ENSG00000167491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000417582 ENSG00000167491 HEK293_OSMI2_6hA HEK293_TMG_6hB GATAD2A protein_coding protein_coding 60.92187 88.9996 43.80049 13.19959 2.177602 -1.022685 14.428634 18.654349 17.96193204 2.272221 1.50891333 -0.05453971 0.26468750 0.2152000 0.408666667 0.19346667 0.004814941 0.002809995 FALSE FALSE
ENST00000683918 ENSG00000167491 HEK293_OSMI2_6hA HEK293_TMG_6hB GATAD2A protein_coding protein_coding 60.92187 88.9996 43.80049 13.19959 2.177602 -1.022685 9.344923 13.949168 5.08644461 1.973321 0.33064108 -1.45364992 0.15362500 0.1571333 0.115933333 -0.04120000 0.096670592 0.002809995 FALSE TRUE
MSTRG.16764.12 ENSG00000167491 HEK293_OSMI2_6hA HEK293_TMG_6hB GATAD2A protein_coding   60.92187 88.9996 43.80049 13.19959 2.177602 -1.022685 5.502199 10.547422 3.02118850 1.398423 1.50050266 -1.80030216 0.08873750 0.1195000 0.072066667 -0.04743333 0.725233799 0.002809995 FALSE TRUE
MSTRG.16764.22 ENSG00000167491 HEK293_OSMI2_6hA HEK293_TMG_6hB GATAD2A protein_coding   60.92187 88.9996 43.80049 13.19959 2.177602 -1.022685 11.876021 12.964561 7.45028663 4.985057 2.29907713 -0.79838279 0.18139583 0.1447333 0.170033333 0.02530000 0.953780847 0.002809995 FALSE TRUE
MSTRG.16764.4 ENSG00000167491 HEK293_OSMI2_6hA HEK293_TMG_6hB GATAD2A protein_coding   60.92187 88.9996 43.80049 13.19959 2.177602 -1.022685 4.638417 5.176453 0.09810354 2.460233 0.09810354 -5.58426269 0.07023333 0.0546000 0.002133333 -0.05246667 0.031997719 0.002809995 FALSE TRUE
MSTRG.16764.6 ENSG00000167491 HEK293_OSMI2_6hA HEK293_TMG_6hB GATAD2A protein_coding   60.92187 88.9996 43.80049 13.19959 2.177602 -1.022685 6.670780 14.049944 5.07356935 3.800679 2.18008859 -1.46767714 0.10598750 0.1552000 0.115233333 -0.03996667 0.807701520 0.002809995 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167491 E001 1.1657345 0.1903947446 5.668653e-01   19 19385826 19385832 7 + 0.194 0.326 0.983
ENSG00000167491 E002 1.5886988 0.0118284724 2.644595e-01 5.036876e-01 19 19385833 19385916 84 + 0.195 0.423 1.537
ENSG00000167491 E003 0.7980729 0.0184337359 2.097435e-01   19 19385917 19385931 15 + 0.000 0.282 11.281
ENSG00000167491 E004 4.6837538 0.0121288253 2.474979e-03 2.016255e-02 19 19385932 19385970 39 + 0.195 0.798 3.216
ENSG00000167491 E005 6.6058828 0.0145894763 7.165463e-02 2.281414e-01 19 19385971 19385993 23 + 0.585 0.888 1.240
ENSG00000167491 E006 10.1956662 0.0586932312 1.893111e-01 4.161193e-01 19 19385994 19386022 29 + 0.789 1.044 0.967
ENSG00000167491 E007 50.6815432 0.0012893787 9.412032e-01 9.728350e-01 19 19386023 19386138 116 + 1.640 1.655 0.054
ENSG00000167491 E008 2.9456613 0.0076649770 8.682909e-01 9.350398e-01 19 19405675 19405791 117 + 0.515 0.552 0.174
ENSG00000167491 E009 2.8147931 0.0081185795 9.696331e-01 9.866437e-01 19 19405792 19405804 13 + 0.515 0.529 0.067
