ENSG00000167114

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300456 ENSG00000167114 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC27A4 protein_coding protein_coding 74.47401 108.7105 47.18865 18.07035 1.593893 -1.203806 22.30147 37.89013 10.98979 4.486114 0.381396 -1.7847270 0.3037042 0.3553667 0.2332333 -0.1221333 0.019903479 0.007353324 FALSE TRUE
MSTRG.33448.9 ENSG00000167114 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC27A4 protein_coding   74.47401 108.7105 47.18865 18.07035 1.593893 -1.203806 39.66825 54.85770 30.34795 10.040849 1.110703 -0.8538826 0.5340583 0.5015333 0.6435000 0.1419667 0.007353324 0.007353324 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167114 E001 0.719380 0.0405526568 5.063233e-01   9 128340160 128340229 70 + 0.319 0.196 -0.921
ENSG00000167114 E002 3.125120 0.0079275765 5.402104e-01 7.291438e-01 9 128340513 128340517 5 + 0.501 0.609 0.495
ENSG00000167114 E003 4.863729 0.0058664248 9.953743e-01 9.992509e-01 9 128340518 128340521 4 + 0.728 0.732 0.016
ENSG00000167114 E004 5.066463 0.0054466674 9.114628e-01 9.579130e-01 9 128340522 128340522 1 + 0.728 0.747 0.078
ENSG00000167114 E005 5.530933 0.0053461138 6.886886e-01 8.282711e-01 9 128340523 128340525 3 + 0.728 0.790 0.248
ENSG00000167114 E006 6.529355 0.0054971442 8.848838e-01 9.438401e-01 9 128340526 128340526 1 + 0.844 0.828 -0.061
ENSG00000167114 E007 8.286177 0.0041967995 9.498704e-01 9.769905e-01 9 128340527 128340539 13 + 0.907 0.918 0.041
ENSG00000167114 E008 12.820641 0.1324231180 6.882800e-01 8.279898e-01 9 128340540 128340583 44 + 1.178 1.046 -0.476
ENSG00000167114 E009 11.668868 0.0108372900 7.566546e-01 8.706102e-01 9 128340584 128340617 34 + 1.075 1.045 -0.109
ENSG00000167114 E010 6.430524 0.1262414329 4.798497e-01 6.869854e-01 9 128340618 128340624 7 + 0.946 0.760 -0.721
ENSG00000167114 E011 3.604699 0.1554188288 3.303419e-01 5.692911e-01 9 128340625 128340645 21 + 0.780 0.539 -1.029
ENSG00000167114 E012 116.326908 0.0018051956 2.110771e-05 4.001077e-04 9 128340646 128340753 108 + 1.865 2.055 0.638
ENSG00000167114 E013 215.448860 0.0003527555 2.429193e-05 4.509048e-04 9 128340754 128340838 85 + 2.182 2.308 0.422
ENSG00000167114 E014 3.091927 0.1456140644 3.818740e-01 6.138112e-01 9 128341816 128341881 66 + 0.419 0.622 0.973
ENSG00000167114 E015 437.303829 0.0001689991 1.236266e-01 3.214659e-01 9 128343127 128343281 155 + 2.562 2.594 0.107
ENSG00000167114 E016 235.362492 0.0018398370 1.962551e-01 4.248716e-01 9 128343282 128343293 12 + 2.348 2.304 -0.148
ENSG00000167114 E017 1163.355434 0.0003943133 7.645216e-05 1.194529e-03 9 128345155 128345549 395 + 3.050 2.995 -0.185
ENSG00000167114 E018 609.518829 0.0011591241 4.998377e-03 3.461824e-02 9 128348545 128348703 159 + 2.776 2.712 -0.214
ENSG00000167114 E019 342.024914 0.0003826736 2.464842e-01 4.841337e-01 9 128350312 128350347 36 + 2.497 2.471 -0.086
ENSG00000167114 E020 293.175385 0.0011745438 6.405915e-02 2.117965e-01 9 128350348 128350381 34 + 2.450 2.397 -0.177
ENSG00000167114 E021 511.843391 0.0016850225 1.783227e-02 8.846747e-02 9 128350484 128350575 92 + 2.699 2.635 -0.213
ENSG00000167114 E022 705.994321 0.0019933837 2.126200e-02 1.001880e-01 9 128352638 128352747 110 + 2.837 2.775 -0.208
ENSG00000167114 E023 881.723479 0.0001005710 1.873842e-02 9.151659e-02 9 128353025 128353234 210 + 2.912 2.882 -0.100
ENSG00000167114 E024 744.256001 0.0015163822 9.879221e-01 9.958027e-01 9 128353415 128353541 127 + 2.813 2.814 0.004
ENSG00000167114 E025 730.940205 0.0012915851 8.966577e-01 9.501688e-01 9 128355053 128355177 125 + 2.809 2.805 -0.011
ENSG00000167114 E026 423.857740 0.0006455757 6.799113e-01 8.226250e-01 9 128355178 128355190 13 + 2.577 2.568 -0.033
ENSG00000167114 E027 844.079746 0.0005519601 2.591592e-01 4.980557e-01 9 128355398 128355562 165 + 2.856 2.875 0.063
ENSG00000167114 E028 739.366532 0.0008844553 5.784439e-04 6.385821e-03 9 128355650 128355796 147 + 2.759 2.829 0.234
ENSG00000167114 E029 509.570530 0.0001450160 1.724895e-06 4.581278e-05 9 128360334 128360414 81 + 2.583 2.675 0.306
ENSG00000167114 E030 2210.814235 0.0009266954 8.685904e-03 5.241326e-02 9 128360415 128361470 1056 + 3.258 3.297 0.130