ENSG00000167523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457689 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding nonsense_mediated_decay 17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 3.0715320 3.901559 1.0177815 1.3016258 0.2240880 -1.9282102 0.16746250 0.16203333 0.10280000 -0.05923333 7.539298e-01 7.007417e-05 FALSE TRUE
ENST00000565890 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding nonsense_mediated_decay 17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 1.8763445 3.174244 0.9798648 0.7981707 0.1502673 -1.6856473 0.10613750 0.13573333 0.09966667 -0.03606667 7.272984e-01 7.007417e-05   FALSE
ENST00000568929 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding protein_coding 17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 2.8729138 3.545315 2.3374945 0.1304107 0.1295188 -0.5988555 0.17632917 0.16436667 0.24100000 0.07663333 4.776368e-01 7.007417e-05   FALSE
ENST00000611218 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding protein_coding 17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 1.6842447 2.035595 1.4901691 0.2673532 0.1948250 -0.4473955 0.11032083 0.09656667 0.15160000 0.05503333 5.653926e-01 7.007417e-05 FALSE FALSE
MSTRG.13280.10 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding   17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 1.4050798 2.271366 0.2187797 0.7571254 0.2187797 -3.3178666 0.06897083 0.09590000 0.02450000 -0.07140000 3.081538e-01 7.007417e-05 TRUE TRUE
MSTRG.13280.24 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding   17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 1.7286377 2.585904 0.6510465 0.2469510 0.3445541 -1.9734133 0.10068333 0.12333333 0.06406667 -0.05926667 7.543210e-01 7.007417e-05   FALSE
MSTRG.13280.27 ENSG00000167523 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA33 protein_coding   17.25249 22.50796 9.754834 3.119709 0.414448 -1.205409 0.7861007 1.990110 0.0000000 0.8965621 0.0000000 -7.6439356 0.03421250 0.08140000 0.00000000 -0.08140000 7.007417e-05 7.007417e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167523 E001 0.0000000       16 89657740 89657773 34 +      
ENSG00000167523 E002 0.1723744 0.0514725900 1.000000000   16 89657774 89657777 4 + 0.001 0.070 6.961
ENSG00000167523 E003 0.1723744 0.0514725900 1.000000000   16 89657778 89657779 2 + 0.000 0.070 9.393
ENSG00000167523 E004 1.0952964 0.0153787590 0.055768572   16 89657780 89657801 22 + 0.528 0.183 -2.176
ENSG00000167523 E005 5.6479601 0.0049633780 0.290858697 0.53146650 16 89657802 89657828 27 + 0.877 0.730 -0.580
ENSG00000167523 E006 8.6899482 0.0035263616 0.174019431 0.39590202 16 89657829 89657835 7 + 1.045 0.883 -0.604
ENSG00000167523 E007 4.7103753 0.0055276373 0.557124747 0.74122565 16 89657836 89657837 2 + 0.760 0.670 -0.370
ENSG00000167523 E008 10.7103884 0.0029292488 0.990349007 0.99690197 16 89657838 89657860 23 + 0.996 0.997 0.002
ENSG00000167523 E009 11.7830616 0.0029400141 0.694207045 0.83182804 16 89657861 89657866 6 + 0.996 1.041 0.163
ENSG00000167523 E010 11.9139298 0.0028457553 0.650832611 0.80408528 16 89657867 89657870 4 + 0.996 1.048 0.188
ENSG00000167523 E011 16.5771894 0.0022396486 0.768646198 0.87779192 16 89657871 89657948 78 + 1.148 1.176 0.100
ENSG00000167523 E012 4.6664686 0.0090292895 0.856226580 0.92837632 16 89657949 89658046 98 + 0.713 0.686 -0.112
