ENSG00000167528

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301042 ENSG00000167528 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF641 protein_coding protein_coding 4.429701 3.534408 4.522156 0.332274 0.3549605 0.3546528 1.8739394 0.9677430 2.3623994 0.08113241 0.2222579 1.2788197 0.41887917 0.27676667 0.52126667 0.24450000 0.002420966 0.002420966 FALSE TRUE
ENST00000547026 ENSG00000167528 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF641 protein_coding protein_coding 4.429701 3.534408 4.522156 0.332274 0.3549605 0.3546528 1.4177086 1.6014708 0.8828535 0.21626628 0.1612778 -0.8518827 0.33641667 0.44993333 0.19813333 -0.25180000 0.025750901 0.002420966 FALSE TRUE
ENST00000549512 ENSG00000167528 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF641 protein_coding retained_intron 4.429701 3.534408 4.522156 0.332274 0.3549605 0.3546528 0.3621602 0.3227914 0.1768870 0.21690956 0.1768870 -0.8324520 0.07568333 0.08616667 0.03383333 -0.05233333 0.752261856 0.002420966 FALSE FALSE
MSTRG.7192.5 ENSG00000167528 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF641 protein_coding   4.429701 3.534408 4.522156 0.332274 0.3549605 0.3546528 0.3818387 0.2807439 0.7742939 0.14059740 0.1663860 1.4316454 0.08748750 0.08683333 0.17233333 0.08550000 0.730944562 0.002420966 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167528 E001 77.9219559 0.196322938 0.01268261 0.06918055 12 48337180 48340007 2828 - 1.592 2.061 1.581
ENSG00000167528 E002 183.1291686 1.063111995 0.50400631 0.70359694 12 48340008 48342420 2413 - 2.196 2.319 0.410
ENSG00000167528 E003 80.8306356 0.440832114 0.46472823 0.67637758 12 48342421 48343445 1025 - 1.860 1.955 0.321
ENSG00000167528 E004 10.9152166 0.081476254 0.53663582 0.72678564 12 48343446 48343460 15 - 1.098 1.051 -0.172
ENSG00000167528 E005 20.7183121 0.002587793 0.79879193 0.89560673 12 48343461 48343633 173 - 1.287 1.381 0.330
ENSG00000167528 E006 16.4221062 0.002669872 0.58359389 0.75934097 12 48343634 48343727 94 - 1.231 1.259 0.098
ENSG00000167528 E007 1.4576584 0.356205875 0.74444755 0.86333588 12 48344421 48344598 178 - 0.374 0.404 0.168
ENSG00000167528 E008 17.0321283 0.002235523 0.14149350 0.34971912 12 48344599 48344650 52 - 1.279 1.236 -0.153
ENSG00000167528 E009 19.1395819 0.016833688 0.18954864 0.41636661 12 48344651 48344712 62 - 1.320 1.290 -0.103
ENSG00000167528 E010 2.8463497 0.591689366 0.72417005 0.85065387 12 48344713 48344773 61 - 0.561 0.611 0.225
ENSG00000167528 E011 12.5993466 0.082702334 0.18529784 0.41094674 12 48345345 48345382 38 - 1.156 1.106 -0.178
ENSG00000167528 E012 13.5762112 0.081633426 0.19349197 0.42146331 12 48345383 48345427 45 - 1.185 1.137 -0.172
ENSG00000167528 E013 13.1681724 0.240290587 0.20539211 0.43634743 12 48345428 48345474 47 - 1.220 1.072 -0.529
ENSG00000167528 E014 3.5776702 0.007805224 0.30815830 0.54877014 12 48347149 48347251 103 - 0.700 0.615 -0.364
ENSG00000167528 E015 13.6998248 0.111572679 0.22137878 0.45513128 12 48347252 48347296 45 - 1.195 1.140 -0.197
ENSG00000167528 E016 13.6362795 0.134085618 0.28467126 0.52521509 12 48347297 48347343 47 - 1.191 1.141 -0.179
ENSG00000167528 E017 26.4994425 0.160176178 0.27519441 0.51521741 12 48347907 48348115 209 - 1.456 1.421 -0.121
ENSG00000167528 E018 0.8571428 0.017267182 0.46146579   12 48350046 48350118 73 - 0.302 0.210 -0.686
ENSG00000167528 E019 0.7970432 0.017267182 0.09858995   12 48350119 48350218 100 - 0.369 0.118 -2.102
ENSG00000167528 E020 0.5283420 1.085713630 0.60219875   12 48350219 48350771 553 - 0.231 0.120 -1.143
ENSG00000167528 E021 8.9352201 0.122852847 0.12673681 0.32660817 12 48350786 48350919 134 - 1.056 0.923 -0.491
ENSG00000167528 E022 0.0000000       12 48351208 48351414 207 -