ENSG00000166734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299957 ENSG00000166734 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLM2 protein_coding protein_coding 11.50378 2.711733 21.05161 0.5027136 0.3509814 2.952018 6.1390465 1.469568 11.011735 0.3172684 0.2674225 2.897104 0.47910000 0.5340333 0.5232333 -0.0108000 9.787334e-01 5.947865e-08 FALSE TRUE
ENST00000345795 ENSG00000166734 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLM2 protein_coding protein_coding 11.50378 2.711733 21.05161 0.5027136 0.3509814 2.952018 2.9748443 1.065432 5.811776 0.2387937 0.4897008 2.436543 0.24073750 0.3856667 0.2763000 -0.1093667 4.195222e-01 5.947865e-08 FALSE TRUE
ENST00000558847 ENSG00000166734 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLM2 protein_coding protein_coding 11.50378 2.711733 21.05161 0.5027136 0.3509814 2.952018 1.2892757 0.000000 3.344689 0.0000000 0.4457432 8.390035 0.08384583 0.0000000 0.1583000 0.1583000 5.947865e-08 5.947865e-08 FALSE FALSE
ENST00000561305 ENSG00000166734 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLM2 protein_coding protein_coding 11.50378 2.711733 21.05161 0.5027136 0.3509814 2.952018 0.5946795 0.000000 0.000000 0.0000000 0.0000000 0.000000 0.13820000 0.0000000 0.0000000 0.0000000   5.947865e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166734 E001 1.5220326 0.0123455646 0.2624856116 0.50167891 15 44288719 44288728 10 + 0.292 0.515 1.242
ENSG00000166734 E002 1.7000165 0.0127027975 0.3364738025 0.57493155 15 44288729 44288730 2 + 0.322 0.515 1.049
ENSG00000166734 E003 2.3121110 0.0335840396 0.0354057063 0.14264675 15 44288731 44288732 2 + 0.349 0.742 1.870
ENSG00000166734 E004 2.4547456 0.0387180840 0.0516989984 0.18374064 15 44288733 44288737 5 + 0.375 0.741 1.718
ENSG00000166734 E005 3.5706760 0.0070799396 0.0836996494 0.25218933 15 44288738 44288739 2 + 0.505 0.799 1.269
ENSG00000166734 E006 7.9535429 0.0048560864 0.0025502527 0.02065952 15 44288740 44288759 20 + 0.753 1.142 1.463
ENSG00000166734 E007 17.8975144 0.0207903491 0.0003531791 0.00427029 15 44288760 44288904 145 + 1.055 1.468 1.457
ENSG00000166734 E008 47.3773714 0.0347691609 0.2091401776 0.44087200 15 44288905 44289104 200 + 1.520 1.690 0.581
ENSG00000166734 E009 38.3005369 0.0015468295 0.8725838585 0.93735314 15 44289105 44289158 54 + 1.460 1.485 0.084
ENSG00000166734 E010 81.0687313 0.0115520979 0.6356723624 0.79404640 15 44289159 44289356 198 + 1.781 1.760 -0.074
ENSG00000166734 E011 1.6304653 0.0118051190 0.0017256973 0.01520273 15 44307238 44308536 1299 + 0.190 0.744 3.049
ENSG00000166734 E012 0.0000000       15 44319407 44319553 147 +      
ENSG00000166734 E013 53.2751336 0.0287811006 0.5666821593 0.74776929 15 44322965 44323019 55 + 1.607 1.558 -0.169
ENSG00000166734 E014 37.8601291 0.0388108403 0.5434318752 0.73149205 15 44328685 44328699 15 + 1.466 1.406 -0.204
ENSG00000166734 E015 70.8826956 0.0039326333 0.3860596994 0.61734872 15 44328700 44328787 88 + 1.729 1.687 -0.143
ENSG00000166734 E016 82.1506581 0.0006004551 0.4664429352 0.67762270 15 44331988 44332078 91 + 1.790 1.762 -0.094
ENSG00000166734 E017 46.2655355 0.0007890623 0.1535256081 0.36736902 15 44337763 44337763 1 + 1.556 1.463 -0.319
ENSG00000166734 E018 97.7084826 0.0054930179 0.1021440246 0.28560805 15 44337764 44337907 144 + 1.872 1.783 -0.299
ENSG00000166734 E019 71.2417119 0.0154013583 0.3185718461 0.55842556 15 44338237 44338317 81 + 1.734 1.663 -0.242
ENSG00000166734 E020 0.6434498 0.0196197013 0.6399252064   15 44345875 44346149 275 + 0.190 0.000 -9.461
ENSG00000166734 E021 0.1779838 0.0455095007 1.0000000000   15 44348543 44348918 376 + 0.056 0.000 -7.463
ENSG00000166734 E022 83.7365409 0.0006621195 0.6072436920 0.77505730 15 44379690 44379788 99 + 1.799 1.784 -0.051
ENSG00000166734 E023 78.3375498 0.0005952204 0.0879319678 0.25986479 15 44380806 44380863 58 + 1.778 1.695 -0.283
ENSG00000166734 E024 98.1806662 0.0212992729 0.5867213968 0.76140352 15 44380864 44380976 113 + 1.870 1.820 -0.167
ENSG00000166734 E025 0.0000000       15 44382079 44382229 151 +      
ENSG00000166734 E026 46.7658162 0.1983883053 0.6781305058 0.82153644 15 44402887 44403050 164 + 1.546 1.537 -0.031
ENSG00000166734 E027 20.5811783 0.2383945802 0.6326465586 0.79209319 15 44403051 44403054 4 + 1.202 1.222 0.070
ENSG00000166734 E028 1.1364427 0.0143064267 1.0000000000   15 44406330 44406883 554 + 0.261 0.245 -0.119
ENSG00000166734 E029 0.2027342 0.0419242138 0.0689793148   15 44409519 44409847 329 + 0.000 0.246 12.361
ENSG00000166734 E030 67.1493122 1.0368817199 0.5512856299 0.73720790 15 44413336 44413436 101 + 1.689 1.742 0.180
ENSG00000166734 E031 276.8210150 0.0151233561 0.4697706619 0.67988055 15 44413437 44414513 1077 + 2.302 2.334 0.108
ENSG00000166734 E032 264.8907720 0.0146471257 0.6090064245 0.77623557 15 44414514 44415758 1245 + 2.281 2.315 0.115