ENSG00000166938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319194 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding protein_coding 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 1.0163781 0.3239837 1.521855 0.2093013 0.3718211 2.1974301 0.060000000 0.02970000 0.07046667 0.04076667 6.322079e-01 1.380802e-10 FALSE TRUE
ENST00000319212 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding protein_coding 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 2.8401979 2.2914567 3.488357 0.2832721 0.4908792 0.6041301 0.199770833 0.24136667 0.16233333 -0.07903333 5.284300e-01 1.380802e-10 FALSE TRUE
ENST00000530537 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding nonsense_mediated_decay 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 0.8294103 1.6450876 0.675052 0.9215268 0.6750520 -1.2726221 0.070008333 0.15210000 0.02813333 -0.12396667 5.930970e-01 1.380802e-10 FALSE TRUE
ENST00000532293 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding processed_transcript 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 0.9259165 0.7922165 1.070130 0.4125462 0.1651982 0.4291409 0.062704167 0.07283333 0.04953333 -0.02330000 1.000000e+00 1.380802e-10 FALSE FALSE
ENST00000562314 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding retained_intron 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 0.3314576 0.0000000 2.053484 0.0000000 0.4236847 7.6889381 0.016287500 0.00000000 0.09253333 0.09253333 1.380802e-10 1.380802e-10 FALSE FALSE
ENST00000564909 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding retained_intron 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 4.6057476 2.5874080 5.357195 0.2261313 1.0128113 1.0470958 0.274895833 0.27326667 0.24180000 -0.03146667 8.869064e-01 1.380802e-10 FALSE TRUE
ENST00000564945 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding retained_intron 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 1.2328099 0.3073041 2.168992 0.1884754 0.4624197 2.7797228 0.072020833 0.03896667 0.09756667 0.05860000 5.633237e-01 1.380802e-10 FALSE FALSE
ENST00000568874 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding processed_transcript 15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 0.8350823 0.4274188 1.437336 0.1606859 0.1127431 1.7263123 0.052837500 0.04670000 0.06650000 0.01980000 7.983641e-01 1.380802e-10   FALSE
MSTRG.11076.10 ENSG00000166938 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3L protein_coding   15.49281 9.601021 21.87382 1.254573 1.116302 1.187103 0.1385224 0.0000000 1.063786 0.0000000 1.0637857 6.7465623 0.006970833 0.00000000 0.05270000 0.05270000 9.729402e-01 1.380802e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166938 E001 0.1779838 0.0335522747 0.695214688   15 66293217 66293236 20 + 0.103 0.000 -9.538
ENSG00000166938 E002 0.1779838 0.0335522747 0.695214688   15 66293237 66293259 23 + 0.103 0.000 -9.535
ENSG00000166938 E003 0.7970432 0.0173673903 0.336045562   15 66293260 66293290 31 + 0.315 0.144 -1.441
ENSG00000166938 E004 1.4051438 0.0142427293 0.054471939 0.19017680 15 66293291 66293306 16 + 0.495 0.143 -2.440
ENSG00000166938 E005 2.2809502 0.1406915900 0.449118876 0.66511485 15 66293307 66293336 30 + 0.587 0.408 -0.878
ENSG00000166938 E006 1.9707428 0.0271684078 0.480514025 0.68743805 15 66293337 66293367 31 + 0.530 0.408 -0.613
ENSG00000166938 E007 0.9291287 0.0162409798 0.034172468   15 66293501 66293567 67 + 0.102 0.470 2.877
ENSG00000166938 E008 0.9291287 0.0162409798 0.034172468   15 66293568 66293571 4 + 0.102 0.470 2.877
ENSG00000166938 E009 3.1071472 0.0087739937 0.009802739 0.05727219 15 66293572 66293587 16 + 0.414 0.811 1.780
ENSG00000166938 E010 7.0927024 0.0045468827 0.069410459 0.22356909 15 66293588 66293595 8 + 0.801 1.017 0.821
ENSG00000166938 E011 11.8619417 0.0158909489 0.260612550 0.49961240 15 66293596 66293638 43 + 1.046 1.168 0.442
ENSG00000166938 E012 18.4001172 0.0107877243 0.579856063 0.75712273 15 66293639 66293735 97 + 1.262 1.312 0.177
