ENSG00000166833

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349880 ENSG00000166833 HEK293_OSMI2_6hA HEK293_TMG_6hB NAV2 protein_coding protein_coding 0.8466418 1.139085 0.466246 0.05064026 0.05275411 -1.270707 0.15377046 0.24473061 0.23774221 0.12238020 0.05018311 -0.04013263 0.2341417 0.21373333 0.5427667 0.32903333 5.591599e-01 3.930971e-05 FALSE TRUE
ENST00000360655 ENSG00000166833 HEK293_OSMI2_6hA HEK293_TMG_6hB NAV2 protein_coding protein_coding 0.8466418 1.139085 0.466246 0.05064026 0.05275411 -1.270707 0.09491618 0.13743068 0.00000000 0.07031467 0.00000000 -3.88196491 0.1247292 0.11793333 0.0000000 -0.11793333 5.670844e-01 3.930971e-05 FALSE TRUE
ENST00000396085 ENSG00000166833 HEK293_OSMI2_6hA HEK293_TMG_6hB NAV2 protein_coding protein_coding 0.8466418 1.139085 0.466246 0.05064026 0.05275411 -1.270707 0.02568593 0.06406191 0.00000000 0.03335007 0.00000000 -2.88873166 0.0285125 0.05853333 0.0000000 -0.05853333 7.094541e-01 3.930971e-05 FALSE TRUE
ENST00000525025 ENSG00000166833 HEK293_OSMI2_6hA HEK293_TMG_6hB NAV2 protein_coding retained_intron 0.8466418 1.139085 0.466246 0.05064026 0.05275411 -1.270707 0.02807560 0.00000000 0.03127285 0.00000000 0.03127285 2.04519292 0.0288000 0.00000000 0.0547000 0.05470000 6.616162e-01 3.930971e-05   FALSE
ENST00000528923 ENSG00000166833 HEK293_OSMI2_6hA HEK293_TMG_6hB NAV2 protein_coding retained_intron 0.8466418 1.139085 0.466246 0.05064026 0.05275411 -1.270707 0.30079621 0.51165129 0.00000000 0.07021963 0.00000000 -5.70501382 0.2793750 0.44563333 0.0000000 -0.44563333 3.930971e-05 3.930971e-05   FALSE
ENST00000533917 ENSG00000166833 HEK293_OSMI2_6hA HEK293_TMG_6hB NAV2 protein_coding protein_coding 0.8466418 1.139085 0.466246 0.05064026 0.05275411 -1.270707 0.16245606 0.15703664 0.17210423 0.08021634 0.04815527 0.12459984 0.2092458 0.14366667 0.3585667 0.21490000 6.092294e-01 3.930971e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166833 E001 0.0000000       11 19350724 19351027 304 +      
ENSG00000166833 E002 3.9903593 0.0266884802 0.1803286385 0.40444209 11 19712837 19713596 760 + 0.812 0.613 -0.824
ENSG00000166833 E003 1.5818719 0.1194381993 0.9999196126 1.00000000 11 19713597 19713962 366 + 0.394 0.392 -0.013
ENSG00000166833 E004 0.0000000       11 19777802 19777982 181 +      
ENSG00000166833 E005 0.0000000       11 19813718 19813855 138 +      
ENSG00000166833 E006 1.2665030 0.0142691479 0.2257291864   11 19832484 19832601 118 + 0.477 0.263 -1.261
ENSG00000166833 E007 1.4506439 0.0141835922 0.1069893864 0.29397094 11 19842871 19842923 53 + 0.543 0.264 -1.580
ENSG00000166833 E008 1.6283674 0.1750753195 0.8547023546 0.92743709 11 19868925 19868997 73 + 0.396 0.394 -0.013
ENSG00000166833 E009 2.6453102 0.0824657859 0.4556878213 0.67001682 11 19879869 19880127 259 + 0.398 0.572 0.862
ENSG00000166833 E010 0.0000000       11 19884294 19884362 69 +      
ENSG00000166833 E011 1.5334686 0.2245420813 0.4186641588 0.64261284 11 19892434 19892594 161 + 0.477 0.317 -0.894
ENSG00000166833 E012 0.0000000       11 19931765 19931790 26 +      
ENSG00000166833 E013 10.3627227 0.0039484657 0.1728150162 0.39423069 11 19933176 19934277 1102 + 1.113 0.971 -0.519
ENSG00000166833 E014 3.7038388 0.0358912623 0.3192420334 0.55897144 11 19939661 19939773 113 + 0.739 0.574 -0.706
ENSG00000166833 E015 3.1124939 0.0795076991 0.7503604269 0.86695297 11 19946401 19946509 109 + 0.602 0.552 -0.223
ENSG00000166833 E016 7.8027507 0.0038238393 0.8468769621 0.92322928 11 19948691 19949080 390 + 0.929 0.908 -0.079
ENSG00000166833 E017 3.9911442 0.1089169807 0.7450402943 0.86368710 11 19984125 19984247 123 + 0.700 0.666 -0.142
ENSG00000166833 E018 0.0000000       11 20022556 20022795 240 +      
ENSG00000166833 E019 0.0000000       11 20022838 20022844 7 +      
ENSG00000166833 E020 0.0000000       11 20022845 20022902 58 +      
