ENSG00000166452

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299576 ENSG00000166452 HEK293_OSMI2_6hA HEK293_TMG_6hB AKIP1 protein_coding protein_coding 22.14758 25.77703 12.97372 5.029757 0.2665957 -0.9899419 2.077952 4.408093 3.5467060 1.0108868 0.5989052 -0.3128822 0.1045167 0.1683667 0.27523333 0.10686667 4.677895e-01 7.594896e-26 FALSE TRUE
ENST00000309377 ENSG00000166452 HEK293_OSMI2_6hA HEK293_TMG_6hB AKIP1 protein_coding protein_coding 22.14758 25.77703 12.97372 5.029757 0.2665957 -0.9899419 9.798858 10.206723 4.7013537 2.4057260 0.6136096 -1.1167189 0.4460083 0.3939667 0.36106667 -0.03290000 9.174064e-01 7.594896e-26 FALSE TRUE
ENST00000396648 ENSG00000166452 HEK293_OSMI2_6hA HEK293_TMG_6hB AKIP1 protein_coding protein_coding 22.14758 25.77703 12.97372 5.029757 0.2665957 -0.9899419 4.585894 4.732431 0.0000000 0.9614773 0.0000000 -8.8894830 0.1844833 0.1828333 0.00000000 -0.18283333 7.594896e-26 7.594896e-26 FALSE TRUE
ENST00000525005 ENSG00000166452 HEK293_OSMI2_6hA HEK293_TMG_6hB AKIP1 protein_coding protein_coding 22.14758 25.77703 12.97372 5.029757 0.2665957 -0.9899419 1.014855 0.838540 0.7252877 0.5094734 0.5248316 -0.2066739 0.0500625 0.0435000 0.05666667 0.01316667 1.000000e+00 7.594896e-26 FALSE TRUE
MSTRG.5129.2 ENSG00000166452 HEK293_OSMI2_6hA HEK293_TMG_6hB AKIP1 protein_coding   22.14758 25.77703 12.97372 5.029757 0.2665957 -0.9899419 2.442471 3.415627 1.9826279 0.9733499 0.6328214 -0.7816958 0.1112958 0.1274333 0.15100000 0.02356667 9.591616e-01 7.594896e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166452 E001 0.869939 0.0242552963 1.302750e-01   11 8911117 8911124 8 + 0.000 0.308 9.889
ENSG00000166452 E002 1.537331 0.0121989077 1.941808e-01 4.223589e-01 11 8911125 8911138 14 + 0.178 0.423 1.709
ENSG00000166452 E003 3.435810 0.0163307811 9.770503e-02 2.777695e-01 11 8911139 8911153 15 + 0.400 0.690 1.364
ENSG00000166452 E004 4.672386 0.0267937288 5.386794e-01 7.281014e-01 11 8911154 8911188 35 + 0.656 0.755 0.410
ENSG00000166452 E005 5.933899 0.0197297363 9.972063e-01 1.000000e+00 11 8911189 8911191 3 + 0.816 0.814 -0.008
ENSG00000166452 E006 7.313110 0.0465208782 5.102723e-01 7.081796e-01 11 8911192 8911198 7 + 0.957 0.862 -0.361
ENSG00000166452 E007 22.474975 0.0020873058 3.635868e-02 1.452150e-01 11 8911199 8911214 16 + 1.443 1.277 -0.578
ENSG00000166452 E008 37.758601 0.0024921388 1.550218e-01 3.695019e-01 11 8911215 8911223 9 + 1.611 1.515 -0.328
ENSG00000166452 E009 5.658111 0.0123781723 3.566364e-01 5.930806e-01 11 8911224 8911287 64 + 0.702 0.829 0.511
ENSG00000166452 E010 23.331825 0.0019275687 8.637894e-02 2.571772e-01 11 8911288 8911337 50 + 1.247 1.378 0.458
ENSG00000166452 E011 24.755164 0.0019081177 3.228929e-02 1.340897e-01 11 8911338 8911354 17 + 1.247 1.410 0.570
ENSG00000166452 E012 35.846565 0.0012535867 2.779556e-03 2.205554e-02 11 8911355 8911442 88 + 1.375 1.571 0.674
ENSG00000166452 E013 20.878095 0.0020957970 8.487433e-02 2.543743e-01 11 8911443 8911443 1 + 1.194 1.334 0.492
ENSG00000166452 E014 79.265017 0.0006402032 3.416511e-01 5.794720e-01 11 8911444 8911464 21 + 1.894 1.845 -0.162
ENSG00000166452 E015 139.608950 0.0004539912 3.537247e-01 5.905891e-01 11 8911465 8911614 150 + 2.085 2.107 0.074
ENSG00000166452 E016 97.732359 0.0008364285 2.128058e-02 1.002488e-01 11 8911615 8911671 57 + 1.885 1.971 0.289
ENSG00000166452 E017 55.153343 0.0009745713 9.423801e-01 9.734558e-01 11 8912453 8912533 81 + 1.707 1.695 -0.043
ENSG00000166452 E018 148.466770 0.0004282908 2.741940e-01 5.141663e-01 11 8914826 8914930 105 + 2.155 2.113 -0.139
ENSG00000166452 E019 118.010223 0.0004445434 9.994418e-01 1.000000e+00 11 8917287 8917367 81 + 2.032 2.023 -0.029
ENSG00000166452 E020 22.474129 0.0329036440 2.921097e-07 9.624940e-06 11 8917368 8918119 752 + 1.652 1.072 -2.024
ENSG00000166452 E021 336.368571 0.0048659111 9.387812e-01 9.716752e-01 11 8919337 8920084 748 + 2.485 2.479 -0.019