ENSG00000167460

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000643579 ENSG00000167460 HEK293_OSMI2_6hA HEK293_TMG_6hB TPM4 protein_coding protein_coding 48.44913 32.91474 41.64716 6.958 1.350545 0.3393926 41.959476 27.55182 38.9463248 6.7759614 1.5950218 0.4991867 0.85837083 0.8196 0.9347333 0.1151333 0.1560193 0.0142783 FALSE  
ENST00000659595 ENSG00000167460 HEK293_OSMI2_6hA HEK293_TMG_6hB TPM4 protein_coding nonsense_mediated_decay 48.44913 32.91474 41.64716 6.958 1.350545 0.3393926 3.484253 2.47059 0.7217499 0.5083202 0.2721554 -1.7612609 0.06757083 0.0770 0.0178000 -0.0592000 0.0142783 0.0142783 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167460 E001 0.0000000       19 16067021 16067306 286 +      
ENSG00000167460 E002 0.0000000       19 16067534 16067537 4 +      
ENSG00000167460 E003 0.0000000       19 16067538 16067699 162 +      
ENSG00000167460 E004 0.0000000       19 16067700 16067732 33 +      
ENSG00000167460 E005 0.0000000       19 16067733 16067738 6 +      
ENSG00000167460 E006 0.0000000       19 16067739 16067962 224 +      
ENSG00000167460 E007 0.0000000       19 16075679 16075679 1 +      
ENSG00000167460 E008 0.0000000       19 16075680 16075709 30 +      
ENSG00000167460 E009 0.0000000       19 16075710 16075875 166 +      
ENSG00000167460 E010 0.0000000       19 16075941 16076046 106 +      
ENSG00000167460 E011 0.0000000       19 16076047 16076072 26 +      
ENSG00000167460 E012 0.0000000       19 16076073 16076090 18 +      
ENSG00000167460 E013 0.5481031 0.2752960578 6.410220e-01   19 16076091 16076172 82 + 0.117 0.228 1.151
ENSG00000167460 E014 1.3029521 0.0587051766 2.739942e-02   19 16076439 16076448 10 + 0.118 0.558 3.066
ENSG00000167460 E015 1.3029521 0.0587051766 2.739942e-02   19 16076449 16076455 7 + 0.118 0.558 3.066
ENSG00000167460 E016 13.1619285 0.0060047027 2.687833e-11 2.147017e-09 19 16076456 16076488 33 + 0.616 1.396 2.935
ENSG00000167460 E017 14.0430138 0.0045176358 1.120705e-12 1.135569e-10 19 16076489 16076494 6 + 0.616 1.425 3.032
ENSG00000167460 E018 15.7691179 0.0071632466 9.617817e-13 9.886964e-11 19 16076495 16076498 4 + 0.677 1.475 2.942
ENSG00000167460 E019 35.7445412 0.3166584770 1.460595e-02 7.661883e-02 19 16076499 16076520 22 + 1.151 1.781 2.175
ENSG00000167460 E020 51.3927306 0.5101581894 6.670361e-02 2.176666e-01 19 16076521 16076560 40 + 1.367 1.917 1.873
ENSG00000167460 E021 87.3891941 0.7496733232 1.577613e-01 3.733485e-01 19 16076561 16076644 84 + 1.660 2.123 1.558
ENSG00000167460 E022 62.6751651 0.6552825799 1.603542e-01 3.773275e-01 19 16076645 16076651 7 + 1.542 1.971 1.452
ENSG00000167460 E023 88.3231391 0.8159507811 2.556414e-01 4.943328e-01 19 16076652 16076697 46 + 1.737 2.098 1.212
ENSG00000167460 E024 0.1723744 0.0541990827 4.961534e-01   19 16077016 16077020 5 + 0.000 0.125 11.179
ENSG00000167460 E025 0.8624920 0.3532641569 2.717665e-01   19 16077021 16077130 110 + 0.117 0.377 2.156
ENSG00000167460 E026 5.0988248 0.0724733535 8.749580e-01 9.387129e-01 19 16077957 16078149 193 + 0.780 0.780 -0.001
ENSG00000167460 E027 14.1876559 0.2387125205 9.354002e-01 9.698646e-01 19 16078852 16079501 650 + 1.116 1.234 0.419
ENSG00000167460 E028 13.4818392 0.1917953992 2.395373e-01 4.761001e-01 19 16079502 16080317 816 + 0.946 1.304 1.292
ENSG00000167460 E029 5.5009894 0.2590767788 5.756786e-02 1.973186e-01 19 16080318 16080442 125 + 0.465 1.005 2.247
ENSG00000167460 E030 3.6027736 0.2610269796 1.370127e-01 3.429801e-01 19 16080443 16080551 109 + 0.411 0.825 1.847
ENSG00000167460 E031 3.0525869 0.0075699342 2.953899e-01 5.358601e-01 19 16080552 16080764 213 + 0.504 0.698 0.862
ENSG00000167460 E032 2.3859296 0.0696878225 5.065599e-01 7.053275e-01 19 16080765 16080914 150 + 0.458 0.601 0.676
