ENSG00000166582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299736 ENSG00000166582 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPV protein_coding protein_coding 285.3572 363.2836 169.67 53.72756 7.233688 -1.098319 124.45618 180.95869 50.13011 34.596376 2.3101238 -1.8517029 0.4129500 0.49030000 0.2955333 -0.1947666667 4.130113e-04 6.928418e-11 FALSE TRUE
ENST00000472570 ENSG00000166582 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPV protein_coding retained_intron 285.3572 363.2836 169.67 53.72756 7.233688 -1.098319 101.47696 131.30014 61.53708 18.247127 3.8856737 -1.0932161 0.3348375 0.36260000 0.3620333 -0.0005666667 1.000000e+00 6.928418e-11   FALSE
ENST00000476243 ENSG00000166582 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPV protein_coding nonsense_mediated_decay 285.3572 363.2836 169.67 53.72756 7.233688 -1.098319 24.90775 24.34709 21.55255 2.220849 0.9593092 -0.1758144 0.1044500 0.06940000 0.1275333 0.0581333333 6.076695e-02 6.928418e-11 TRUE TRUE
ENST00000631687 ENSG00000166582 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPV protein_coding processed_transcript 285.3572 363.2836 169.67 53.72756 7.233688 -1.098319 17.27780 13.27105 17.90676 1.606069 0.8215296 0.4319409 0.0721250 0.03716667 0.1055000 0.0683333333 6.928418e-11 6.928418e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166582 E001 0.642642 1.938749e-02 3.401797e-01   17 16340252 16340310 59 - 0.322 0.140 -1.533
ENSG00000166582 E002 4.652158 1.743233e-01 3.015303e-01 5.420257e-01 17 16342534 16342534 1 - 0.574 0.735 0.685
ENSG00000166582 E003 11.314439 9.828598e-03 3.949192e-02 1.534418e-01 17 16342535 16342536 2 - 0.847 1.075 0.852
ENSG00000166582 E004 1863.198518 3.870661e-02 6.038700e-02 2.036804e-01 17 16342537 16342834 298 - 3.125 3.235 0.366
ENSG00000166582 E005 1006.555781 9.144616e-04 5.198073e-05 8.603824e-04 17 16342835 16342841 7 - 2.911 2.953 0.139
ENSG00000166582 E006 975.314275 4.357158e-04 3.039873e-05 5.461704e-04 17 16342842 16342843 2 - 2.905 2.937 0.108
ENSG00000166582 E007 1001.543284 4.427330e-04 5.375544e-05 8.861827e-04 17 16342844 16342845 2 - 2.918 2.948 0.100
ENSG00000166582 E008 1366.203914 8.965306e-05 7.231449e-17 1.406720e-14 17 16342846 16342873 28 - 3.029 3.090 0.203
ENSG00000166582 E009 1683.883409 8.103289e-05 4.634243e-14 6.153253e-12 17 16342874 16342941 68 - 3.133 3.176 0.142
ENSG00000166582 E010 2068.545092 2.140475e-04 4.101218e-09 2.097203e-07 17 16344597 16344711 115 - 3.234 3.262 0.093
ENSG00000166582 E011 13.839513 3.080079e-03 1.679013e-08 7.499606e-07 17 16344712 16344742 31 - 1.445 0.894 -1.976
ENSG00000166582 E012 26.563278 1.952684e-01 1.667180e-04 2.296605e-03 17 16347211 16347315 105 - 1.821 0.991 -2.890
ENSG00000166582 E013 20.362177 1.490216e-01 3.301316e-05 5.857727e-04 17 16347316 16347359 44 - 1.715 0.869 -2.990
ENSG00000166582 E014 12.476944 5.290288e-02 8.741028e-07 2.526255e-05 17 16348037 16348037 1 - 1.485 0.745 -2.696
ENSG00000166582 E015 185.624416 1.174016e-03 8.867647e-50 2.841378e-46 17 16348038 16348474 437 - 2.514 2.023 -1.639
ENSG00000166582 E016 117.820163 9.963289e-03 7.183464e-11 5.235697e-09 17 16348475 16348573 99 - 2.286 1.861 -1.423
ENSG00000166582 E017 99.235286 2.040107e-02 9.771632e-06 2.055044e-04 17 16348574 16348615 42 - 2.199 1.801 -1.334
ENSG00000166582 E018 1361.576024 4.035394e-04 8.559649e-03 5.187873e-02 17 16348616 16348685 70 - 3.072 3.074 0.008
ENSG00000166582 E019 529.245291 1.649303e-02 9.054238e-06 1.926598e-04 17 16348686 16349023 338 - 2.882 2.555 -1.089
ENSG00000166582 E020 444.713212 1.253238e-02 1.849898e-13 2.181634e-11 17 16349024 16349139 116 - 2.875 2.422 -1.509
ENSG00000166582 E021 555.451619 1.588681e-02 2.180858e-11 1.772905e-09 17 16349140 16349333 194 - 2.972 2.518 -1.510
ENSG00000166582 E022 23.501858 1.316129e-01 1.631864e-02 8.296499e-02 17 16349334 16349349 16 - 1.626 1.156 -1.629
ENSG00000166582 E023 17.286641 2.393330e-01 3.387032e-02 1.385147e-01 17 16349350 16349356 7 - 1.524 1.007 -1.822
ENSG00000166582 E024 51.855072 1.042174e-01 2.231264e-03 1.859646e-02 17 16349502 16349713 212 - 1.985 1.460 -1.780
ENSG00000166582 E025 44.186448 9.859815e-02 5.250627e-03 3.594603e-02 17 16349714 16349930 217 - 1.889 1.419 -1.599
ENSG00000166582 E026 1507.229484 3.308754e-03 8.991210e-01 9.514111e-01 17 16349931 16350029 99 - 3.136 3.111 -0.085
ENSG00000166582 E027 1273.955626 9.658853e-03 2.164431e-02 1.014294e-01 17 16353027 16353480 454 - 2.984 3.063 0.264
ENSG00000166582 E028 1.195805 4.485057e-02 2.032721e-01   17 16353628 16353656 29 - 0.503 0.245 -1.530