ENSG00000167468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354171 ENSG00000167468 HEK293_OSMI2_6hA HEK293_TMG_6hB GPX4 protein_coding protein_coding 1014.011 1583.491 522.0751 426.4898 22.98116 -1.600761 96.95359 192.03248 19.37231 63.09405 3.128693 -3.3086132 0.08900417 0.1166667 0.03776667 -0.0789 0.0012022318 0.0005653715   FALSE
ENST00000587648 ENSG00000167468 HEK293_OSMI2_6hA HEK293_TMG_6hB GPX4 protein_coding protein_coding 1014.011 1583.491 522.0751 426.4898 22.98116 -1.600761 72.78119 52.11993 93.57476 11.32726 11.886527 0.8441616 0.09922083 0.0377000 0.17840000 0.1407 0.0005653715 0.0005653715   FALSE
ENST00000611653 ENSG00000167468 HEK293_OSMI2_6hA HEK293_TMG_6hB GPX4 protein_coding protein_coding 1014.011 1583.491 522.0751 426.4898 22.98116 -1.600761 773.51375 1233.79128 374.58542 336.77516 15.671628 -1.7197049 0.73748333 0.7765000 0.71790000 -0.0586 0.2356744828 0.0005653715   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167468 E001 0.0000000       19 1103960 1103963 4 +      
ENSG00000167468 E002 0.2617363 3.467576e-02 1.000000e+00   19 1103964 1103993 30 + 0.001 0.124 7.930
ENSG00000167468 E003 6.6181699 9.604665e-02 2.711395e-01 5.111535e-01 19 1103994 1104007 14 + 0.938 0.764 -0.676
ENSG00000167468 E004 192.0561337 6.291011e-03 6.298111e-12 5.632249e-10 19 1104008 1104051 44 + 1.839 2.257 1.401
ENSG00000167468 E005 424.3414810 5.830500e-03 1.445438e-06 3.917468e-05 19 1104052 1104066 15 + 2.347 2.576 0.765
ENSG00000167468 E006 1638.8297749 7.157705e-03 2.239775e-01 4.581667e-01 19 1104067 1104072 6 + 3.078 3.133 0.184
ENSG00000167468 E007 4102.0138805 1.736580e-03 3.034292e-04 3.764007e-03 19 1104073 1104127 55 + 3.452 3.537 0.281
ENSG00000167468 E008 37.7664797 9.714151e-03 1.315548e-02 7.106547e-02 19 1104415 1104673 259 + 1.311 1.539 0.788
ENSG00000167468 E009 30.9590413 2.160679e-02 2.010906e-02 9.625631e-02 19 1104674 1104705 32 + 1.205 1.460 0.889
ENSG00000167468 E010 20.8337158 2.941450e-02 2.585929e-03 2.087812e-02 19 1104706 1104742 37 + 0.897 1.317 1.520
ENSG00000167468 E011 266.8437286 7.870874e-03 6.301821e-01 7.905083e-01 19 1104743 1104929 187 + 2.318 2.343 0.083
ENSG00000167468 E012 30.1167845 7.011368e-02 2.958304e-01 5.363269e-01 19 1105152 1105155 4 + 1.534 1.361 -0.596
ENSG00000167468 E013 60.7890291 1.909271e-02 3.661277e-01 6.008708e-01 19 1105156 1105185 30 + 1.766 1.681 -0.288
ENSG00000167468 E014 6144.4827361 4.893694e-04 1.068129e-01 2.936917e-01 19 1105186 1105252 67 + 3.674 3.703 0.095
ENSG00000167468 E015 4375.7017653 3.172736e-04 1.551332e-08 6.971468e-07 19 1105253 1105274 22 + 3.588 3.541 -0.157
ENSG00000167468 E016 3888.3919137 5.038999e-05 2.283546e-12 2.209678e-10 19 1105275 1105280 6 + 3.530 3.496 -0.112
ENSG00000167468 E017 37.4678389 1.167889e-02 2.603410e-01 4.992986e-01 19 1105281 1105365 85 + 1.567 1.475 -0.316
ENSG00000167468 E018 7863.4178651 1.376543e-04 7.752267e-05 1.208475e-03 19 1105366 1105453 88 + 3.817 3.802 -0.050
ENSG00000167468 E019 7533.7935849 6.485350e-05 1.812078e-08 8.030599e-07 19 1105454 1105510 57 + 3.802 3.785 -0.057
ENSG00000167468 E020 4233.5089485 5.980814e-05 8.878828e-12 7.712681e-10 19 1105658 1105664 7 + 3.565 3.533 -0.105
ENSG00000167468 E021 7034.2171611 3.497398e-04 2.782654e-03 2.207908e-02 19 1105665 1105725 61 + 3.770 3.752 -0.062
ENSG00000167468 E022 7054.7271050 2.640453e-04 3.437215e-01 5.813820e-01 19 1105726 1105809 84 + 3.740 3.761 0.071
ENSG00000167468 E023 32.9344238 2.013571e-01 4.303513e-01 6.513569e-01 19 1105810 1106180 371 + 1.564 1.402 -0.553
ENSG00000167468 E024 32.0914713 3.078689e-02 8.625831e-01 9.317765e-01 19 1106181 1106241 61 + 1.456 1.427 -0.100
ENSG00000167468 E025 4291.0194388 7.014416e-04 5.380576e-02 1.886267e-01 19 1106242 1106266 25 + 3.507 3.549 0.140
ENSG00000167468 E026 58.4547292 1.209423e-02 7.703904e-01 8.788913e-01 19 1106378 1106399 22 + 1.704 1.685 -0.065
ENSG00000167468 E027 4940.3449230 1.180430e-03 5.055783e-02 1.809726e-01 19 1106400 1106459 60 + 3.562 3.611 0.164
ENSG00000167468 E028 69.5845744 1.428916e-01 3.741618e-01 6.074576e-01 19 1106460 1106463 4 + 1.903 1.713 -0.642
ENSG00000167468 E029 2808.0223404 7.446236e-04 1.754002e-02 8.742364e-02 19 1106540 1106546 7 + 3.315 3.368 0.177
ENSG00000167468 E030 3416.5133804 7.160948e-04 2.363986e-03 1.946846e-02 19 1106547 1106572 26 + 3.394 3.454 0.201
ENSG00000167468 E031 4479.4000948 6.904572e-04 3.404746e-03 2.578966e-02 19 1106573 1106853 281 + 3.514 3.571 0.191