ENSG00000166004

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325212 ENSG00000166004 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP295 protein_coding protein_coding 5.777141 2.866024 10.72086 0.1137646 0.3784354 1.899618 1.2167151 0.7574326 2.0861113 0.4007175 0.38670520 1.4496033 0.19637917 0.2674000 0.19516667 -0.07223333 1.000000000 0.000113958 FALSE TRUE
ENST00000530425 ENSG00000166004 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP295 protein_coding protein_coding 5.777141 2.866024 10.72086 0.1137646 0.3784354 1.899618 0.3336235 0.0000000 0.4905889 0.0000000 0.09402248 5.6455543 0.05059583 0.0000000 0.04540000 0.04540000 0.005162039 0.000113958 FALSE TRUE
ENST00000531404 ENSG00000166004 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP295 protein_coding protein_coding 5.777141 2.866024 10.72086 0.1137646 0.3784354 1.899618 0.8446113 0.6715492 1.0550143 0.1115397 0.21709546 0.6439832 0.20328750 0.2363667 0.09736667 -0.13900000 0.146152164 0.000113958 FALSE TRUE
ENST00000531700 ENSG00000166004 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP295 protein_coding protein_coding 5.777141 2.866024 10.72086 0.1137646 0.3784354 1.899618 0.8633293 0.9175903 1.3825033 0.1257524 0.28943122 0.5861212 0.20237083 0.3220000 0.12976667 -0.19223333 0.083651084 0.000113958 FALSE TRUE
MSTRG.6180.5 ENSG00000166004 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP295 protein_coding   5.777141 2.866024 10.72086 0.1137646 0.3784354 1.899618 0.7093728 0.0000000 1.7483263 0.0000000 0.57951405 7.4580590 0.08025417 0.0000000 0.16470000 0.16470000 0.000113958 0.000113958 FALSE TRUE
MSTRG.6180.9 ENSG00000166004 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP295 protein_coding   5.777141 2.866024 10.72086 0.1137646 0.3784354 1.899618 1.1428856 0.3421124 2.6599649 0.3421124 0.44780045 2.9227130 0.16591667 0.1147667 0.24843333 0.13366667 0.424526590 0.000113958 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000166004 E001 2.4343011 0.014422255 0.2976753517 0.538183574 11 93661658 93661660 3 + 0.488 0.362 -0.673
ENSG00000166004 E002 2.4343011 0.014422255 0.2976753517 0.538183574 11 93661661 93661666 6 + 0.488 0.362 -0.673
ENSG00000166004 E003 3.0424017 0.007835874 0.1324977543 0.335748099 11 93661667 93661681 15 + 0.570 0.362 -1.060
ENSG00000166004 E004 5.2134235 0.058156612 0.1327807389 0.336159207 11 93661682 93661705 24 + 0.740 0.558 -0.784
ENSG00000166004 E005 14.8358865 0.086231450 0.0814532759 0.247723628 11 93661706 93661774 69 + 1.140 0.947 -0.705
ENSG00000166004 E006 25.8621273 0.061000046 0.0075344303 0.047185144 11 93666682 93666815 134 + 1.380 1.118 -0.923
ENSG00000166004 E007 33.5608422 0.070280026 0.0575036517 0.197171674 11 93667607 93667807 201 + 1.471 1.340 -0.452
ENSG00000166004 E008 21.9185291 0.077677110 0.0591586330 0.200896892 11 93668808 93668932 125 + 1.298 1.124 -0.618
ENSG00000166004 E009 16.4307495 0.061346592 0.0158782926 0.081348732 11 93669677 93669770 94 + 1.194 0.939 -0.926
ENSG00000166004 E010 0.3559677 0.950238456 1.0000000000   11 93672043 93672093 51 + 0.125 0.000 -8.476
ENSG00000166004 E011 21.8729588 0.078655726 0.0252785194 0.113057648 11 93675571 93675666 96 + 1.306 1.059 -0.880
ENSG00000166004 E012 9.7577197 0.188872413 0.3671667175 0.601686305 11 93679412 93679415 4 + 0.961 0.847 -0.431
ENSG00000166004 E013 30.0124646 0.080493622 0.0396767069 0.153897461 11 93679416 93679552 137 + 1.432 1.226 -0.716
ENSG00000166004 E014 33.0243106 0.093783207 0.0122374554 0.067382186 11 93683559 93683742 184 + 1.485 1.183 -1.054
ENSG00000166004 E015 24.6419809 0.046996312 0.1084515416 0.296464589 11 93683964 93684128 165 + 1.334 1.251 -0.292
