ENSG00000166747

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299980 ENSG00000166747 HEK293_OSMI2_6hA HEK293_TMG_6hB AP1G1 protein_coding protein_coding 26.04688 16.35494 36.28058 4.509015 2.348129 1.148987 19.3161186 13.2906414 24.244908 4.3164882 2.8771338 0.8667809 0.76607083 0.78403333 0.6632333 -0.12080000 0.5498681431 0.0002822036 FALSE TRUE
ENST00000393512 ENSG00000166747 HEK293_OSMI2_6hA HEK293_TMG_6hB AP1G1 protein_coding protein_coding 26.04688 16.35494 36.28058 4.509015 2.348129 1.148987 3.2625032 0.7966945 7.414066 0.2143063 0.4068622 3.2021152 0.10262083 0.05183333 0.2077667 0.15593333 0.0002822036 0.0002822036 FALSE TRUE
ENST00000570052 ENSG00000166747 HEK293_OSMI2_6hA HEK293_TMG_6hB AP1G1 protein_coding retained_intron 26.04688 16.35494 36.28058 4.509015 2.348129 1.148987 0.6007382 1.1195149 0.000000 0.6835964 0.0000000 -6.8195596 0.02942917 0.08586667 0.0000000 -0.08586667 0.2166077866 0.0002822036   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166747 E001 1216.5412591 1.9438351965 4.051449e-01 0.6323971995 16 71729000 71731882 2883 - 2.865 3.306 1.465
ENSG00000166747 E002 328.3002407 1.5809867007 4.611497e-01 0.6739286346 16 71731883 71732384 502 - 2.346 2.688 1.140
ENSG00000166747 E003 163.9941311 1.2722361872 3.653967e-01 0.6002569262 16 71732385 71732534 150 - 2.023 2.412 1.300
ENSG00000166747 E004 145.3357786 1.2480099419 3.988845e-01 0.6273130289 16 71732535 71732602 68 - 1.993 2.336 1.146
ENSG00000166747 E005 220.8007601 1.4016994535 4.414800e-01 0.6597337406 16 71732603 71732799 197 - 2.180 2.510 1.102
ENSG00000166747 E006 277.0665494 1.4912818265 4.770580e-01 0.6850120961 16 71732800 71733159 360 - 2.292 2.591 0.997
ENSG00000166747 E007 1.4652434 0.0124397189 4.216672e-01 0.6448802268 16 71734571 71734608 38 - 0.380 0.310 -0.424
ENSG00000166747 E008 150.7992625 0.0088796074 8.421774e-02 0.2531989272 16 71734609 71734707 99 - 2.062 2.286 0.749
ENSG00000166747 E009 202.6457089 0.0116485986 5.330487e-01 0.7242262313 16 71738942 71739102 161 - 2.226 2.347 0.403
ENSG00000166747 E010 144.9026906 0.0383061141 5.206067e-01 0.7153340034 16 71739234 71739341 108 - 2.087 2.191 0.351
ENSG00000166747 E011 0.8621321 0.6924799936 9.239083e-01   16 71742282 71743593 1312 - 0.210 0.315 0.782
ENSG00000166747 E012 160.2273287 0.0225799131 1.654969e-01 0.3845440827 16 71745144 71745270 127 - 2.142 2.209 0.221
ENSG00000166747 E013 190.7535779 0.0292169380 2.323871e-01 0.4679631735 16 71745473 71745614 142 - 2.214 2.292 0.261
ENSG00000166747 E014 174.7510819 0.0233141461 2.435165e-01 0.4805329488 16 71746588 71746692 105 - 2.178 2.251 0.243
ENSG00000166747 E015 5.4788301 0.0449317095 2.735851e-01 0.5134319670 16 71746693 71747396 704 - 0.779 0.718 -0.249
ENSG00000166747 E016 104.8537072 0.0218753145 2.840652e-01 0.5245527080 16 71748251 71748267 17 - 1.959 2.026 0.224