ENSG00000166833 E021 0.0000000       11 20022903 20023089 187 +      
ENSG00000166833 E022 0.0000000       11 20023090 20023132 43 +      
ENSG00000166833 E023 0.0000000       11 20027255 20027467 213 +      
ENSG00000166833 E024 0.0000000       11 20027554 20027701 148 +      
ENSG00000166833 E025 3.8235082 0.0074902579 0.2085391976 0.44011523 11 20035959 20036097 139 + 0.778 0.593 -0.775
ENSG00000166833 E026 5.1815658 0.0237634562 0.6044941780 0.77319436 11 20043981 20044272 292 + 0.811 0.732 -0.318
ENSG00000166833 E027 8.2633087 0.0081805883 0.1027095285 0.28662767 11 20044968 20045670 703 + 1.059 0.873 -0.695
ENSG00000166833 E028 7.2884359 0.0191536983 0.0353506416 0.14249469 11 20048728 20049195 468 + 0.652 0.967 1.246
ENSG00000166833 E029 2.0403053 0.1089004421 0.0904732925 0.26463504 11 20049836 20049901 66 + 0.175 0.559 2.398
ENSG00000166833 E030 1.5050662 0.0149925630 0.0174124581 0.08696653 11 20051289 20051333 45 + 0.000 0.488 13.235
ENSG00000166833 E031 4.2308279 0.0068164542 0.9727683320 0.98834813 11 20054080 20054240 161 + 0.698 0.695 -0.012
ENSG00000166833 E032 6.3392067 0.0525726400 0.2103190574 0.44217906 11 20055769 20055957 189 + 0.956 0.762 -0.751
ENSG00000166833 E033 0.1614157 0.0317192998 0.2007498237   11 20056530 20056628 99 + 0.176 0.000 -12.833
ENSG00000166833 E034 2.3222482 0.0625116620 0.3410199186 0.57895688 11 20062307 20062359 53 + 0.604 0.426 -0.856
ENSG00000166833 E035 2.1855829 0.0585273090 0.9266845584 0.96542125 11 20068186 20068209 24 + 0.478 0.460 -0.092
ENSG00000166833 E036 3.0065687 0.0090317979 0.8789690688 0.94073449 11 20068324 20068398 75 + 0.544 0.570 0.121
ENSG00000166833 E037 3.3649215 0.0308200138 0.3581808946 0.59436040 11 20077552 20077635 84 + 0.477 0.639 0.749
ENSG00000166833 E038 4.3171507 0.0067884414 0.7776548865 0.88327770 11 20077993 20078104 112 + 0.652 0.696 0.184
ENSG00000166833 E039 4.2013028 0.1290271300 0.7542367065 0.86926238 11 20080064 20080209 146 + 0.604 0.691 0.373
ENSG00000166833 E040 0.3751086 0.0253311976 0.5607436812   11 20082592 20082600 9 + 0.000 0.152 11.264
ENSG00000166833 E041 4.9043047 0.2361378342 0.7691291015 0.87813227 11 20083007 20083179 173 + 0.790 0.695 -0.384
ENSG00000166833 E042 4.1846375 0.0062356077 0.5670216587 0.74800742 11 20090865 20091018 154 + 0.740 0.657 -0.342
ENSG00000166833 E043 5.9212907 0.0056706431 0.1876017119 0.41388453 11 20092206 20092368 163 + 0.929 0.762 -0.645
ENSG00000166833 E044 4.7815376 0.1365697994 0.7386957491 0.85967126 11 20093099 20093199 101 + 0.774 0.729 -0.182
ENSG00000166833 E045 5.4770586 0.0049731859 0.4650060020 0.67659439 11 20095672 20095767 96 + 0.844 0.747 -0.383
ENSG00000166833 E046 7.0360903 0.0150905990 0.3552913464 0.59195510 11 20097577 20097745 169 + 0.953 0.834 -0.453
ENSG00000166833 E047 7.4580991 0.0048547348 0.6853495696 0.82608586 11 20100937 20101172 236 + 0.844 0.897 0.204
ENSG00000166833 E048 6.6594060 0.0404731725 0.8457916340 0.92255190 11 20103255 20103409 155 + 0.813 0.852 0.155
ENSG00000166833 E049 4.7885159 0.0453400248 0.8856430241 0.94433631 11 20103653 20103724 72 + 0.699 0.719 0.082
ENSG00000166833 E050 0.1308682 0.0326491905 1.0000000000   11 20104211 20105530 1320 + 0.000 0.082 10.328
ENSG00000166833 E051 7.0439575 0.0048927081 0.4452554625 0.66225169 11 20105531 20105727 197 + 0.929 0.835 -0.358
ENSG00000166833 E052 0.0000000       11 20107245 20107663 419 +      
ENSG00000166833 E053 5.2378075 0.0050835193 0.3913359597 0.62148574 11 20107664 20107782 119 + 0.844 0.730 -0.452
ENSG00000166833 E054 0.1308682 0.0326491905 1.0000000000   11 20114383 20114591 209 + 0.000 0.082 10.328
ENSG00000166833 E055 6.9183708 0.0047963314 0.3735963215 0.60703427 11 20114592 20114795 204 + 0.777 0.896 0.463
ENSG00000166833 E056 78.0233086 0.0008176692 0.0006665836 0.00715196 11 20118133 20121601 3469 + 1.759 1.893 0.453