ENSG00000166140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355341 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding protein_coding 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 4.238025 6.526921 2.4529458 0.4372602 0.1734797 -1.4082263 0.21344583 0.23583333 0.19120000 -0.044633333 5.318979e-01 4.78327e-13 FALSE TRUE
ENST00000560078 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding retained_intron 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 2.275672 2.760620 2.1527392 0.4615390 0.1254791 -0.3573491 0.12290417 0.10133333 0.16836667 0.067033333 3.486966e-01 4.78327e-13 FALSE TRUE
ENST00000566407 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding protein_coding 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 1.415494 1.535152 0.9551711 0.9132939 0.5489601 -0.6788923 0.07751667 0.05703333 0.07643333 0.019400000 9.862126e-01 4.78327e-13 FALSE FALSE
ENST00000566767 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding protein_coding 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 2.139689 2.796704 1.3945117 0.4325987 0.7022619 -0.9988082 0.11104583 0.09970000 0.10583333 0.006133333 9.493075e-01 4.78327e-13   FALSE
ENST00000567756 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding nonsense_mediated_decay 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 1.164910 3.051242 0.0000000 0.7772275 0.0000000 -8.2579734 0.05514583 0.10630000 0.00000000 -0.106300000 4.783270e-13 4.78327e-13 FALSE FALSE
ENST00000569057 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding nonsense_mediated_decay 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 2.368824 2.529900 1.9164620 0.6055659 0.1496913 -0.3988177 0.12369167 0.08883333 0.15143333 0.062600000 3.626131e-01 4.78327e-13 FALSE TRUE
ENST00000570162 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding retained_intron 19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 1.303920 1.063798 1.8259096 0.4076609 0.1353301 0.7737722 0.07714167 0.03726667 0.14233333 0.105066667 7.280353e-02 4.78327e-13 FALSE FALSE
MSTRG.10580.12 ENSG00000166140 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE19 protein_coding   19.54143 27.88 12.79886 2.914235 0.5936716 -1.122606 3.247766 4.921476 1.5737185 1.0077350 0.1754303 -1.6387037 0.15713750 0.17576667 0.12470000 -0.051066667 7.371880e-01 4.78327e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166140 E001 4.883808 0.0058806281 9.169026e-01 0.9606462267 15 40807086 40807088 3 + 0.743 0.717 -0.106
ENSG00000166140 E002 46.715956 0.0008559058 2.913869e-01 0.5319794161 15 40807089 40807233 145 + 1.671 1.597 -0.253
ENSG00000166140 E003 69.454515 0.0122615888 7.130237e-01 0.8436765279 15 40807234 40807413 180 + 1.782 1.785 0.009
ENSG00000166140 E004 28.039745 0.2933927615 3.822969e-01 0.6140723892 15 40807414 40807421 8 + 1.320 1.421 0.351
ENSG00000166140 E005 65.456192 0.0431259122 2.412091e-01 0.4779479749 15 40807422 40807589 168 + 1.684 1.779 0.324
ENSG00000166140 E006 40.550803 0.0011319625 8.824634e-02 0.2604856034 15 40807590 40807641 52 + 1.484 1.582 0.336
ENSG00000166140 E007 34.448204 0.0016703768 2.512781e-01 0.4893613452 15 40807642 40807659 18 + 1.441 1.509 0.233
ENSG00000166140 E008 27.296619 0.0023054784 4.683198e-01 0.6789189428 15 40807660 40807671 12 + 1.364 1.407 0.151
ENSG00000166140 E009 24.361744 0.0107983082 8.135078e-01 0.9043455030 15 40807672 40807676 5 + 1.341 1.351 0.035
ENSG00000166140 E010 23.683393 0.0113224428 9.425889e-01 0.9735810202 15 40807677 40807722 46 + 1.341 1.336 -0.016
ENSG00000166140 E011 2.434383 0.0323216926 2.533751e-01 0.4916018302 15 40807723 40807733 11 + 0.329 0.550 1.165
ENSG00000166140 E012 2.868493 0.0963759633 2.085153e-01 0.4400789812 15 40807734 40807734 1 + 0.329 0.606 1.417
