489 4.127249 1.9312370 0.1149470 0.0997750 0.09270000 0.1677333 0.07503333 0.329121681 0.001346213 TRUE TRUE
MSTRG.17688.7 ENSG00000167615 HEK293_OSMI2_6hA HEK293_TMG_6hB LENG8 protein_coding   82.37861 108.3883 68.17565 24.62125 2.704147 -0.6688024 7.919605 12.797333 5.322583 1.833857 0.1190814 -1.2640636 0.1035542 0.13636667 0.0784000 -0.05796667 0.724272120 0.001346213 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167615 E001 1.832319 0.0109865387 1.316914e-02 0.07112398 19 54448492 54448738 247 + 0.000 0.535 11.598
ENSG00000167615 E002 1.345744 0.0138390203 2.739011e-01   19 54448739 54448784 46 + 0.168 0.406 1.712
ENSG00000167615 E003 1.143009 0.0143582743 3.731463e-01   19 54448785 54448787 3 + 0.168 0.366 1.488
ENSG00000167615 E004 1.821360 0.0109553897 1.112142e-01 0.30098373 19 54448788 54448886 99 + 0.168 0.506 2.226
ENSG00000167615 E005 1.971817 0.0213569029 7.494205e-01 0.86641687 19 54448887 54449189 303 + 0.383 0.475 0.489
ENSG00000167615 E006 6.144334 0.0753194987 9.112503e-01 0.95782665 19 54449190 54449198 9 + 0.848 0.827 -0.083
ENSG00000167615 E007 29.827524 0.1879362479 9.628047e-01 0.98337572 19 54449199 54449215 17 + 1.515 1.431 -0.287
ENSG00000167615 E008 35.144522 0.2447363575 8.514589e-01 0.92586120 19 54449216 54449216 1 + 1.580 1.501 -0.268
ENSG00000167615 E009 81.851206 0.4972854188 6.511228e-01 0.80428921 19 54449217 54449223 7 + 1.913 1.874 -0.130
ENSG00000167615 E010 103.694461 0.5308036356 5.086385e-01 0.70690237 19 54449224 54449227 4 + 1.957 2.001 0.147
ENSG00000167615 E011 233.049118 1.0545483551 5.503250e-01 0.73654388 19 54449228 54449306 79 + 2.292 2.356 0.215
ENSG00000167615 E012 71.870677 0.3858582739 4.528525e-01 0.66779546 19 54449307 54449310 4 + 1.778 1.853 0.252
ENSG00000167615 E013 7.306141 0.0044511995 5.851431e-03 0.03901176 19 54449612 54449744 133 + 0.526 0.983 1.870
ENSG00000167615 E014 288.562633 0.0001836656 9.714323e-05 0.00145928 19 54451290 54451382 93 + 2.454 2.422 -0.108
ENSG00000167615 E015 2.059154 0.0105709447 8.952703e-01 0.94936964 19 54451992 54452092 101 + 0.461 0.475 0.072
ENSG00000167615 E016 406.988988 0.0255798999 5.618626e-02 0.19406361 19 54452093 54452267 175 + 2.619 2.559 -0.200
ENSG00000167615 E017 273.432027 0.0787645545 1.113340e-01 0.30120794 19 54452651 54452752 102 + 2.488 2.363 -0.416
ENSG00000167615 E018 193.210475 0.0924487619 1.460614e-01 0.35645948 19 54453546 54453656 111 + 2.335 2.214 -0.403
ENSG00000167615 E019 500.189772 0.0989147159 3.777774e-01 0.61036915 19 54454430 54454682 253 + 2.693 2.655 -0.124
ENSG00000167615 E020 465.548721 0.0876138326 2.314319e-01 0.46679169 19 54454951 54455092 142 + 2.687 2.611 -0.251
ENSG00000167615 E021 493.045874 0.0814641504 1.944015e-01 0.42261855 19 54455364 54455567 204 + 2.715 2.634 -0.269
