ENSG00000166689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332954 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding processed_transcript 2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.3646778 0.83768579 0.00000000 0.16933794 0.00000000 -6.40545770 0.12746250 0.24026667 0.00000000 -0.240266667 1.994038e-07 1.994038e-07 FALSE TRUE
ENST00000355661 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding protein_coding 2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.1806174 0.25812483 0.24774984 0.25812483 0.22546520 -0.05693329 0.07778333 0.08756667 0.09323333 0.005666667 8.730847e-01 1.994038e-07 FALSE TRUE
ENST00000530489 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding protein_coding 2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.4241264 0.44786546 0.45192725 0.25258815 0.25411130 0.01274193 0.17105000 0.11910000 0.20363333 0.084533333 9.553734e-01 1.994038e-07 FALSE TRUE
ENST00000531066 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding protein_coding 2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.6415372 0.60931061 0.91076491 0.35614942 0.20820575 0.57216968 0.26899167 0.16820000 0.40630000 0.238100000 6.429477e-01 1.994038e-07 FALSE TRUE
ENST00000533901 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding processed_transcript 2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.1288264 0.07555713 0.21341812 0.03789405 0.10677409 1.38478628 0.05003333 0.02226667 0.08326667 0.061000000 7.260959e-01 1.994038e-07 TRUE FALSE
ENST00000636090 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding protein_coding 2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.1489398 0.15782001 0.20745592 0.15782001 0.20745592 0.37380816 0.05520000 0.05353333 0.07766667 0.024133333 9.867460e-01 1.994038e-07 FALSE TRUE
MSTRG.5217.1 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding   2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.1509831 0.21158907 0.15806706 0.21158907 0.15806706 -0.39884977 0.06185417 0.06426667 0.05916667 -0.005100000 9.801038e-01 1.994038e-07 TRUE TRUE
MSTRG.5217.3 ENSG00000166689 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHA7 protein_coding   2.516594 3.437079 2.337223 0.3327673 0.2361777 -0.5544193 0.3206548 0.48177247 0.02019327 0.28074007 0.02019327 -4.02569185 0.12680833 0.13716667 0.01073333 -0.126433333 6.254990e-01 1.994038e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166689 E001 0.0000000       11 16776290 16776365 76 -      
ENSG00000166689 E002 0.1308682 0.0326491905 7.556629e-01   11 16777297 16777316 20 - 0.000 0.097 9.050
ENSG00000166689 E003 44.7756176 0.0011771913 1.455410e-01 0.3557056726 11 16777317 16778651 1335 - 1.701 1.625 -0.258
ENSG00000166689 E004 12.9247032 0.0031424191 4.124315e-02 0.1579620106 11 16778652 16778884 233 - 1.244 1.053 -0.683
ENSG00000166689 E005 12.0171843 0.0038017375 2.421603e-02 0.1097469967 11 16778885 16779020 136 - 1.223 1.003 -0.794
ENSG00000166689 E006 1.9401545 0.0498868192 3.827567e-02 0.1503223641 11 16780942 16781027 86 - 0.151 0.550 2.619
ENSG00000166689 E007 1.2314435 0.0366428242 1.780494e-01   11 16781028 16781052 25 - 0.151 0.401 1.874
ENSG00000166689 E008 0.4756169 0.0307198017 1.940611e-01   11 16781053 16781204 152 - 0.000 0.244 13.179