ENSG00000166004 E016 31.5036861 0.079661025 0.0813644519 0.247546586 11 93687644 93687865 222 + 1.442 1.319 -0.427
ENSG00000166004 E017 0.0000000       11 93691681 93691682 2 +      
ENSG00000166004 E018 14.6110660 0.021209824 0.0163978710 0.083263138 11 93691683 93691704 22 + 1.139 0.944 -0.714
ENSG00000166004 E019 21.2143147 0.091336383 0.0505036845 0.180835945 11 93691705 93691775 71 + 1.290 1.093 -0.701
ENSG00000166004 E020 27.2005622 0.116872816 0.0780951428 0.241024106 11 93691927 93692030 104 + 1.389 1.219 -0.596
ENSG00000166004 E021 21.4237577 0.063099907 0.0362834100 0.144996177 11 93695497 93695529 33 + 1.292 1.116 -0.625
ENSG00000166004 E022 25.2263942 0.080570142 0.0168475570 0.084889113 11 93695530 93695634 105 + 1.369 1.117 -0.889
ENSG00000166004 E023 9.9967667 0.141034176 0.0110750878 0.062678399 11 93695635 93695673 39 + 1.015 0.557 -1.841
ENSG00000166004 E024 18.5157090 0.049105001 0.0009145880 0.009215503 11 93696320 93696417 98 + 1.257 0.872 -1.407
ENSG00000166004 E025 25.2689460 0.001764176 0.0004372927 0.005101838 11 93696682 93696854 173 + 1.374 1.166 -0.728
ENSG00000166004 E026 14.3042800 0.415211632 0.8488440937 0.924274505 11 93696855 93696937 83 + 1.099 1.089 -0.035
ENSG00000166004 E027 161.1394995 1.452547694 0.6962942688 0.833164534 11 93696938 93698907 1970 + 2.102 2.160 0.192
ENSG00000166004 E028 70.5365866 0.885455500 0.5633061122 0.745601317 11 93698908 93699574 667 + 1.736 1.846 0.374
ENSG00000166004 E029 61.4354108 0.223960500 0.4357334687 0.655530243 11 93699575 93700186 612 + 1.669 1.813 0.488
ENSG00000166004 E030 32.5193597 0.001132688 0.3996653129 0.627982628 11 93702460 93702637 178 + 1.429 1.481 0.179
ENSG00000166004 E031 24.6927372 0.001526070 0.3706000165 0.604402253 11 93702776 93702919 144 + 1.315 1.352 0.130
ENSG00000166004 E032 40.4687915 0.041381288 0.8958631191 0.949706061 11 93706745 93706897 153 + 1.490 1.637 0.500
ENSG00000166004 E033 35.9804921 0.022383004 0.8564252245 0.928479232 11 93721312 93721412 101 + 1.442 1.592 0.514
ENSG00000166004 E034 37.0820106 0.029268652 0.9087303465 0.956446421 11 93721954 93722050 97 + 1.455 1.605 0.511
ENSG00000166004 E035 7.0889116 0.094902547 0.3392666101 0.577339459 11 93722502 93723040 539 + 0.739 1.060 1.225
ENSG00000166004 E036 25.5775873 0.043691513 0.8367533307 0.917673854 11 93723041 93723052 12 + 1.310 1.425 0.399
ENSG00000166004 E037 60.6595642 0.033566287 0.8148972769 0.905186710 11 93723053 93723289 237 + 1.671 1.788 0.398
ENSG00000166004 E038 4.4124792 0.249248073 0.7989066460 0.895648948 11 93723399 93724253 855 + 0.594 0.838 1.011
ENSG00000166004 E039 41.3902858 0.026341165 0.6359347746 0.794248499 11 93724254 93724375 122 + 1.492 1.666 0.592
ENSG00000166004 E040 49.7568835 0.003509733 0.4577542308 0.671612662 11 93725651 93725831 181 + 1.577 1.737 0.542
ENSG00000166004 E041 112.5814816 1.228117371 0.3294468939 0.568417811 11 93726976 93727637 662 + 1.856 2.227 1.245
ENSG00000166004 E042 40.3932788 0.644443244 0.1923432910 0.419892980 11 93728681 93728821 141 + 1.405 1.815 1.398
ENSG00000166004 E043 32.3356024 0.561015360 0.2099311695 0.441757320 11 93729434 93729530 97 + 1.331 1.691 1.235
ENSG00000166004 E044 6.3134876 0.097658693 0.1172568348 0.311230844 11 93729611 93729613 3 + 0.690 1.038 1.343
ENSG00000166004 E045 45.2185603 0.635681758 0.1350709962 0.339823044 11 93729614 93729781 168 + 1.426 1.899 1.607
ENSG00000166004 E046 39.3178757 0.294979890 0.0452708715 0.168277694 11 93729870 93729969 100 + 1.356 1.855 1.702
ENSG00000166004 E047 38.6684152 0.551761522 0.0958430030 0.274492168 11 93730049 93730148 100 + 1.345 1.854 1.737
ENSG00000166004 E048 20.4996771 0.375295784 0.1048855178 0.290437863 11 93730231 93730358 128 + 1.106 1.561 1.589