ENSG00000167088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000579618 ENSG00000167088 HEK293_OSMI2_6hA HEK293_TMG_6hB SNRPD1 protein_coding protein_coding 302.2573 216.4405 315.1569 36.16961 10.46427 0.5420792 43.90215 33.64203 32.09282 5.681706 1.9758606 -0.0679934 0.1459500 0.15563333 0.1017667 -0.05386667 3.967268e-03 1.681855e-08    
ENST00000582475 ENSG00000167088 HEK293_OSMI2_6hA HEK293_TMG_6hB SNRPD1 protein_coding protein_coding 302.2573 216.4405 315.1569 36.16961 10.46427 0.5420792 30.77790 14.56220 40.45550 2.243077 0.5150622 1.4734735 0.0988375 0.06766667 0.1286333 0.06096667 1.681855e-08 1.681855e-08    
MSTRG.15546.1 ENSG00000167088 HEK293_OSMI2_6hA HEK293_TMG_6hB SNRPD1 protein_coding   302.2573 216.4405 315.1569 36.16961 10.46427 0.5420792 218.40919 163.68761 231.72346 27.575208 8.2628915 0.5014331 0.7254917 0.75573333 0.7351667 -0.02056667 6.937752e-01 1.681855e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167088 E001 0.1614157 3.391097e-02 6.166978e-01   18 21611610 21611678 69 + 0.108 0.000 -8.727
ENSG00000167088 E002 2.7731671 3.207089e-02 1.614176e-01 3.788652e-01 18 21612158 21612265 108 + 0.430 0.675 1.142
ENSG00000167088 E003 47.6160672 2.103889e-03 3.864418e-01 6.176630e-01 18 21612266 21612313 48 + 1.701 1.667 -0.116
ENSG00000167088 E004 245.5714068 2.146800e-03 6.368781e-06 1.421803e-04 18 21612314 21612330 17 + 2.444 2.312 -0.438
ENSG00000167088 E005 1722.5719745 1.261400e-03 2.454699e-02 1.108387e-01 18 21612331 21612443 113 + 3.211 3.261 0.165
ENSG00000167088 E006 2194.0797868 3.723673e-04 2.506465e-03 2.037116e-02 18 21622725 21622801 77 + 3.319 3.363 0.146
ENSG00000167088 E007 2462.5456573 5.899269e-05 1.927947e-04 2.595606e-03 18 21623748 21623870 123 + 3.371 3.411 0.134
ENSG00000167088 E008 948.7444765 7.113066e-04 3.395316e-02 1.387332e-01 18 21623871 21623874 4 + 2.952 3.000 0.161
ENSG00000167088 E009 1671.1485176 3.826380e-04 1.072875e-03 1.047722e-02 18 21623875 21623939 65 + 3.196 3.248 0.170
ENSG00000167088 E010 1524.9306237 4.943353e-04 5.600112e-02 1.936486e-01 18 21629062 21629189 128 + 3.163 3.201 0.126
ENSG00000167088 E011 868.8028963 9.244871e-05 3.417882e-99 9.673916e-95 18 21629190 21630137 948 + 3.031 2.773 -0.858
ENSG00000167088 E012 79.0300493 5.746346e-04 1.354387e-24 6.647573e-22 18 21630138 21630485 348 + 2.042 1.596 -1.505
ENSG00000167088 E013 2.0012904 1.232220e-02 1.235305e-01 3.213460e-01 18 21630486 21630618 133 + 0.581 0.324 -1.343
ENSG00000167088 E014 19.3257927 1.851361e-03 7.522354e-16 1.290373e-13 18 21630619 21631579 961 + 1.504 0.735 -2.803
ENSG00000167088 E015 54.9378108 8.813477e-04 2.998479e-27 1.936162e-24 18 21631580 21633127 1548 + 1.914 1.314 -2.049
ENSG00000167088 E016 10.5838376 4.529596e-02 7.207551e-04 7.615305e-03 18 21633128 21633524 397 + 1.213 0.705 -1.913
ENSG00000167088 E017 0.3206185 2.744240e-02 2.793519e-01   18 21636027 21636085 59 + 0.194 0.000 -9.725