ENSG00000166181

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378852 ENSG00000166181 HEK293_OSMI2_6hA HEK293_TMG_6hB API5 protein_coding protein_coding 63.42315 18.41533 110.6573 5.821169 5.278433 2.586466 21.171832 7.1555230 40.03105060 2.2643359 2.76833651 2.482336 0.33303750 0.40256667 0.3621000000 -0.04046667 8.921705e-01 6.636254e-07 FALSE TRUE
ENST00000531273 ENSG00000166181 HEK293_OSMI2_6hA HEK293_TMG_6hB API5 protein_coding protein_coding 63.42315 18.41533 110.6573 5.821169 5.278433 2.586466 24.210007 8.8094642 43.86689254 3.1800129 3.64336642 2.314698 0.39003333 0.45540000 0.3964666667 -0.05893333 7.856428e-01 6.636254e-07 FALSE TRUE
ENST00000534695 ENSG00000166181 HEK293_OSMI2_6hA HEK293_TMG_6hB API5 protein_coding protein_coding 63.42315 18.41533 110.6573 5.821169 5.278433 2.586466 1.968647 0.3192934 0.03196822 0.3192934 0.03196822 -2.972004 0.07704583 0.01296667 0.0002666667 -0.01270000 7.801556e-01 6.636254e-07 FALSE TRUE
MSTRG.5398.3 ENSG00000166181 HEK293_OSMI2_6hA HEK293_TMG_6hB API5 protein_coding   63.42315 18.41533 110.6573 5.821169 5.278433 2.586466 5.610239 0.0000000 8.63672574 0.0000000 2.77048711 9.756010 0.05335000 0.00000000 0.0761000000 0.07610000 6.636254e-07 6.636254e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166181 E001 0.1614157 0.0359150607 1.000000000   11 43311963 43311966 4 + 0.057 0.000 -9.573
ENSG00000166181 E002 0.1614157 0.0359150607 1.000000000   11 43311967 43311967 1 + 0.057 0.000 -9.564
ENSG00000166181 E003 2.6143101 0.0100839732 0.919475179 0.96198419 11 43311968 43311977 10 + 0.451 0.509 0.291
ENSG00000166181 E004 7.8802712 0.0469326405 0.389389588 0.61998226 11 43311978 43311988 11 + 0.841 0.739 -0.405
ENSG00000166181 E005 13.3173053 0.0237810097 0.499272165 0.70032579 11 43311989 43311995 7 + 1.036 0.997 -0.142
ENSG00000166181 E006 16.5051747 0.0147205197 0.215907757 0.44852032 11 43311996 43311997 2 + 1.130 1.029 -0.368
ENSG00000166181 E007 24.8224101 0.0092034516 0.060245250 0.20337188 11 43311998 43312002 5 + 1.303 1.158 -0.509
ENSG00000166181 E008 171.2861308 0.0072190402 0.882784747 0.94276610 11 43312003 43312095 93 + 2.094 2.161 0.224
ENSG00000166181 E009 266.7301549 0.0084647266 0.942806021 0.97369897 11 43312096 43312196 101 + 2.287 2.338 0.172
ENSG00000166181 E010 14.1069536 0.0724546010 0.654751762 0.80656841 11 43318421 43318482 62 + 1.057 1.028 -0.107
ENSG00000166181 E011 387.9448084 0.0066365989 0.520322829 0.71514069 11 43318640 43318801 162 + 2.453 2.486 0.112
ENSG00000166181 E012 0.0000000       11 43318802 43318984 183 +      
ENSG00000166181 E013 360.3297146 0.0059844886 0.080085301 0.24500446 11 43320821 43320914 94 + 2.430 2.414 -0.051
ENSG00000166181 E014 322.3672883 0.0102796200 0.035973266 0.14415026 11 43321411 43321476 66 + 2.387 2.334 -0.177
ENSG00000166181 E015 326.7905654 0.0096291323 0.007524618 0.04714226 11 43321985 43322043 59 + 2.396 2.313 -0.278
ENSG00000166181 E016 342.8484388 0.0084209447 0.003930925 0.02875932 11 43322044 43322136 93 + 2.417 2.331 -0.285
ENSG00000166181 E017 581.1335021 0.0071374221 0.007798545 0.04837536 11 43323430 43323636 207 + 2.641 2.589 -0.171
ENSG00000166181 E018 392.1236272 0.0021017915 0.016822204 0.08481169 11 43326507 43326611 105 + 2.465 2.451 -0.048
ENSG00000166181 E019 370.4912232 0.0103212391 0.868745279 0.93523845 11 43327789 43327878 90 + 2.430 2.482 0.175
ENSG00000166181 E020 420.5299783 0.2685959109 0.345318109 0.58287404 11 43328712 43328893 182 + 2.466 2.607 0.469
ENSG00000166181 E021 202.2359772 0.3603610878 0.316391193 0.55642281 11 43329965 43329985 21 + 2.145 2.310 0.551
ENSG00000166181 E022 284.7743400 0.1698668040 0.300164851 0.54059903 11 43329986 43330058 73 + 2.298 2.439 0.472
ENSG00000166181 E023 15.5905009 0.0525507787 0.517799641 0.71345955 11 43330233 43330507 275 + 1.102 1.035 -0.241
ENSG00000166181 E024 230.4656550 0.1740872958 0.337667962 0.57604012 11 43330508 43330564 57 + 2.208 2.341 0.442
ENSG00000166181 E025 138.3255013 1.4558342784 0.528382881 0.72088207 11 43335278 43335278 1 + 1.982 2.142 0.537
ENSG00000166181 E026 276.3684502 0.2159648425 0.285622404 0.52621959 11 43335279 43335354 76 + 2.283 2.434 0.504
ENSG00000166181 E027 383.8353099 0.0143967449 0.668989237 0.81554057 11 43335858 43335994 137 + 2.444 2.502 0.194
ENSG00000166181 E028 16.7687780 0.0181860464 0.419760262 0.64348210 11 43335995 43336230 236 + 1.093 1.241 0.530
ENSG00000166181 E029 23.7861630 0.0099696528 0.282851054 0.52329794 11 43339241 43339497 257 + 1.278 1.219 -0.206
ENSG00000166181 E030 5.2829568 0.3240332999 0.756587693 0.87058127 11 43340224 43340226 3 + 0.671 0.791 0.492
ENSG00000166181 E031 113.6120748 0.0003513759 0.119924588 0.31573522 11 43342428 43342432 5 + 1.935 1.925 -0.033
ENSG00000166181 E032 346.8304341 0.0008783636 0.111037826 0.30067890 11 43342433 43342515 83 + 2.410 2.427 0.058
ENSG00000166181 E033 2421.7770097 0.0260767127 0.608305446 0.77580382 11 43342516 43344529 2014 + 3.231 3.344 0.373
ENSG00000166181 E034 0.1426347 0.0337356802 1.000000000   11 43364830 43364878 49 + 0.057 0.000 -9.562