ENSG00000167523 E013 5.2793031 0.0937317483 0.984833929 0.99423868 16 89658047 89658049 3 + 0.711 0.749 0.155
ENSG00000167523 E014 61.0397768 0.0007444744 0.121392120 0.31807103 16 89658050 89658101 52 + 1.653 1.737 0.284
ENSG00000167523 E015 110.8653272 0.0005496586 0.162534647 0.38052996 16 89658102 89658209 108 + 1.928 1.983 0.185
ENSG00000167523 E016 26.0242662 0.0834223898 0.149994117 0.36231983 16 89658210 89658247 38 + 1.497 1.306 -0.662
ENSG00000167523 E017 80.1441524 0.0008489185 0.023645463 0.10799988 16 89658248 89658421 174 + 1.913 1.813 -0.337
ENSG00000167523 E018 5.8796598 0.0712700585 0.007694133 0.04791144 16 89658422 89658577 156 + 1.066 0.623 -1.735
ENSG00000167523 E019 38.1335806 0.1373386264 0.009723600 0.05692144 16 89658578 89660539 1962 + 1.805 1.378 -1.458
ENSG00000167523 E020 55.5098107 0.1073520930 0.057911228 0.19809968 16 89660540 89660827 288 + 1.875 1.593 -0.956
ENSG00000167523 E021 66.2110680 0.0748885488 0.017853243 0.08854960 16 89660828 89661111 284 + 1.955 1.666 -0.976
ENSG00000167523 E022 42.8810951 0.0842234372 0.087412158 0.25900529 16 89661112 89661300 189 + 1.728 1.503 -0.766
ENSG00000167523 E023 13.5986089 0.1019050139 0.052280926 0.18501894 16 89661301 89661327 27 + 1.323 0.993 -1.182
ENSG00000167523 E024 16.8653182 0.0733580830 0.005703508 0.03825684 16 89661328 89661412 85 + 1.443 1.051 -1.383
ENSG00000167523 E025 11.3009117 0.0208463271 0.001116138 0.01079173 16 89661413 89661508 96 + 1.275 0.888 -1.404
ENSG00000167523 E026 1.1831104 0.2476365417 0.342846335   16 89667993 89668044 52 + 0.443 0.236 -1.296
ENSG00000167523 E027 7.1057021 0.0747476428 0.589977739 0.76372679 16 89668171 89668382 212 + 0.911 0.805 -0.411
ENSG00000167523 E028 195.7686353 0.8478256765 0.303659362 0.54423317 16 89669286 89669603 318 + 2.051 2.253 0.675
ENSG00000167523 E029 65.2807890 0.2295590625 0.179916793 0.40388265 16 89669604 89669731 128 + 1.590 1.780 0.642
ENSG00000167523 E030 28.7114655 0.1030918714 0.414376759 0.63936168 16 89669732 89669741 10 + 1.317 1.419 0.352
ENSG00000167523 E031 42.5655473 0.1274859055 0.278203886 0.51832035 16 89669742 89669794 53 + 1.466 1.587 0.413
ENSG00000167523 E032 26.0607485 0.0192941941 0.617753641 0.78226917 16 89669795 89669804 10 + 1.334 1.365 0.106
ENSG00000167523 E033 34.7250417 0.0888648398 0.395416679 0.62467125 16 89669805 89669858 54 + 1.421 1.493 0.250
ENSG00000167523 E034 32.2451592 0.1091941421 0.238350115 0.47474058 16 89669859 89669922 64 + 1.313 1.480 0.580
ENSG00000167523 E035 19.4476703 0.0938247227 0.451670136 0.66687513 16 89669923 89669932 10 + 1.141 1.265 0.441
ENSG00000167523 E036 34.9952606 0.0148726619 0.028886425 0.12403801 16 89669933 89669982 50 + 1.324 1.524 0.692
ENSG00000167523 E037 38.1309643 0.0167579535 0.013427130 0.07210431 16 89669983 89670035 53 + 1.335 1.564 0.789
ENSG00000167523 E038 27.6595274 0.0119021928 0.010492645 0.06022632 16 89670036 89670045 10 + 1.183 1.435 0.884
ENSG00000167523 E039 42.0584589 0.0217230664 0.004562026 0.03227264 16 89670046 89670109 64 + 1.335 1.612 0.953
ENSG00000167523 E040 58.4288914 0.1937181190 0.172128416 0.39338641 16 89670110 89670298 189 + 1.545 1.733 0.640
ENSG00000167523 E041 107.7230399 0.5162653023 0.436983452 0.65645122 16 89670299 89671272 974 + 1.930 1.966 0.122