ENSG00000167491 E010 3.0765294 0.0073937205 7.731375e-01 8.805523e-01 19 19405805 19405820 16 + 0.515 0.574 0.272
ENSG00000167491 E011 2.7732869 0.0079204421 9.738136e-01 9.887904e-01 19 19405821 19405837 17 + 0.515 0.529 0.066
ENSG00000167491 E012 2.1196862 0.0102171765 9.496484e-01 9.768800e-01 19 19405838 19405855 18 + 0.432 0.452 0.103
ENSG00000167491 E013 88.0385454 0.0004509365 7.091016e-01 8.411924e-01 19 19405856 19406019 164 + 1.861 1.889 0.093
ENSG00000167491 E014 0.0000000       19 19427516 19427526 11 +      
ENSG00000167491 E015 0.1723744 0.0439405162 1.000000e+00   19 19427527 19427557 31 + 0.000 0.073 8.617
ENSG00000167491 E016 0.0000000       19 19427558 19427661 104 +      
ENSG00000167491 E017 14.4202647 0.0022684987 5.420543e-01 7.305353e-01 19 19427696 19427992 297 + 1.072 1.146 0.267
ENSG00000167491 E018 25.4775041 0.0016435094 5.054883e-01 7.046231e-01 19 19436131 19436219 89 + 1.385 1.344 -0.145
ENSG00000167491 E019 4.0063461 0.0065329045 1.478410e-01 3.592133e-01 19 19457112 19457229 118 + 0.786 0.574 -0.894
ENSG00000167491 E020 0.1614157 0.0339094368 1.444722e-01   19 19458466 19458614 149 + 0.195 0.000 -11.015
ENSG00000167491 E021 1.6951470 0.3703780742 1.285144e-01 3.295139e-01 19 19464682 19464965 284 + 0.637 0.303 -1.729
ENSG00000167491 E022 99.6887953 0.0005193830 3.608799e-01 5.963560e-01 19 19465340 19465344 5 + 1.952 1.925 -0.091
ENSG00000167491 E023 694.8340565 0.0003487883 8.530560e-08 3.222165e-06 19 19465345 19465614 270 + 2.833 2.753 -0.268
ENSG00000167491 E024 0.7088986 0.1307366200 1.000000e+00   19 19472410 19472715 306 + 0.196 0.193 -0.027
ENSG00000167491 E025 629.9018637 0.0009673535 1.657657e-05 3.255936e-04 19 19492306 19492438 133 + 2.791 2.709 -0.273
ENSG00000167491 E026 626.6049183 0.0006522978 5.937688e-07 1.803857e-05 19 19492581 19492712 132 + 2.793 2.705 -0.291
ENSG00000167491 E027 447.5396843 0.0001840910 3.396112e-04 4.135211e-03 19 19494294 19494383 90 + 2.626 2.567 -0.197
ENSG00000167491 E028 570.5156635 0.0003637230 1.854971e-02 9.089296e-02 19 19495754 19495885 132 + 2.715 2.681 -0.113
ENSG00000167491 E029 648.4856592 0.0004442001 9.438793e-01 9.743037e-01 19 19496052 19496219 168 + 2.738 2.748 0.031
ENSG00000167491 E030 829.9844275 0.0007955072 5.477444e-01 7.346765e-01 19 19498443 19498722 280 + 2.835 2.857 0.072
ENSG00000167491 E031 267.4145718 0.0002288126 5.883945e-01 7.626149e-01 19 19501118 19501120 3 + 2.341 2.366 0.083
ENSG00000167491 E032 837.4107463 0.0003085085 2.784748e-01 5.185727e-01 19 19501121 19501416 296 + 2.834 2.863 0.096
ENSG00000167491 E033 408.1402413 0.0001753268 1.211670e-02 6.692114e-02 19 19501969 19502043 75 + 2.495 2.560 0.216
ENSG00000167491 E034 658.6547986 0.0014716722 8.416518e-03 5.123094e-02 19 19502331 19502526 196 + 2.693 2.768 0.251
ENSG00000167491 E035 4100.8408125 0.0005580550 2.312454e-05 4.326406e-04 19 19505344 19508932 3589 + 3.505 3.556 0.168