ENSG00000167513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301019 ENSG00000167513 HEK293_OSMI2_6hA HEK293_TMG_6hB CDT1 protein_coding protein_coding 95.39651 174.4771 52.01564 44.06723 1.789372 -1.745826 74.063373 129.49529 40.908612 33.654083 1.070035 -1.662182 0.77632500 0.7395333 0.7869333 0.0474 4.246883e-01 8.521109e-11 FALSE TRUE
ENST00000562747 ENSG00000167513 HEK293_OSMI2_6hA HEK293_TMG_6hB CDT1 protein_coding retained_intron 95.39651 174.4771 52.01564 44.06723 1.789372 -1.745826 12.036253 28.45254 8.487211 4.552725 1.114975 -1.744003 0.14445833 0.1774667 0.1628667 -0.0146 9.659486e-01 8.521109e-11 FALSE FALSE
ENST00000569140 ENSG00000167513 HEK293_OSMI2_6hA HEK293_TMG_6hB CDT1 protein_coding protein_coding 95.39651 174.4771 52.01564 44.06723 1.789372 -1.745826 4.141115 16.27932 0.000000 6.743639 0.000000 -10.669711 0.03482917 0.0818000 0.0000000 -0.0818 8.521109e-11 8.521109e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167513 E001 30.96950 9.283858e-03 2.712311e-02 1.186565e-01 16 88803789 88803824 36 + 1.246 1.459 0.741
ENSG00000167513 E002 47.17906 3.768710e-03 2.044581e-04 2.724125e-03 16 88803825 88803875 51 + 1.357 1.644 0.988
ENSG00000167513 E003 277.23781 7.361808e-04 1.276699e-03 1.198656e-02 16 88803876 88804059 184 + 2.276 2.373 0.322
ENSG00000167513 E004 406.39217 6.825683e-04 3.163989e-01 5.564258e-01 16 88804545 88804610 66 + 2.540 2.514 -0.088
ENSG00000167513 E005 534.53419 1.587214e-03 6.043347e-01 7.731302e-01 16 88804611 88804667 57 + 2.631 2.636 0.018
ENSG00000167513 E006 884.22960 1.121021e-04 1.470761e-01 3.581277e-01 16 88804762 88804898 137 + 2.841 2.861 0.067
ENSG00000167513 E007 1244.59634 1.490603e-04 2.899321e-01 5.305212e-01 16 88805440 88805633 194 + 2.995 3.005 0.034
ENSG00000167513 E008 552.26462 1.327475e-04 7.670131e-01 8.768159e-01 16 88805634 88805637 4 + 2.658 2.650 -0.024
ENSG00000167513 E009 773.38697 2.648736e-04 8.571920e-01 9.289251e-01 16 88805724 88805767 44 + 2.798 2.796 -0.004
ENSG00000167513 E010 1026.30993 3.337928e-04 7.065590e-01 8.396717e-01 16 88805768 88805869 102 + 2.918 2.919 0.003
ENSG00000167513 E011 473.42585 1.359169e-04 4.226419e-01 6.456267e-01 16 88806021 88806022 2 + 2.600 2.583 -0.058
ENSG00000167513 E012 919.90066 3.234768e-04 8.019904e-01 8.975171e-01 16 88806023 88806121 99 + 2.877 2.871 -0.020
ENSG00000167513 E013 18.70137 1.481204e-01 1.593430e-02 8.155302e-02 16 88806122 88806217 96 + 1.547 1.045 -1.763
ENSG00000167513 E014 1074.49971 1.062011e-03 3.397819e-01 5.777963e-01 16 88806486 88806638 153 + 2.924 2.940 0.055
ENSG00000167513 E015 571.30075 1.728421e-04 4.100952e-02 1.573369e-01 16 88806639 88806674 36 + 2.639 2.676 0.124
ENSG00000167513 E016 1089.79021 7.653965e-05 2.618384e-02 1.158728e-01 16 88807051 88807203 153 + 2.925 2.953 0.093
ENSG00000167513 E017 1350.81932 9.062006e-05 7.075758e-01 8.402923e-01 16 88807281 88807482 202 + 3.039 3.041 0.006
ENSG00000167513 E018 2324.12206 3.393933e-04 1.720566e-07 6.037017e-06 16 88808115 88809258 1144 + 3.324 3.258 -0.220