ENSG00000166747 E017 163.5697285 0.0312479757 3.148568e-01 0.5550022660 16 71748268 71748378 111 - 2.150 2.219 0.229
ENSG00000166747 E018 102.0735113 0.0295543055 3.122895e-01 0.5526038057 16 71749894 71749918 25 - 1.945 2.022 0.261
ENSG00000166747 E019 110.1312368 0.0282208933 1.677154e-01 0.3875619840 16 71749919 71749983 65 - 1.988 2.031 0.143
ENSG00000166747 E020 158.5870666 0.0306453781 1.459324e-01 0.3562762071 16 71750210 71750332 123 - 2.149 2.177 0.091
ENSG00000166747 E021 0.8380019 0.2128041637 1.083984e-01   16 71750333 71750480 148 - 0.304 0.000 -13.166
ENSG00000166747 E022 0.3337900 0.0584838930 6.351592e-01   16 71751263 71751337 75 - 0.079 0.182 1.382
ENSG00000166747 E023 3.1465963 0.2418267967 3.894344e-01 0.6200129719 16 71753570 71753832 263 - 0.605 0.497 -0.497
ENSG00000166747 E024 116.7629171 0.0306568476 1.147757e-01 0.3070744392 16 71753833 71753887 55 - 2.025 2.028 0.009
ENSG00000166747 E025 0.0000000       16 71755965 71756018 54 -      
ENSG00000166747 E026 169.4931962 0.0316034665 7.184000e-02 0.2284916590 16 71756019 71756159 141 - 2.184 2.189 0.015
ENSG00000166747 E027 0.7852767 0.0172671820 8.132409e-01   16 71756160 71756324 165 - 0.204 0.310 0.794
ENSG00000166747 E028 145.0609642 0.0212859427 1.093522e-02 0.0620963163 16 71758808 71758896 89 - 2.126 2.098 -0.095
ENSG00000166747 E029 94.1597629 0.0131763425 1.262817e-03 0.0118805262 16 71758897 71758921 25 - 1.948 1.890 -0.198
ENSG00000166747 E030 116.3172755 0.0232445885 2.255876e-04 0.0029532811 16 71761512 71761567 56 - 2.059 1.920 -0.467
ENSG00000166747 E031 0.1614157 0.0334296488 9.163048e-01   16 71764346 71764349 4 - 0.079 0.000 -10.827
ENSG00000166747 E032 147.8822370 0.0394655092 4.133566e-03 0.0299132622 16 71764350 71764448 99 - 2.163 2.020 -0.479
ENSG00000166747 E033 134.2087735 0.0356497259 6.803615e-03 0.0437075987 16 71764646 71764726 81 - 2.114 2.003 -0.372
ENSG00000166747 E034 125.9212260 0.0464381654 2.094842e-02 0.0991693281 16 71765489 71765584 96 - 2.087 1.977 -0.369
ENSG00000166747 E035 0.9396778 0.0159599627 3.369853e-01   16 71765585 71765650 66 - 0.301 0.182 -0.939
ENSG00000166747 E036 15.6304941 0.0440401019 4.822290e-01 0.6885295388 16 71767877 71767885 9 - 1.168 1.207 0.138
ENSG00000166747 E037 0.1779838 0.1318273094 9.199761e-01   16 71769619 71769622 4 - 0.080 0.000 -10.833
ENSG00000166747 E038 84.8637465 0.0415551519 1.412903e-02 0.0748653320 16 71769623 71769699 77 - 1.919 1.803 -0.392
ENSG00000166747 E039 0.3040503 0.0244411696 4.498713e-01   16 71771140 71771155 16 - 0.146 0.000 -11.826
ENSG00000166747 E040 43.2455972 0.0179409432 7.978499e-03 0.0492076515 16 71771156 71771159 4 - 1.624 1.551 -0.249
ENSG00000166747 E041 86.1940332 0.0330909351 3.941615e-03 0.0288176699 16 71771160 71771252 93 - 1.927 1.803 -0.418