ENSG00000166140 E013 11.282144 0.0762885880 2.715200e-01 0.5113771593 15 40807735 40807756 22 + 0.892 1.072 0.668
ENSG00000166140 E014 23.309285 0.0017635412 4.199691e-01 0.6436283967 15 40807757 40807762 6 + 1.282 1.337 0.191
ENSG00000166140 E015 27.397956 0.0015397015 3.331531e-01 0.5717662420 15 40807763 40807767 5 + 1.342 1.405 0.217
ENSG00000166140 E016 45.861470 0.0029298584 1.320116e-01 0.3349811241 15 40807768 40807791 24 + 1.537 1.621 0.284
ENSG00000166140 E017 56.494472 0.0050818428 2.338518e-01 0.4695989736 15 40807792 40807821 30 + 1.645 1.705 0.204
ENSG00000166140 E018 68.437318 0.0070920153 4.883476e-01 0.6928781110 15 40807822 40807868 47 + 1.753 1.778 0.086
ENSG00000166140 E019 19.127394 0.0020283725 1.479514e-03 0.0134699791 15 40808044 40808075 32 + 1.433 1.158 -0.962
ENSG00000166140 E020 35.135305 0.0750307634 9.129762e-02 0.2660661638 15 40808121 40808254 134 + 1.657 1.427 -0.788
ENSG00000166140 E021 35.059704 0.0479281740 1.870869e-02 0.0914239557 15 40808255 40808378 124 + 1.686 1.408 -0.949
ENSG00000166140 E022 83.166958 0.0198799543 8.550121e-04 0.0087323020 15 40808379 40808918 540 + 2.045 1.778 -0.900
ENSG00000166140 E023 32.264275 0.0424096331 1.539724e-01 0.3679974360 15 40808919 40809012 94 + 1.584 1.406 -0.610
ENSG00000166140 E024 31.858672 0.0358098017 1.665303e-01 0.3859157706 15 40809013 40809118 106 + 1.570 1.405 -0.567
ENSG00000166140 E025 73.986053 0.0088265810 4.148753e-01 0.6397298376 15 40809119 40809155 37 + 1.782 1.814 0.110
ENSG00000166140 E026 107.638228 0.0044005277 1.234346e-01 0.3211835513 15 40809156 40809240 85 + 1.923 1.984 0.204
ENSG00000166140 E027 17.591033 0.0627774568 2.485696e-02 0.1117923450 15 40809241 40809407 167 + 1.428 1.099 -1.159
ENSG00000166140 E028 98.638911 0.0042304411 6.986437e-01 0.8347453387 15 40809408 40809458 51 + 1.930 1.935 0.019
ENSG00000166140 E029 156.432771 0.0021488633 6.390902e-01 0.7962979180 15 40809852 40809970 119 + 2.157 2.124 -0.110
ENSG00000166140 E030 6.028637 0.0703545254 1.280900e-01 0.3287634051 15 40809971 40810070 100 + 0.981 0.712 -1.044
ENSG00000166140 E031 78.165585 0.0024799758 4.260466e-01 0.6480412475 15 40810071 40810080 10 + 1.817 1.844 0.090
ENSG00000166140 E032 154.487962 0.0023388827 1.387103e-01 0.3455608871 15 40810081 40810216 136 + 2.095 2.139 0.148
ENSG00000166140 E033 139.159183 0.0004229287 1.668967e-01 0.3864168264 15 40810649 40810757 109 + 2.058 2.093 0.116
ENSG00000166140 E034 15.925029 0.0760248705 3.752658e-05 0.0006534273 15 40810758 40811074 317 + 1.548 0.921 -2.224
ENSG00000166140 E035 95.269213 0.0005202811 7.062730e-01 0.8395217463 15 40812699 40812902 204 + 1.917 1.919 0.006
ENSG00000166140 E036 6.830086 0.0601538586 1.489213e-01 0.3607580251 15 40813323 40813337 15 + 1.002 0.764 -0.910
ENSG00000166140 E037 112.673016 0.0009150869 4.851418e-01 0.6906839998 15 40813338 40813417 80 + 1.981 1.994 0.044
ENSG00000166140 E038 14.316452 0.0185023781 4.405633e-01 0.6591387553 15 40813418 40813662 245 + 1.197 1.094 -0.366
ENSG00000166140 E039 14.436486 0.0022564468 7.686230e-01 0.8777919220 15 40813663 40813712 50 + 1.165 1.123 -0.148
ENSG00000166140 E040 99.273864 0.0005865137 3.373469e-01 0.5757177941 15 40813713 40813811 99 + 1.917 1.943 0.087
ENSG00000166140 E041 99.300388 0.0013878973 4.513505e-01 0.6666117949 15 40813943 40814070 128 + 1.926 1.945 0.065
ENSG00000166140 E042 52.062917 0.0008045657 5.516279e-02 0.1916943431 15 40814071 40814147 77 + 1.748 1.632 -0.395
ENSG00000166140 E043 85.670475 0.0037623587 2.268458e-01 0.4615576819 15 40814148 40814212 65 + 1.838 1.883 0.150
ENSG00000166140 E044 161.618562 0.0003059684 4.838011e-02 0.1758901799 15 40814213 40815084 872 + 2.111 2.161 0.167