ENSG00000167004

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300289 ENSG00000167004 HEK293_OSMI2_6hA HEK293_TMG_6hB PDIA3 protein_coding protein_coding 398.205 250.9672 452.7996 45.22582 14.22436 0.8513481 112.0032 76.84180 117.1435 13.942225 3.568324 0.6082495 0.2930458 0.3059667 0.2587333 -0.04723333 0.03911736 0.03911736 FALSE TRUE
ENST00000686374 ENSG00000167004 HEK293_OSMI2_6hA HEK293_TMG_6hB PDIA3 protein_coding retained_intron 398.205 250.9672 452.7996 45.22582 14.22436 0.8513481 124.7419 97.32048 155.9522 22.862213 7.232523 0.6802330 0.3406792 0.3798667 0.3441333 -0.03573333 0.81166780 0.03911736 FALSE FALSE
ENST00000686929 ENSG00000167004 HEK293_OSMI2_6hA HEK293_TMG_6hB PDIA3 protein_coding protein_coding 398.205 250.9672 452.7996 45.22582 14.22436 0.8513481 130.3494 68.19867 170.5266 9.527693 5.143983 1.3220547 0.3075625 0.2771333 0.3766667 0.09953333 0.04471307 0.03911736 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000167004 E001 1.5550149 0.0190564687 2.203481e-02 1.027021e-01 15 43746394 43746404 11 + 0.193 0.599 2.413
ENSG00000167004 E002 2.3650420 0.0097254658 2.181979e-02 1.019788e-01 15 43746405 43746407 3 + 0.326 0.707 1.875
ENSG00000167004 E003 2.8047622 0.0102174507 1.683049e-02 8.484088e-02 15 43746408 43746409 2 + 0.379 0.766 1.792
ENSG00000167004 E004 4.3825023 0.0071112324 1.033217e-03 1.016344e-02 15 43746410 43746422 13 + 0.470 0.945 1.999
ENSG00000167004 E005 4.3825023 0.0071112324 1.033217e-03 1.016344e-02 15 43746423 43746424 2 + 0.470 0.945 1.999
ENSG00000167004 E006 6.2407597 0.0371191660 4.051523e-04 4.779396e-03 15 43746425 43746427 3 + 0.546 1.093 2.180
ENSG00000167004 E007 14.7421750 0.0260653803 5.909837e-07 1.796360e-05 15 43746428 43746436 9 + 0.835 1.444 2.197
ENSG00000167004 E008 15.0757774 0.0241744427 2.205523e-07 7.512003e-06 15 43746437 43746437 1 + 0.835 1.456 2.237
ENSG00000167004 E009 16.1661341 0.0386636998 1.814566e-06 4.787246e-05 15 43746438 43746438 1 + 0.852 1.486 2.274
ENSG00000167004 E010 22.7192420 0.0449089161 1.207215e-07 4.394704e-06 15 43746439 43746441 3 + 0.942 1.639 2.457
ENSG00000167004 E011 36.8926396 0.1634672559 1.516969e-03 1.373417e-02 15 43746442 43746447 6 + 1.193 1.823 2.167
ENSG00000167004 E012 41.9379681 0.1730595267 9.016861e-04 9.107993e-03 15 43746448 43746448 1 + 1.214 1.887 2.309
ENSG00000167004 E013 75.9878241 0.3701187111 2.260047e-02 1.045998e-01 15 43746449 43746451 3 + 1.531 2.120 1.988
ENSG00000167004 E014 77.3440489 0.3744206398 2.266150e-02 1.048275e-01 15 43746452 43746452 1 + 1.537 2.128 1.993
ENSG00000167004 E015 132.9666139 0.4768431465 2.165656e-02 1.014643e-01 15 43746453 43746483 31 + 1.708 2.380 2.255
ENSG00000167004 E016 298.1116719 0.9410232316 1.830257e-01 4.078624e-01 15 43746484 43746570 87 + 2.208 2.675 1.558
ENSG00000167004 E017 797.9056403 1.9101040667 5.372094e-01 7.271275e-01 15 43746571 43746706 136 + 2.800 3.001 0.671
ENSG00000167004 E018 0.0000000       15 43750201 43750446 246 +      
ENSG00000167004 E019 0.1723744 0.0480971616 3.752549e-01   15 43751189 43751505 317 + 0.000 0.138 11.120
ENSG00000167004 E020 0.3751086 0.0276821414 1.359295e-01   15 43751506 43751583 78 + 0.000 0.242 12.122
ENSG00000167004 E021 0.5061644 0.4914534184 5.371614e-01   15 43751584 43751758 175 + 0.107 0.246 1.442
