ENSG00000166024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298999 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding protein_coding 7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 1.0271019 0.07119824 1.0968737 0.07119824 0.6188589 3.7688983 0.13036667 0.01286667 0.12526667 1.124000e-01 6.731984e-01 2.152599e-15 FALSE TRUE
ENST00000314594 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding protein_coding 7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 0.7339034 0.89204553 0.0000000 0.09359754 0.0000000 -6.4951284 0.11246667 0.19556667 0.00000000 -1.955667e-01 2.152599e-15 2.152599e-15 FALSE TRUE
ENST00000370584 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding protein_coding 7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 0.5548500 0.00000000 1.0257922 0.00000000 0.4801844 6.6945908 0.06773333 0.00000000 0.11120000 1.112000e-01 5.310566e-03 2.152599e-15 FALSE TRUE
ENST00000613938 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding protein_coding 7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 0.9717264 1.43501917 0.0000000 0.71952272 0.0000000 -7.1749448 0.18126250 0.26796667 0.00000000 -2.679667e-01 2.016489e-01 2.152599e-15 FALSE TRUE
MSTRG.4463.2 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding   7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 0.5361590 0.00000000 0.5691396 0.00000000 0.2953240 5.8558394 0.06387917 0.00000000 0.06500000 6.500000e-02 4.248336e-01 2.152599e-15 FALSE TRUE
MSTRG.4463.3 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding   7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 1.8968142 0.70662655 4.4332325 0.35667916 0.6915504 2.6323162 0.22470833 0.17230000 0.47220000 2.999000e-01 5.467181e-01 2.152599e-15 FALSE TRUE
MSTRG.4463.4 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding   7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 0.3460818 0.37468619 0.1195638 0.37468619 0.1195638 -1.5700194 0.05935833 0.11350000 0.01366667 -9.983333e-02 9.807479e-01 2.152599e-15 FALSE TRUE
MSTRG.4463.6 ENSG00000166024 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HCC1L protein_coding   7.359605 4.669666 9.336142 0.6926362 0.5812838 0.9979654 0.7814518 0.97756498 1.7941390 0.52881802 1.0786679 0.8693629 0.09370417 0.18130000 0.18136667 6.666667e-05 1.000000e+00 2.152599e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166024 E001 0.0000000       10 98134624 98134640 17 +      
ENSG00000166024 E002 0.0000000       10 98134641 98134641 1 +      
ENSG00000166024 E003 0.1426347 0.0317016562 1.000000e+00   10 98134642 98134656 15 + 0.080 0.000 -8.685
ENSG00000166024 E004 0.6081007 0.0217681645 1.520812e-01   10 98134657 98134666 10 + 0.258 0.000 -12.492
ENSG00000166024 E005 11.2951615 0.0031680721 8.668833e-05 1.326277e-03 10 98134667 98134706 40 + 1.134 0.748 -1.454
ENSG00000166024 E006 0.6300180 0.5715956112 5.923831e-01   10 98134907 98135024 118 + 0.145 0.311 1.405
ENSG00000166024 E007 0.0000000       10 98152813 98152818 6 +      
ENSG00000166024 E008 0.2027342 0.0323644004 2.437234e-01   10 98152819 98152852 34 + 0.000 0.180 11.876
ENSG00000166024 E009 0.3807181 0.0296546802 6.120633e-01   10 98153910 98154033 124 + 0.080 0.180 1.332
ENSG00000166024 E010 5.4889361 0.0057175694 6.300205e-01 7.904264e-01 10 98156093 98156147 55 + 0.769 0.787 0.068
ENSG00000166024 E011 18.6519713 0.0097112953 4.443289e-03 3.162236e-02 10 98162883 98162975 93 + 1.296 1.106 -0.674
ENSG00000166024 E012 0.0000000       10 98163287 98163292 6 +      
ENSG00000166024 E013 25.3380133 0.0168483734 1.700914e-02 8.548929e-02 10 98163293 98163397 105 + 1.411 1.277 -0.465
ENSG00000166024 E014 12.7662521 0.0030342216 1.523364e-01 3.657505e-01 10 98186467 98186563 97 + 1.107 1.051 -0.204
ENSG00000166024 E015 97.5814878 0.0006194921 1.115376e-10 7.836844e-09 10 98208101 98208750 650 + 1.991 1.836 -0.523
ENSG00000166024 E016 181.4911439 0.0033145118 5.006633e-03 3.466129e-02 10 98208751 98209757 1007 + 2.216 2.222 0.019
ENSG00000166024 E017 52.3736507 0.0283439705 9.918938e-01 9.976727e-01 10 98209758 98209899 142 + 1.654 1.749 0.321
ENSG00000166024 E018 0.3206185 0.0274001847 4.668735e-01   10 98211307 98211348 42 + 0.148 0.000 -11.523
ENSG00000166024 E019 60.5384406 0.0239810097 6.612435e-01 8.107135e-01 10 98231512 98231687 176 + 1.727 1.787 0.204
ENSG00000166024 E020 43.5680958 0.0055120020 3.873732e-01 6.184068e-01 10 98234446 98234516 71 + 1.552 1.705 0.521
ENSG00000166024 E021 50.2649185 0.0160674552 2.422958e-01 4.791211e-01 10 98235425 98235520 96 + 1.597 1.796 0.675
ENSG00000166024 E022 59.4390013 0.0352012765 6.602762e-02 2.161836e-01 10 98236024 98236164 141 + 1.641 1.913 0.918
ENSG00000166024 E023 126.3777466 1.3945791960 3.434540e-01 5.811253e-01 10 98244091 98244897 807 + 1.907 2.304 1.331