ENSG00000166938 E013 1.7072032 0.0148208354 0.135165379 0.33998149 15 66293832 66293842 11 + 0.314 0.572 1.364
ENSG00000166938 E014 3.7428473 0.0256009407 0.236128486 0.47208184 15 66293843 66293916 74 + 0.593 0.783 0.794
ENSG00000166938 E015 4.0164676 0.0064769066 0.265352809 0.50473802 15 66293917 66293993 77 + 0.622 0.784 0.671
ENSG00000166938 E016 4.8734227 0.0059536245 0.173526847 0.39525623 15 66293994 66294058 65 + 0.674 0.861 0.749
ENSG00000166938 E017 9.1278667 0.0034028968 0.545182245 0.73280844 15 66294059 66294174 116 + 0.966 1.033 0.248
ENSG00000166938 E018 7.1229284 0.0043926996 0.073699104 0.23216106 15 66294175 66294448 274 + 0.978 0.756 -0.858
ENSG00000166938 E019 54.0735327 0.0099556862 0.395986815 0.62517588 15 66294988 66295096 109 + 1.758 1.698 -0.202
ENSG00000166938 E020 42.6862793 0.0009186506 0.027607936 0.12013997 15 66295097 66295141 45 + 1.680 1.559 -0.411
ENSG00000166938 E021 0.6951069 0.6896485152 0.450159529   15 66306762 66306819 58 + 0.104 0.344 2.155
ENSG00000166938 E022 0.7007164 0.6026223519 0.768927791   15 66306820 66306823 4 + 0.190 0.255 0.543
ENSG00000166938 E023 48.8347108 0.0009374344 0.178094316 0.40130712 15 66306824 66306896 73 + 1.719 1.651 -0.229
ENSG00000166938 E024 60.5073570 0.0007056382 0.181793670 0.40635402 15 66306897 66306952 56 + 1.806 1.746 -0.203
ENSG00000166938 E025 96.3916381 0.0005667445 0.037552073 0.14845902 15 66308709 66308844 136 + 2.010 1.934 -0.254
ENSG00000166938 E026 109.6328384 0.0007577756 0.645627158 0.80057664 15 66311724 66311900 177 + 2.042 2.028 -0.048
ENSG00000166938 E027 0.1426347 0.0323740156 0.695573004   15 66311901 66311901 1 + 0.102 0.000 -9.531
ENSG00000166938 E028 74.2938526 0.0356054201 0.118052151 0.31267686 15 66314039 66314117 79 + 1.805 1.950 0.487
ENSG00000166938 E029 107.5461261 0.0682811969 0.236625382 0.47266905 15 66315036 66315215 180 + 1.972 2.100 0.429
ENSG00000166938 E030 125.8003482 0.0113092381 0.624097841 0.78669691 15 66318449 66318618 170 + 2.085 2.114 0.096
ENSG00000166938 E031 76.1459530 0.0041223059 0.393337130 0.62303534 15 66320571 66320649 79 + 1.897 1.858 -0.131
ENSG00000166938 E032 77.4591568 0.0039290959 0.413539241 0.63866358 15 66320650 66320732 83 + 1.902 1.864 -0.128
ENSG00000166938 E033 135.7493785 0.0044138623 0.983575740 0.99360929 15 66322687 66322934 248 + 2.127 2.126 -0.003
ENSG00000166938 E034 89.0589015 0.0039387806 0.471860837 0.68142265 15 66323493 66323585 93 + 1.934 1.968 0.114
ENSG00000166938 E035 216.1032609 0.0008603189 0.181757959 0.40630093 15 66325831 66326364 534 + 2.314 2.352 0.124
ENSG00000166938 E036 5.8347754 0.0376589687 0.577377761 0.75536765 15 66326365 66326561 197 + 0.785 0.862 0.301
ENSG00000166938 E037 47.3384132 0.0010174044 0.701690445 0.83666730 15 66328970 66328996 27 + 1.672 1.695 0.076
ENSG00000166938 E038 68.7524820 0.0007756977 0.464579270 0.67630377 15 66328997 66329124 128 + 1.824 1.858 0.115
ENSG00000166938 E039 54.1856897 0.0006508929 0.584377833 0.75991560 15 66329221 66329279 59 + 1.721 1.750 0.097
ENSG00000166938 E040 83.1512436 0.0004610195 0.256348979 0.49511272 15 66329280 66329399 120 + 1.897 1.944 0.156
ENSG00000166938 E041 8.4499293 0.0040700275 0.001409452 0.01296697 15 66329400 66329548 149 + 1.085 0.692 -1.512
ENSG00000166938 E042 12.7964440 0.0354784724 0.142067314 0.35052518 15 66329613 66330024 412 + 1.203 1.014 -0.679
ENSG00000166938 E043 90.9445973 0.0006434749 0.288266613 0.52900630 15 66331875 66332020 146 + 1.936 1.979 0.143
ENSG00000166938 E044 15.8422634 0.5437208307 0.222554320 0.45655279 15 66332021 66332735 715 + 1.411 0.519 -3.427
ENSG00000166938 E045 122.1368891 0.0056294542 0.701856022 0.83675897 15 66332736 66332910 175 + 2.088 2.070 -0.061
ENSG00000166938 E046 6.4973277 1.0387908308 0.589773704 0.76356743 15 66332911 66333003 93 + 1.052 0.246 -3.751
ENSG00000166938 E047 297.7497469 0.0290028116 0.846145482 0.92278968 15 66333004 66335186 2183 + 2.478 2.451 -0.090