ENSG00000167004 E022 0.3393995 0.0251056558 2.870503e-01   15 43752802 43752946 145 + 0.193 0.000 -11.319
ENSG00000167004 E023 969.2910524 0.0535439846 7.041764e-01 8.382470e-01 15 43753824 43753902 79 + 2.976 2.993 0.057
ENSG00000167004 E024 1.5787356 0.0132376294 6.733232e-01 8.184801e-01 15 43756628 43756648 21 + 0.379 0.457 0.418
ENSG00000167004 E025 1375.0152239 0.0044840393 1.622608e-01 3.801635e-01 15 43756649 43756766 118 + 3.153 3.111 -0.137
ENSG00000167004 E026 10.8958858 0.1790409565 3.368018e-01 5.752226e-01 15 43756767 43759996 3230 + 1.133 0.973 -0.582
ENSG00000167004 E027 1697.4699672 0.0002575585 5.936605e-11 4.402498e-09 15 43761424 43761531 108 + 3.254 3.189 -0.217
ENSG00000167004 E028 2.2680683 0.0534408288 6.464018e-01 8.011114e-01 15 43761532 43762181 650 + 0.543 0.460 -0.406
ENSG00000167004 E029 1678.8288611 0.0013342487 7.211593e-06 1.579028e-04 15 43763077 43763151 75 + 3.253 3.176 -0.257
ENSG00000167004 E030 1774.6068936 0.0019327426 2.383134e-05 4.434703e-04 15 43763152 43763206 55 + 3.280 3.195 -0.281
ENSG00000167004 E031 0.8875026 0.0229148003 8.838945e-01   15 43765435 43765449 15 + 0.264 0.243 -0.163
ENSG00000167004 E032 2367.7164690 0.0014283552 1.078690e-07 3.966789e-06 15 43765450 43765566 117 + 3.408 3.317 -0.304
ENSG00000167004 E033 2.3378568 0.0093376054 1.920860e-01 4.194876e-01 15 43765567 43765886 320 + 0.610 0.396 -1.042
ENSG00000167004 E034 2247.3632331 0.0013973974 4.559931e-03 3.226185e-02 15 43765887 43766012 126 + 3.366 3.323 -0.144
ENSG00000167004 E035 2386.1610501 0.0013412723 3.142367e-01 5.544730e-01 15 43766728 43766910 183 + 3.377 3.370 -0.024
ENSG00000167004 E036 5.0512996 0.0859354535 5.430066e-01 7.312077e-01 15 43766911 43767522 612 + 0.818 0.712 -0.424
ENSG00000167004 E037 1729.5991963 0.0015120757 9.846355e-01 9.941482e-01 15 43768489 43768597 109 + 3.229 3.240 0.037
ENSG00000167004 E038 2.4031180 0.0096571858 4.428431e-01 6.606327e-01 15 43768598 43769496 899 + 0.470 0.600 0.611
ENSG00000167004 E039 1.5288595 0.0155351720 6.922011e-01 8.304549e-01 15 43769497 43769517 21 + 0.379 0.456 0.413
ENSG00000167004 E040 795.0762798 0.0002896662 3.029592e-01 5.435439e-01 15 43769518 43769521 4 + 2.886 2.911 0.083
ENSG00000167004 E041 1809.2230022 0.0004574100 3.697706e-02 1.468490e-01 15 43769522 43769646 125 + 3.237 3.274 0.124
ENSG00000167004 E042 2.7997386 0.0123966974 4.073722e-01 6.339858e-01 15 43769647 43770249 603 + 0.638 0.510 -0.582
ENSG00000167004 E043 999.3567127 0.0001116483 2.065595e-05 3.927730e-04 15 43770250 43770254 5 + 2.969 3.029 0.202
ENSG00000167004 E044 1851.8616810 0.0012725731 4.343461e-02 1.636766e-01 15 43770255 43770329 75 + 3.241 3.291 0.166
ENSG00000167004 E045 7.4745410 0.0092190232 8.640981e-01 9.326942e-01 15 43770330 43770522 193 + 0.902 0.929 0.103
ENSG00000167004 E046 1655.0113705 0.0020465888 4.808358e-01 6.876376e-01 15 43770523 43770571 49 + 3.201 3.231 0.099
ENSG00000167004 E047 1129.5094579 0.0013054137 8.055481e-01 8.994003e-01 15 43770572 43770580 9 + 3.041 3.058 0.056
ENSG00000167004 E048 9.9984095 0.0032399651 1.895988e-01 4.164336e-01 15 43770581 43771085 505 + 1.095 0.964 -0.481
ENSG00000167004 E049 1.8204033 0.0114953405 6.476798e-01 8.019813e-01 15 43771086 43771104 19 + 0.471 0.397 -0.390
ENSG00000167004 E050 3236.7013788 0.0013624464 5.110414e-02 1.823209e-01 15 43771105 43773279 2175 + 3.485 3.532 0.156