ENSG00000166689 E009 12.8878812 0.0143442733 1.663584e-02 0.0841076768 11 16782754 16782896 143 - 1.266 1.013 -0.906
ENSG00000166689 E010 12.2893206 0.0028640164 1.211594e-01 0.3177008522 11 16783700 16783833 134 - 1.201 1.053 -0.531
ENSG00000166689 E011 8.0565719 0.0043813067 3.051629e-01 0.5457735852 11 16786229 16786292 64 - 1.022 0.905 -0.435
ENSG00000166689 E012 10.1733053 0.0033259596 4.330186e-01 0.6535069743 11 16786293 16786387 95 - 1.085 1.002 -0.302
ENSG00000166689 E013 1.3462616 0.0138169880 8.727295e-02   11 16787110 16787237 128 - 0.541 0.244 -1.718
ENSG00000166689 E014 2.7855437 0.6569908511 7.975624e-01 0.8949560755 11 16787484 16787659 176 - 0.538 0.585 0.218
ENSG00000166689 E015 1.7726674 0.0603700506 6.252410e-01 0.7874689834 11 16787660 16787689 30 - 0.488 0.399 -0.461
ENSG00000166689 E016 42.6276135 0.0008727307 1.930832e-05 0.0003712212 11 16787690 16788814 1125 - 1.464 1.706 0.823
ENSG00000166689 E017 13.3524241 0.0220504368 3.558994e-01 0.5924246036 11 16788815 16788982 168 - 1.083 1.185 0.363
ENSG00000166689 E018 7.1833519 0.0042424359 8.638275e-01 0.9325216082 11 16788983 16789095 113 - 0.926 0.905 -0.081
ENSG00000166689 E019 23.3455554 0.0021262654 6.993053e-01 0.8351263190 11 16789096 16789267 172 - 1.368 1.395 0.095
ENSG00000166689 E020 11.6424859 0.0412597071 7.652102e-01 0.8757820675 11 16789268 16789296 29 - 1.081 1.110 0.106
ENSG00000166689 E021 0.6839606 0.0191082734 5.939359e-01   11 16789297 16789774 478 - 0.150 0.244 0.867
ENSG00000166689 E022 19.2791415 0.0024354367 3.195501e-01 0.5593073163 11 16789775 16789869 95 - 1.254 1.334 0.279
ENSG00000166689 E023 9.8240849 0.0033873372 1.093595e-01 0.2980541107 11 16789870 16789878 9 - 0.905 1.081 0.653
ENSG00000166689 E024 2.0029285 0.2197677284 8.291359e-01 0.9133136497 11 16789879 16790797 919 - 0.428 0.482 0.276
ENSG00000166689 E025 20.1654898 0.0017446239 4.161536e-02 0.1589145104 11 16790798 16790915 118 - 1.212 1.373 0.564
ENSG00000166689 E026 20.5523743 0.0020954321 3.170764e-01 0.5570749959 11 16791011 16791170 160 - 1.274 1.350 0.266
ENSG00000166689 E027 9.2833159 0.0042648745 8.635035e-01 0.9323199972 11 16791171 16791199 29 - 0.986 1.003 0.061
ENSG00000166689 E028 5.6703820 0.0218283545 9.159123e-01 0.9601359121 11 16791200 16791202 3 - 0.831 0.814 -0.068
ENSG00000166689 E029 0.1723744 0.0350754310 7.534894e-01   11 16791203 16791345 143 - 0.000 0.098 11.713
ENSG00000166689 E030 0.0000000       11 16791588 16791728 141 -      
ENSG00000166689 E031 12.5790704 0.0663181625 6.345426e-01 0.7932623323 11 16794488 16794637 150 - 1.184 1.086 -0.350
ENSG00000166689 E032 6.9867611 0.0076615357 7.082026e-01 0.8406370174 11 16794638 16794714 77 - 0.926 0.877 -0.187
ENSG00000166689 E033 6.9547856 0.0048130723 4.115003e-01 0.6371987145 11 16794910 16794962 53 - 0.832 0.931 0.381
ENSG00000166689 E034 8.8640327 0.0037154927 1.810841e-01 0.4053815000 11 16794963 16795018 56 - 0.882 1.034 0.567
ENSG00000166689 E035 0.8810853 0.0184979704 5.837141e-02   11 16795019 16795323 305 - 0.000 0.354 13.852
ENSG00000166689 E036 10.1826483 0.0031679461 6.332019e-01 0.7924496434 11 16800974 16801015 42 - 1.004 1.054 0.180
ENSG00000166689 E037 8.5712537 0.0041309422 1.786419e-01 0.4021783628 11 16801016 16801024 9 - 0.858 1.014 0.586
