ENSG00000167085

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300408 ENSG00000167085 HEK293_OSMI2_6hA HEK293_TMG_6hB PHB protein_coding protein_coding 483.9021 631.8164 315.3773 85.64364 11.74525 -1.002404 148.7605 190.95812 67.14164 37.666814 1.998741 -1.5078372 0.2945250 0.2962333 0.2134000 -0.08283333 0.231402331 0.001235838 FALSE  
ENST00000506273 ENSG00000167085 HEK293_OSMI2_6hA HEK293_TMG_6hB PHB protein_coding processed_transcript 483.9021 631.8164 315.3773 85.64364 11.74525 -1.002404 69.7269 72.98428 64.77438 8.802937 0.955212 -0.1721375 0.1567083 0.1169333 0.2057667 0.08883333 0.001235838 0.001235838 FALSE  
ENST00000512041 ENSG00000167085 HEK293_OSMI2_6hA HEK293_TMG_6hB PHB protein_coding nonsense_mediated_decay 483.9021 631.8164 315.3773 85.64364 11.74525 -1.002404 228.5764 321.83005 145.32838 45.053876 6.099203 -1.1469282 0.4641042 0.5092667 0.4607333 -0.04853333 0.500378546 0.001235838 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167085 E001 0.9232117 2.366928e-01 8.485736e-01   17 49404049 49404051 3 - 0.189 0.254 0.541
ENSG00000167085 E002 51.9792587 2.863421e-01 2.275038e-01 0.4623724445 17 49404052 49404071 20 - 1.490 1.710 0.749
ENSG00000167085 E003 173.2757000 9.670389e-01 4.044550e-01 0.6318597489 17 49404072 49404142 71 - 2.022 2.223 0.672
ENSG00000167085 E004 1514.5665461 7.481283e-01 3.322883e-01 0.5710896729 17 49404143 49404754 612 - 2.948 3.164 0.720
ENSG00000167085 E005 582.5342287 4.280282e-01 2.313682e-01 0.4666996413 17 49404755 49404857 103 - 2.527 2.751 0.745
ENSG00000167085 E006 2698.0278869 1.898052e+00 5.230619e-01 0.7171237369 17 49404858 49405042 185 - 3.212 3.412 0.665
ENSG00000167085 E007 1952.4407244 1.787964e+00 4.946866e-01 0.6972119571 17 49405043 49405067 25 - 3.056 3.275 0.729
ENSG00000167085 E008 4456.4736613 2.652102e-01 2.352676e-01 0.4711954947 17 49405068 49405204 137 - 3.453 3.625 0.570
ENSG00000167085 E009 4460.1984641 1.073944e-02 2.471330e-01 0.4848396602 17 49406759 49406854 96 - 3.536 3.604 0.228
ENSG00000167085 E010 20.3464038 3.623542e-02 1.524039e-02 0.0789878931 17 49406855 49406868 14 - 1.452 1.187 -0.927
ENSG00000167085 E011 47.2097000 9.714448e-02 3.643467e-03 0.0271653206 17 49406869 49407441 573 - 1.890 1.475 -1.411
ENSG00000167085 E012 84.2100275 1.121909e-01 5.889086e-04 0.0064815439 17 49407442 49408755 1314 - 2.193 1.668 -1.766
ENSG00000167085 E013 32.1812219 7.623230e-02 1.360712e-05 0.0002738567 17 49408756 49409041 286 - 1.822 1.210 -2.101
ENSG00000167085 E014 3126.6766461 5.769443e-05 6.161508e-01 0.7811381525 17 49409042 49409075 34 - 3.419 3.442 0.077
ENSG00000167085 E015 4304.3184645 5.026489e-03 2.340045e-01 0.4697317309 17 49409076 49409134 59 - 3.575 3.572 -0.010
ENSG00000167085 E016 3211.3372022 9.184142e-03 6.403878e-02 0.2117497850 17 49409135 49409158 24 - 3.479 3.433 -0.153
ENSG00000167085 E017 5295.4372188 1.228995e-02 1.637512e-01 0.3822713980 17 49409331 49409448 118 - 3.684 3.655 -0.098
ENSG00000167085 E018 2979.8674351 1.211824e-02 2.481913e-01 0.4860140099 17 49409449 49409473 25 - 3.429 3.407 -0.072
ENSG00000167085 E019 6049.6923309 1.420632e-02 1.820096e-01 0.4065893200 17 49411678 49411839 162 - 3.743 3.712 -0.103
ENSG00000167085 E020 16.7209958 2.479372e-03 3.844249e-03 0.0282725723 17 49411840 49412234 395 - 1.351 1.118 -0.821
ENSG00000167085 E021 6.9207606 4.231060e-03 2.211925e-03 0.0184726123 17 49412686 49413176 491 - 1.079 0.729 -1.336
ENSG00000167085 E022 3807.3166171 1.206084e-02 1.910908e-01 0.4182903741 17 49413177 49413291 115 - 3.541 3.512 -0.096
ENSG00000167085 E023 68.5458161 5.482297e-04 2.037924e-03 0.0173161699 17 49414242 49414333 92 - 1.870 1.752 -0.398
ENSG00000167085 E024 38.4229139 4.116962e-03 3.788081e-02 0.1493004969 17 49414740 49414741 2 - 1.625 1.510 -0.394
ENSG00000167085 E025 47.6304153 1.816501e-03 8.944865e-03 0.0535704554 17 49414742 49414743 2 - 1.721 1.595 -0.427
ENSG00000167085 E026 50.4977932 3.675328e-03 4.460539e-02 0.1666231413 17 49414744 49414747 4 - 1.726 1.629 -0.328
ENSG00000167085 E027 77.5843949 8.817488e-03 3.121116e-01 0.5524616234 17 49414748 49414834 87 - 1.863 1.828 -0.116
ENSG00000167085 E028 1924.0537860 1.376868e-02 1.123774e-01 0.3031027655 17 49414835 49414905 71 - 3.262 3.209 -0.175