ENSG00000166200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299259 ENSG00000166200 HEK293_OSMI2_6hA HEK293_TMG_6hB COPS2 protein_coding protein_coding 35.90644 5.974898 69.63047 1.074906 2.857185 3.540527 22.426552 4.2479780 41.129395 0.7248363 2.0775659 3.272280 0.68050000 0.71373333 0.59066667 -0.12306667 0.0669990156 0.0002181468 FALSE TRUE
ENST00000388901 ENSG00000166200 HEK293_OSMI2_6hA HEK293_TMG_6hB COPS2 protein_coding protein_coding 35.90644 5.974898 69.63047 1.074906 2.857185 3.540527 2.530114 0.3083864 4.727531 0.0422672 0.0459424 3.895285 0.07634167 0.05256667 0.06806667 0.01550000 0.7202345682 0.0002181468 FALSE TRUE
ENST00000558843 ENSG00000166200 HEK293_OSMI2_6hA HEK293_TMG_6hB COPS2 protein_coding protein_coding 35.90644 5.974898 69.63047 1.074906 2.857185 3.540527 7.380977 0.9400371 14.863782 0.2858549 0.1915790 3.968644 0.15461667 0.15126667 0.21410000 0.06283333 0.4955237856 0.0002181468 FALSE TRUE
MSTRG.10771.5 ENSG00000166200 HEK293_OSMI2_6hA HEK293_TMG_6hB COPS2 protein_coding   35.90644 5.974898 69.63047 1.074906 2.857185 3.540527 2.000743 0.0000000 5.025683 0.0000000 1.3243562 8.976044 0.03058333 0.00000000 0.07346667 0.07346667 0.0002181468 0.0002181468 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166200 E001 2.3522458 0.0111259738 0.0000235123 0.0004385907 15 49106068 49106320 253 - 0.237 0.955 3.467
ENSG00000166200 E002 0.7459833 0.5866119013 0.1783977867   15 49119045 49119167 123 - 0.118 0.462 2.598
ENSG00000166200 E003 264.6920345 0.0009808390 0.0055125827 0.0372854600 15 49122727 49127349 4623 - 2.204 2.092 -0.376
ENSG00000166200 E004 121.6085844 0.0007175222 0.0113877777 0.0639540516 15 49127350 49127535 186 - 1.848 1.975 0.427
ENSG00000166200 E005 151.4773686 0.0011606666 0.0014585608 0.0133249323 15 49127536 49127658 123 - 1.940 2.085 0.485
ENSG00000166200 E006 447.6541316 0.0002351933 0.0889904396 0.2619126778 15 49127659 49128094 436 - 2.420 2.465 0.152
ENSG00000166200 E007 140.6591733 0.0006039651 0.2316409503 0.4670302874 15 49128702 49128760 59 - 1.921 1.979 0.196
ENSG00000166200 E008 175.7385937 0.0002841175 0.4511577064 0.6664720045 15 49129477 49129559 83 - 2.017 2.051 0.112
ENSG00000166200 E009 230.5268270 0.0002001822 0.3790832645 0.6114828047 15 49130719 49130816 98 - 2.139 2.106 -0.113
ENSG00000166200 E010 193.8146139 0.0003025479 0.8657739606 0.9336199141 15 49133759 49133811 53 - 2.062 2.070 0.026
ENSG00000166200 E011 246.3959208 0.0002059123 0.3350006161 0.5735712303 15 49133930 49134032 103 - 2.168 2.132 -0.120
ENSG00000166200 E012 182.6142608 0.0002402051 0.5018905519 0.7021324414 15 49134033 49134082 50 - 2.039 2.010 -0.096
ENSG00000166200 E013 148.9663168 0.0003814148 0.2563217446 0.4951046975 15 49134083 49134108 26 - 1.955 1.899 -0.188
ENSG00000166200 E014 0.2922838 0.0260109664 0.1028080036   15 49134135 49134339 205 - 0.043 0.302 3.274
ENSG00000166200 E015 275.1233306 0.0002145541 0.7694319990 0.8782924408 15 49134340 49134514 175 - 2.215 2.206 -0.031
ENSG00000166200 E016 185.3580739 0.0002888697 0.7457386919 0.8641604756 15 49137150 49137227 78 - 2.040 2.055 0.050
ENSG00000166200 E017 178.4834431 0.0003046817 0.7487797303 0.8659767103 15 49137348 49137422 75 - 2.024 2.039 0.051
ENSG00000166200 E018 101.1491593 0.0004333249 0.5299946607 0.7220826369 15 49137423 49137437 15 - 1.786 1.750 -0.123
ENSG00000166200 E019 43.3168964 0.0008706147 0.9028312401 0.9532657496 15 49137438 49137458 21 - 1.422 1.433 0.040
ENSG00000166200 E020 0.4654660 0.0296955297 1.0000000000   15 49137459 49137459 1 - 0.118 0.001 -7.030
ENSG00000166200 E021 1.8553275 0.5692106530 0.3327684445 0.5714374537 15 49139258 49139527 270 - 0.259 0.632 2.005
ENSG00000166200 E022 182.9972825 0.0002478486 0.1284649905 0.3294320801 15 49139528 49139653 126 - 2.043 1.975 -0.227
ENSG00000166200 E023 198.5315393 0.0002483441 0.0623359244 0.2080228280 15 49144227 49144304 78 - 2.078 1.997 -0.270
ENSG00000166200 E024 221.1090762 0.0008992362 0.5033284152 0.7030898427 15 49144965 49145078 114 - 2.119 2.092 -0.091
ENSG00000166200 E025 147.4484845 0.0022845273 0.7814407727 0.8855059365 15 49155525 49155661 137 - 1.940 1.956 0.054