ENSG00000166689 E038 11.6105670 0.0027819487 9.502809e-01 0.9771862614 11 16801025 16801075 51 - 1.085 1.090 0.019
ENSG00000166689 E039 15.6309103 0.0020399946 6.982505e-01 0.8344345598 11 16801668 16801817 150 - 1.234 1.199 -0.122
ENSG00000166689 E040 15.5143816 0.0153047353 1.720153e-01 0.3932170102 11 16802972 16803052 81 - 1.292 1.159 -0.469
ENSG00000166689 E041 13.6358338 0.0096794096 3.794969e-01 0.6118027069 11 16803227 16803295 69 - 1.212 1.130 -0.294
ENSG00000166689 E042 0.4756169 0.0307198017 1.940611e-01   11 16803296 16803533 238 - 0.000 0.244 13.179
ENSG00000166689 E043 0.0000000       11 16807144 16807224 81 -      
ENSG00000166689 E044 0.0000000       11 16812403 16812483 81 -      
ENSG00000166689 E045 11.3829306 0.0030405496 7.087668e-02 0.2264734787 11 16813113 16813166 54 - 1.190 1.013 -0.638
ENSG00000166689 E046 0.0000000       11 16813167 16813315 149 -      
ENSG00000166689 E047 0.1614157 0.0324594054 3.050229e-01   11 16815175 16815294 120 - 0.150 0.000 -13.535
ENSG00000166689 E048 11.5082390 0.0029814989 4.259178e-01 0.6479382645 11 16816178 16816264 87 - 1.141 1.063 -0.282
ENSG00000166689 E049 30.1340695 0.0023573105 9.960673e-01 0.9996639142 11 16816800 16817322 523 - 1.483 1.483 -0.001
ENSG00000166689 E050 0.0000000       11 16817323 16817415 93 -      
ENSG00000166689 E051 30.8341990 0.0340388062 5.551754e-01 0.7399157870 11 16826120 16826590 471 - 1.531 1.462 -0.236
ENSG00000166689 E052 14.6696774 0.0126763815 8.857403e-01 0.9443954076 11 16841547 16841722 176 - 1.191 1.177 -0.048
ENSG00000166689 E053 5.4901305 0.0069361735 2.871656e-01 0.5279463850 11 16851191 16851197 7 - 0.882 0.742 -0.550
ENSG00000166689 E054 9.5997656 0.0578112085 4.222885e-01 0.6453654794 11 16851198 16851291 94 - 1.089 0.962 -0.465
ENSG00000166689 E055 8.9144996 0.0040324428 6.336786e-01 0.7927735405 11 16852283 16852355 73 - 1.022 0.968 -0.198
ENSG00000166689 E056 6.1454311 0.0151751987 4.179138e-01 0.6420714768 11 16854889 16854893 5 - 0.774 0.878 0.406
ENSG00000166689 E057 11.1659638 0.0095757217 6.184586e-01 0.7827666630 11 16854894 16854993 100 - 1.039 1.090 0.188
ENSG00000166689 E058 0.5474829 0.1193237005 2.043731e-01   11 16855619 16855711 93 - 0.000 0.247 13.014
ENSG00000166689 E059 11.3908757 0.0181085589 7.565569e-01 0.8705719832 11 16855803 16855914 112 - 1.055 1.090 0.128
ENSG00000166689 E060 7.6510179 0.0096001685 9.699513e-01 0.9868202671 11 16871099 16871182 84 - 0.926 0.931 0.017
ENSG00000166689 E061 0.1779838 0.0429728783 3.047302e-01   11 16881284 16881619 336 - 0.151 0.000 -13.500
ENSG00000166689 E062 0.0000000       11 16913393 16913484 92 -      
ENSG00000166689 E063 0.1308682 0.0326491905 7.556629e-01   11 17013078 17013342 265 - 0.000 0.097 11.716
ENSG00000166689 E064 5.6908217 0.0132574520 5.661429e-01 0.7474177771 11 17013989 17014046 58 - 0.774 0.847 0.287
ENSG00000166689 E065 0.0000000       11 17014047 17014124 78 -      
ENSG00000166689 E066 4.6300170 0.0675571258 4.410051e-01 0.6594708007 11 17014125 17014142 18 - 0.670 0.782 0.461
ENSG00000166689 E067 5.9350621 0.0295106795 4.795381e-01 0.6868273655 11 17014143 17014201 59 - 0.773 0.864 0.356
ENSG00000166689 E068 3.4953074 0.0564825315 6.322304e-01 0.7918231332 11 17014316 17014416 101 - 0.589 0.660 0.313