ENSG00000167615 E022 515.616829 0.1062370566 3.340376e-01 0.57260083 19 54455967 54456245 279 + 2.718 2.663 -0.185
ENSG00000167615 E023 414.836724 0.1190925723 4.327732e-01 0.65330858 19 54456325 54456465 141 + 2.616 2.572 -0.147
ENSG00000167615 E024 563.021462 0.0870535500 5.354157e-01 0.72589157 19 54456636 54456921 286 + 2.715 2.720 0.018
ENSG00000167615 E025 404.838762 0.0171528914 7.105151e-01 0.84213993 19 54457747 54457848 102 + 2.538 2.593 0.183
ENSG00000167615 E026 350.323522 0.0137689057 2.010276e-01 0.43100248 19 54457934 54458002 69 + 2.443 2.544 0.335
ENSG00000167615 E027 476.057515 1.2774657508 4.832902e-01 0.68928627 19 54458103 54458232 130 + 2.546 2.685 0.465
ENSG00000167615 E028 448.160780 1.2518098050 4.756668e-01 0.68397195 19 54458314 54458414 101 + 2.516 2.660 0.478
ENSG00000167615 E029 434.120388 1.2239728230 4.431665e-01 0.66085827 19 54458415 54458521 107 + 2.484 2.652 0.562
ENSG00000167615 E030 155.848452 0.8866710065 5.633382e-01 0.74562786 19 54458522 54458567 46 + 2.092 2.192 0.335
ENSG00000167615 E031 959.134953 1.5600550727 6.117014e-01 0.77801809 19 54458568 54459352 785 + 2.872 2.981 0.364
ENSG00000167615 E032 142.202021 0.8550400484 5.616479e-01 0.74442854 19 54459353 54459408 56 + 2.068 2.147 0.265
ENSG00000167615 E033 137.483143 0.3953476632 4.329005e-01 0.65341987 19 54459409 54459464 56 + 1.991 2.154 0.544
ENSG00000167615 E034 90.131947 0.2851253835 4.643893e-01 0.67614638 19 54459465 54459481 17 + 1.873 1.951 0.264
ENSG00000167615 E035 143.772202 0.4251395615 4.580479e-01 0.67178844 19 54459482 54459537 56 + 2.084 2.147 0.212
ENSG00000167615 E036 132.277200 0.4278855120 5.968885e-01 0.76823982 19 54459538 54459576 39 + 2.080 2.099 0.064
ENSG00000167615 E037 189.752069 0.9818587687 5.810901e-01 0.75787751 19 54459577 54459632 56 + 2.212 2.263 0.170
ENSG00000167615 E038 175.709433 0.9737841689 6.339567e-01 0.79295600 19 54459633 54459649 17 + 2.197 2.223 0.085
ENSG00000167615 E039 1022.484077 1.5484199909 5.519667e-01 0.73767135 19 54459650 54460543 894 + 2.861 3.022 0.534
ENSG00000167615 E040 97.132427 0.3454682665 1.660817e-01 0.38527635 19 54460544 54460765 222 + 1.734 2.034 1.009
ENSG00000167615 E041 544.828460 1.2223987609 3.187597e-01 0.55854239 19 54460766 54461225 460 + 2.476 2.779 1.008
ENSG00000167615 E042 428.344434 1.1009747406 2.775204e-01 0.51758917 19 54461226 54461551 326 + 2.347 2.680 1.109
ENSG00000167615 E043 326.241851 1.0556016219 3.503684e-01 0.58758435 19 54461552 54461692 141 + 2.294 2.547 0.843
ENSG00000167615 E044 227.935717 0.9249690114 3.515967e-01 0.58870891 19 54461693 54461802 110 + 2.154 2.388 0.781
ENSG00000167615 E045 160.091875 0.8024029842 3.508894e-01 0.58808535 19 54461803 54463949 2147 + 2.030 2.228 0.661