ENSG00000167395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300850 ENSG00000167395 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF646 protein_coding protein_coding 9.23146 14.32176 5.664128 1.863312 1.051772 -1.336745 1.723844 2.559133 1.3304993 0.4375145 0.3891138 -0.9385110 0.1914625 0.1767000 0.29036667 0.1136667 0.89805296 0.02254006 FALSE TRUE
ENST00000394979 ENSG00000167395 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF646 protein_coding protein_coding 9.23146 14.32176 5.664128 1.863312 1.051772 -1.336745 3.790716 5.851742 1.3783683 0.7062587 0.7215991 -2.0779392 0.3833042 0.4097333 0.20453333 -0.2052000 0.69975829 0.02254006 FALSE TRUE
ENST00000428260 ENSG00000167395 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF646 protein_coding protein_coding 9.23146 14.32176 5.664128 1.863312 1.051772 -1.336745 1.118154 2.678627 0.3385633 0.2743609 0.3385633 -2.9473771 0.1156583 0.1888667 0.04903333 -0.1398333 0.28061171 0.02254006 FALSE TRUE
ENST00000564189 ENSG00000167395 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF646 protein_coding protein_coding 9.23146 14.32176 5.664128 1.863312 1.051772 -1.336745 2.564544 3.163403 2.5636488 0.4431636 0.6280456 -0.3022157 0.3061000 0.2202333 0.44790000 0.2276667 0.02254006 0.02254006 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167395 E001 2.227347 0.0119689759 0.0386692881 0.151283969 16 31074422 31074422 1 + 0.693 0.356 -1.630
ENSG00000167395 E002 12.436465 0.0030216124 0.0009237318 0.009290548 16 31074423 31074442 20 + 1.287 0.951 -1.209
ENSG00000167395 E003 40.310597 0.0010281788 0.0318123006 0.132654429 16 31074443 31074631 189 + 1.633 1.495 -0.470
ENSG00000167395 E004 18.765549 0.0018250603 1.0000000000 1.000000000 16 31074632 31074720 89 + 1.206 1.206 -0.001
ENSG00000167395 E005 10.198872 0.0031120027 0.4271804348 0.648853477 16 31074721 31074761 41 + 1.035 0.943 -0.339
ENSG00000167395 E006 22.597271 0.0019832792 0.2397871582 0.476390395 16 31075902 31076245 344 + 1.367 1.269 -0.342
ENSG00000167395 E007 1416.529818 0.0002141666 0.0011323899 0.010909733 16 31076246 31081701 5456 + 3.073 3.050 -0.075
ENSG00000167395 E008 152.450236 0.0004178529 0.0020255186 0.017227986 16 31081702 31082593 892 + 1.997 2.109 0.377
ENSG00000167395 E009 37.546752 0.0038365181 0.0069011138 0.044188517 16 31082594 31082673 80 + 1.300 1.530 0.792
ENSG00000167395 E010 61.703919 0.0008153197 0.0060711761 0.040080289 16 31082674 31082970 297 + 1.569 1.734 0.562
ENSG00000167395 E011 133.031555 0.0004500491 0.0159915873 0.081787060 16 31082971 31084196 1226 + 1.955 2.049 0.315