ENSG00000166263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376352 ENSG00000166263 HEK293_OSMI2_6hA HEK293_TMG_6hB STXBP4 protein_coding protein_coding 3.743553 1.014387 8.06934 0.101339 1.319989 2.979477 0.94971772 0.55722506 1.9080043 0.13532842 0.03314676 1.757613 0.38197917 0.56216667 0.24676667 -0.31540000 0.372873487 0.005621221 FALSE TRUE
ENST00000405898 ENSG00000166263 HEK293_OSMI2_6hA HEK293_TMG_6hB STXBP4 protein_coding protein_coding 3.743553 1.014387 8.06934 0.101339 1.319989 2.979477 0.16777981 0.01452922 0.2484973 0.01452922 0.12969603 3.397576 0.07886667 0.01203333 0.02940000 0.01736667 0.948204812 0.005621221 FALSE TRUE
ENST00000461444 ENSG00000166263 HEK293_OSMI2_6hA HEK293_TMG_6hB STXBP4 protein_coding retained_intron 3.743553 1.014387 8.06934 0.101339 1.319989 2.979477 0.51427827 0.13656517 1.0371909 0.13656517 1.03719091 2.836910 0.12099167 0.14053333 0.09700000 -0.04353333 0.905223832 0.005621221   FALSE
ENST00000463234 ENSG00000166263 HEK293_OSMI2_6hA HEK293_TMG_6hB STXBP4 protein_coding protein_coding 3.743553 1.014387 8.06934 0.101339 1.319989 2.979477 0.04471552 0.07601703 0.0000000 0.07601703 0.00000000 -3.104622 0.02353750 0.06296667 0.00000000 -0.06296667 0.506806210 0.005621221   FALSE
MSTRG.14710.1 ENSG00000166263 HEK293_OSMI2_6hA HEK293_TMG_6hB STXBP4 protein_coding   3.743553 1.014387 8.06934 0.101339 1.319989 2.979477 0.24485237 0.13076994 0.3245121 0.08701289 0.10240956 1.248719 0.07356250 0.11890000 0.04586667 -0.07303333 0.796694993 0.005621221 TRUE TRUE
MSTRG.14710.3 ENSG00000166263 HEK293_OSMI2_6hA HEK293_TMG_6hB STXBP4 protein_coding   3.743553 1.014387 8.06934 0.101339 1.319989 2.979477 1.72422429 0.04426773 4.3977313 0.04426773 0.32937512 6.343798 0.29247500 0.04556667 0.55956667 0.51400000 0.005621221 0.005621221 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166263 E001 1.8378495 0.013098997 8.887416e-01 9.460304e-01 17 54968727 54968764 38 + 0.368 0.408 0.223
ENSG00000166263 E002 3.0931565 0.058843103 7.910795e-01 8.910941e-01 17 54968765 54968774 10 + 0.511 0.524 0.060
ENSG00000166263 E003 3.2545722 0.037280579 6.860452e-01 8.265380e-01 17 54968775 54968775 1 + 0.530 0.524 -0.029
ENSG00000166263 E004 7.0596640 0.038645714 4.998419e-01 7.006285e-01 17 54968776 54968791 16 + 0.790 0.755 -0.140
ENSG00000166263 E005 7.2101210 0.019387736 2.108194e-01 4.427635e-01 17 54968792 54968794 3 + 0.809 0.690 -0.483
ENSG00000166263 E006 10.2016015 0.026877931 1.613493e-01 3.787522e-01 17 54968795 54968815 21 + 0.939 0.810 -0.494
ENSG00000166263 E007 16.2904536 0.019546506 9.051582e-01 9.546138e-01 17 54985614 54985691 78 + 1.093 1.176 0.299
ENSG00000166263 E008 22.6105794 0.017219719 2.153593e-01 4.479182e-01 17 54986142 54986266 125 + 1.242 1.199 -0.151