ENSG00000166747 E042 0.1779838 0.1318273094 9.199761e-01   16 71772960 71773053 94 - 0.080 0.000 -10.833
ENSG00000166747 E043 75.0829060 0.0493166842 6.535668e-03 0.0423903573 16 71773221 71773254 34 - 1.878 1.706 -0.582
ENSG00000166747 E044 57.8907039 0.0488087262 9.232461e-03 0.0548422181 16 71773255 71773269 15 - 1.767 1.597 -0.577
ENSG00000166747 E045 115.7258682 0.0305520701 4.305530e-03 0.0308644186 16 71773270 71773362 93 - 2.051 1.937 -0.382
ENSG00000166747 E046 0.1723744 0.1603866305 2.712769e-01   16 71774332 71774467 136 - 0.000 0.183 13.553
ENSG00000166747 E047 100.2394635 0.0267950219 1.768215e-03 0.0154873126 16 71774468 71774518 51 - 1.991 1.867 -0.418
ENSG00000166747 E048 71.1835214 0.0113673692 2.149179e-03 0.0180718955 16 71774519 71774536 18 - 1.829 1.768 -0.204
ENSG00000166747 E049 96.0759241 0.0126047634 2.065878e-04 0.0027468968 16 71774537 71774592 56 - 1.967 1.868 -0.333
ENSG00000166747 E050 84.8763134 0.0057013971 1.574113e-03 0.0141385468 16 71789279 71789319 41 - 1.897 1.870 -0.090
ENSG00000166747 E051 56.4206992 0.0076009726 3.608551e-03 0.0269808028 16 71789320 71789322 3 - 1.726 1.686 -0.136
ENSG00000166747 E052 98.3048157 0.0010615638 2.408112e-05 0.0004475298 16 71789323 71789399 77 - 1.962 1.934 -0.094
ENSG00000166747 E053 76.5848350 0.0009129873 6.700128e-04 0.0071833068 16 71789400 71789480 81 - 1.854 1.843 -0.036
ENSG00000166747 E054 31.8554291 0.1175013767 7.768518e-01 0.8828230332 16 71789481 71789482 2 - 1.472 1.481 0.033
ENSG00000166747 E055 0.8681014 0.1833094363 2.966239e-01   16 71806686 71806728 43 - 0.146 0.414 1.995
ENSG00000166747 E056 1.9877883 0.0108647759 6.287133e-01 0.7896724688 16 71807801 71807838 38 - 0.380 0.557 0.897
ENSG00000166747 E057 1.5223223 0.0553854890 2.372881e-01 0.4734248878 16 71807839 71807906 68 - 0.255 0.559 1.712
ENSG00000166747 E058 0.9748394 0.0322657536 9.253112e-01   16 71807907 71808014 108 - 0.255 0.310 0.380
ENSG00000166747 E059 11.4196145 0.0037903153 4.666503e-01 0.6778224019 16 71808015 71808150 136 - 1.041 1.095 0.197
ENSG00000166747 E060 0.0000000       16 71808151 71808294 144 -      
ENSG00000166747 E061 0.1614157 0.0334296488 9.163048e-01   16 71808357 71808504 148 - 0.079 0.000 -10.827
ENSG00000166747 E062 7.6886905 0.1917678521 8.734142e-01 0.9378450114 16 71808505 71808671 167 - 0.870 0.961 0.345
ENSG00000166747 E063 3.7887295 0.0080112366 4.880202e-01 0.6926732729 16 71808672 71808677 6 - 0.579 0.793 0.899
ENSG00000166747 E064 4.9547945 0.0438930330 4.632543e-01 0.6753099857 16 71808678 71808762 85 - 0.677 0.890 0.850
ENSG00000166747 E065 60.3297669 0.7958339361 6.905218e-01 0.8294183595 16 71808763 71808921 159 - 1.728 1.780 0.177
ENSG00000166747 E066 40.2039306 0.6985229216 9.188058e-01 0.9616174843 16 71808922 71809201 280 - 1.591 1.515 -0.258