ENSG00000167460 E033 4.2065499 0.2627124841 4.262426e-01 6.482175e-01 19 16080915 16081019 105 + 0.544 0.837 1.233
ENSG00000167460 E034 3.3261868 0.2333157956 2.015429e-01 4.315865e-01 19 16081020 16081075 56 + 0.410 0.773 1.651
ENSG00000167460 E035 6.0816156 0.1834936794 1.417539e-01 3.501131e-01 19 16081076 16081343 268 + 0.613 1.001 1.541
ENSG00000167460 E036 1.9813710 0.0203232229 2.763348e-01 5.163334e-01 19 16081344 16081440 97 + 0.353 0.564 1.090
ENSG00000167460 E037 0.8433510 0.3943763509 7.225246e-01   19 16081441 16081448 8 + 0.290 0.224 -0.491
ENSG00000167460 E038 1.6823100 0.3371416205 1.801398e-01 4.041840e-01 19 16081449 16081538 90 + 0.215 0.567 2.071
ENSG00000167460 E039 0.6120945 0.0210792352 3.341206e-01   19 16081539 16081543 5 + 0.118 0.300 1.666
ENSG00000167460 E040 3.0271436 0.3519814218 3.759250e-01 6.089536e-01 19 16081544 16081912 369 + 0.412 0.746 1.528
ENSG00000167460 E041 223.8072130 0.0095641092 3.703198e-01 6.042228e-01 19 16081913 16082046 134 + 2.312 2.394 0.273
ENSG00000167460 E042 0.1614157 0.0341292280 4.801358e-01   19 16086294 16086422 129 + 0.118 0.000 -12.035
ENSG00000167460 E043 281.0002694 0.0026826323 8.491856e-02 2.544620e-01 19 16086423 16086540 118 + 2.459 2.447 -0.042
ENSG00000167460 E044 183.8744182 0.0005016652 2.012584e-02 9.631491e-02 19 16088027 16088058 32 + 2.280 2.257 -0.076
ENSG00000167460 E045 216.8742807 0.0020956642 3.356741e-02 1.376728e-01 19 16088059 16088097 39 + 2.351 2.324 -0.090
ENSG00000167460 E046 0.1723744 0.0541990827 4.961534e-01   19 16088098 16088149 52 + 0.000 0.125 11.179
ENSG00000167460 E047 0.1723744 0.0541990827 4.961534e-01   19 16088150 16088259 110 + 0.000 0.125 11.179
ENSG00000167460 E048 0.3337900 0.0420872516 9.947896e-01   19 16088260 16088618 359 + 0.118 0.125 0.087
ENSG00000167460 E049 0.0000000       19 16088619 16088718 100 +      
ENSG00000167460 E050 0.6897577 0.0854774554 3.219579e-01   19 16088719 16088849 131 + 0.289 0.125 -1.505
ENSG00000167460 E051 0.8621321 0.4169100893 7.129542e-01   19 16088850 16089044 195 + 0.293 0.224 -0.509
ENSG00000167460 E052 266.8779561 0.0019317018 2.568600e-03 2.077178e-02 19 16089045 16089120 76 + 2.451 2.406 -0.151
ENSG00000167460 E053 0.4812263 0.0218057398 5.895175e-01   19 16089121 16089653 533 + 0.118 0.221 1.083
ENSG00000167460 E054 0.4397201 0.0754539010 6.217104e-01   19 16092891 16093039 149 + 0.119 0.220 1.067
ENSG00000167460 E055 0.7850890 0.0172671820 6.916200e-01   19 16093040 16093132 93 + 0.211 0.300 0.669
ENSG00000167460 E056 1.3030199 0.0138061869 9.676298e-01   19 16093133 16093535 403 + 0.353 0.367 0.088
ENSG00000167460 E057 251.4706440 0.0002377984 2.214791e-06 5.704877e-05 19 16093536 16093598 63 + 2.435 2.370 -0.215
ENSG00000167460 E058 250.0761789 0.0004341454 8.419258e-05 1.295211e-03 19 16093684 16093753 70 + 2.427 2.376 -0.167
ENSG00000167460 E059 1.9885732 0.2583838566 4.154654e-01 6.401817e-01 19 16095264 16095357 94 + 0.355 0.566 1.084
ENSG00000167460 E060 2.9978813 0.3974174435 2.723081e-01 5.122136e-01 19 16095358 16095591 234 + 0.358 0.757 1.880
ENSG00000167460 E061 0.8674813 1.0195083421 6.673434e-01   19 16095592 16095775 184 + 0.121 0.377 2.101
ENSG00000167460 E062 0.3641499 0.0301842315 9.940380e-01   19 16095776 16095893 118 + 0.118 0.125 0.089
ENSG00000167460 E063 2.6074449 0.0370766936 3.686096e-01 6.029163e-01 19 16095894 16096744 851 + 0.459 0.637 0.827
ENSG00000167460 E064 5.6635728 0.1738017100 4.614305e-02 1.703659e-01 19 16099667 16101263 1597 + 0.503 1.008 2.071
ENSG00000167460 E065 340.4154847 0.0010948674 2.471878e-03 2.014146e-02 19 16101264 16101409 146 + 2.547 2.518 -0.096
ENSG00000167460 E066 754.3998249 0.0025185767 2.518333e-02 1.127616e-01 19 16101410 16102059 650 + 2.882 2.873 -0.030
ENSG00000167460 E067 805.0342608 0.0052073848 4.800322e-01 6.870988e-01 19 16102060 16103002 943 + 2.892 2.920 0.092