ENSG00000166263 E009 27.8375707 0.001391695 6.253587e-02 2.084689e-01 17 54990825 54990957 133 + 1.331 1.277 -0.191
ENSG00000166263 E010 0.0000000       17 54990958 54990988 31 +      
ENSG00000166263 E011 0.3206185 0.027442404 1.000000e+00   17 54991039 54991852 814 + 0.103 0.000 -11.055
ENSG00000166263 E012 29.2534561 0.001401904 8.932067e-03 5.351079e-02 17 54999345 54999451 107 + 1.362 1.239 -0.431
ENSG00000166263 E013 0.1779838 0.035708007 1.000000e+00   17 54999626 54999631 6 + 0.055 0.000 -10.079
ENSG00000166263 E014 41.6803237 0.001840578 1.975206e-05 3.782964e-04 17 54999632 54999815 184 + 1.516 1.276 -0.830
ENSG00000166263 E015 18.4861632 0.047579135 1.565199e-01 3.715915e-01 17 54999816 54999842 27 + 1.164 1.045 -0.431
ENSG00000166263 E016 24.2575082 0.001825226 5.445227e-02 1.901474e-01 17 55000808 55000883 76 + 1.274 1.198 -0.265
ENSG00000166263 E017 25.2953869 0.001395172 7.542256e-03 4.722815e-02 17 55007506 55007597 92 + 1.303 1.153 -0.529
ENSG00000166263 E018 0.0000000       17 55030807 55031167 361 +      
ENSG00000166263 E019 26.0373095 0.008623465 1.212732e-01 3.178728e-01 17 55031168 55031264 97 + 1.304 1.258 -0.163
ENSG00000166263 E020 23.3310332 0.024611955 3.339955e-01 5.725392e-01 17 55034168 55034259 92 + 1.252 1.239 -0.045
ENSG00000166263 E021 24.2147743 0.001684133 1.334516e-01 3.372091e-01 17 55043236 55043325 90 + 1.270 1.239 -0.108
ENSG00000166263 E022 0.1779838 0.035708007 1.000000e+00   17 55043326 55043375 50 + 0.055 0.000 -10.079
ENSG00000166263 E023 6.2483600 0.081696098 5.197754e-01 7.148811e-01 17 55043612 55044776 1165 + 0.699 0.906 0.820
ENSG00000166263 E024 24.2650305 0.001711380 1.228873e-01 3.202961e-01 17 55047089 55047154 66 + 1.273 1.239 -0.119
ENSG00000166263 E025 32.4842042 0.001264133 2.405842e-01 4.772482e-01 17 55072900 55073076 177 + 1.382 1.400 0.064
ENSG00000166263 E026 21.1998782 0.001581266 3.201780e-01 5.598834e-01 17 55078078 55078194 117 + 1.207 1.220 0.045
ENSG00000166263 E027 14.7432901 0.002301623 5.830309e-01 7.590316e-01 17 55078686 55078735 50 + 1.058 1.103 0.165
ENSG00000166263 E028 26.7085750 0.001347485 1.011813e-01 2.839307e-01 17 55081050 55081183 134 + 1.312 1.277 -0.123
ENSG00000166263 E029 24.1695064 0.001614924 5.291560e-02 1.865149e-01 17 55141310 55141367 58 + 1.274 1.198 -0.265
ENSG00000166263 E030 33.6974984 0.007260904 8.718587e-03 5.256378e-02 17 55159797 55159946 150 + 1.413 1.277 -0.473
ENSG00000166263 E031 24.0718424 0.001619143 2.252267e-03 1.874751e-02 17 55159947 55160050 104 + 1.283 1.076 -0.737
ENSG00000166263 E032 396.0220030 0.010822413 1.556127e-09 8.747638e-08 17 55160051 55173632 13582 + 2.391 2.695 1.014
ENSG00000166263 E033 1.1384679 0.015722786 5.159899e-01   17 55175859 55176069 211 + 0.222 0.408 1.221
ENSG00000166263 E034 0.3040503 0.027442404 1.000000e+00   17 55201588 55201708 121 + 0.103 0.000 -11.054