ENSG00000166398

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299505 ENSG00000166398 HEK293_OSMI2_6hA HEK293_TMG_6hB GARRE1 protein_coding protein_coding 4.261794 3.336045 5.414266 0.4725052 0.2980406 0.696971 3.3107746 2.3364849 4.9312865 0.38617825 0.28488333 1.0743856 0.72547083 0.69493333 0.91123333 0.216300000 0.03241711 0.03241711 FALSE TRUE
ENST00000588338 ENSG00000166398 HEK293_OSMI2_6hA HEK293_TMG_6hB GARRE1 protein_coding processed_transcript 4.261794 3.336045 5.414266 0.4725052 0.2980406 0.696971 0.2114312 0.1327421 0.0000000 0.13274210 0.00000000 -3.8353390 0.05801250 0.03423333 0.00000000 -0.034233333 0.81038720 0.03241711   FALSE
ENST00000588974 ENSG00000166398 HEK293_OSMI2_6hA HEK293_TMG_6hB GARRE1 protein_coding retained_intron 4.261794 3.336045 5.414266 0.4725052 0.2980406 0.696971 0.2542005 0.1701811 0.2760526 0.05378747 0.07561672 0.6668327 0.07332917 0.05860000 0.05013333 -0.008466667 1.00000000 0.03241711 FALSE TRUE
MSTRG.16948.1 ENSG00000166398 HEK293_OSMI2_6hA HEK293_TMG_6hB GARRE1 protein_coding   4.261794 3.336045 5.414266 0.4725052 0.2980406 0.696971 0.1933086 0.3718834 0.0000000 0.18597292 0.00000000 -5.2550605 0.06229167 0.12530000 0.00000000 -0.125300000 0.28307344 0.03241711 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166398 E001 0.0000000       19 34254552 34254553 2 +      
ENSG00000166398 E002 1.6009132 0.011406794 0.797350548 0.89479520 19 34254554 34254579 26 + 0.417 0.406 -0.060
ENSG00000166398 E003 2.4470973 0.009155673 0.406003976 0.63306178 19 34254580 34254580 1 + 0.567 0.468 -0.474
ENSG00000166398 E004 5.4986544 0.005815165 0.501938117 0.70215127 19 34254581 34254596 16 + 0.823 0.781 -0.166
ENSG00000166398 E005 9.5859583 0.013263136 0.329118638 0.56813428 19 34254597 34254614 18 + 1.040 0.979 -0.223
ENSG00000166398 E006 0.0000000       19 34265558 34265567 10 +      
ENSG00000166398 E007 0.0000000       19 34265568 34265621 54 +      
ENSG00000166398 E008 0.1779838 0.064389476 0.600412225   19 34285150 34285170 21 + 0.104 0.000 -8.576
ENSG00000166398 E009 0.3206185 0.024840016 0.274117654   19 34285171 34285273 103 + 0.187 0.000 -9.573
ENSG00000166398 E010 32.1012812 0.024416267 0.016188261 0.08248490 19 34299679 34299923 245 + 1.576 1.409 -0.574
ENSG00000166398 E011 37.6750182 0.023637431 0.015801484 0.08109076 19 34299924 34300264 341 + 1.639 1.483 -0.533
ENSG00000166398 E012 59.8821177 0.010989368 0.005002223 0.03464077 19 34300265 34300754 490 + 1.830 1.704 -0.427
ENSG00000166398 E013 40.7774609 0.016437470 0.058416182 0.19923705 19 34300755 34300968 214 + 1.649 1.557 -0.312
ENSG00000166398 E014 24.8422696 0.021385137 0.120827186 0.31715409 19 34319907 34319972 66 + 1.437 1.346 -0.314
ENSG00000166398 E015 33.6689732 0.045011777 0.190720253 0.41781070 19 34319973 34320116 144 + 1.560 1.481 -0.270
ENSG00000166398 E016 31.4978692 0.001529928 0.001035250 0.01017474 19 34327421 34327561 141 + 1.568 1.411 -0.540
ENSG00000166398 E017 26.8599188 0.003659181 0.006792762 0.04366596 19 34327771 34327866 96 + 1.496 1.355 -0.488
ENSG00000166398 E018 35.0946560 0.009416169 0.436471987 0.65611817 19 34327990 34328151 162 + 1.549 1.548 -0.004
ENSG00000166398 E019 36.7355574 0.006032794 0.054064011 0.18922738 19 34330189 34330347 159 + 1.601 1.530 -0.245
ENSG00000166398 E020 30.1348287 0.005220414 0.130158220 0.33208129 19 34333704 34333801 98 + 1.517 1.464 -0.182
ENSG00000166398 E021 32.1468794 0.001568090 0.923069690 0.96381338 19 34339867 34339992 126 + 1.503 1.549 0.157
ENSG00000166398 E022 118.4883494 1.256441269 0.496341121 0.69843615 19 34341422 34342455 1034 + 1.991 2.164 0.581
ENSG00000166398 E023 28.5741075 0.001537993 0.017789363 0.08832414 19 34347877 34348042 166 + 1.372 1.577 0.704
ENSG00000166398 E024 6.4246631 0.056855557 0.442776663 0.66058440 19 34348462 34349015 554 + 0.899 0.812 -0.333
ENSG00000166398 E025 28.7928811 0.001512656 0.074000979 0.23278815 19 34349016 34349119 104 + 1.392 1.559 0.575
ENSG00000166398 E026 21.4889341 0.001886507 0.035209874 0.14213089 19 34349120 34349153 34 + 1.253 1.460 0.719
ENSG00000166398 E027 25.6258536 0.006769951 0.056072535 0.19381665 19 34351514 34351592 79 + 1.326 1.529 0.701
ENSG00000166398 E028 260.1215405 0.023052852 0.008266743 0.05055213 19 34352647 34355566 2920 + 2.317 2.516 0.664