ENSG00000165915

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354884 ENSG00000165915 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A13 protein_coding protein_coding 24.91167 36.76987 15.60544 4.753527 0.7533744 -1.235943 8.427636 11.706162 5.6656983 1.8468238 0.27325557 -1.04563025 0.33276250 0.31580000 0.363666667 0.04786667 0.646734483 0.001756841 FALSE TRUE
ENST00000362021 ENSG00000165915 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A13 protein_coding protein_coding 24.91167 36.76987 15.60544 4.753527 0.7533744 -1.235943 6.596498 11.644531 1.9092836 2.3063458 0.20481334 -2.60225109 0.24599583 0.31080000 0.123000000 -0.18780000 0.001756841 0.001756841 FALSE TRUE
ENST00000524928 ENSG00000165915 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A13 protein_coding protein_coding 24.91167 36.76987 15.60544 4.753527 0.7533744 -1.235943 2.373612 3.001527 2.0343266 0.6139917 0.05324285 -0.55886963 0.10572917 0.08800000 0.130666667 0.04266667 0.631240340 0.001756841 FALSE TRUE
ENST00000527829 ENSG00000165915 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A13 protein_coding processed_transcript 24.91167 36.76987 15.60544 4.753527 0.7533744 -1.235943 1.601141 2.872393 0.1351442 0.6774591 0.13514420 -4.31170844 0.05437083 0.07616667 0.009466667 -0.06670000 0.143892715 0.001756841   FALSE
ENST00000528979 ENSG00000165915 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A13 protein_coding processed_transcript 24.91167 36.76987 15.60544 4.753527 0.7533744 -1.235943 1.211204 1.743620 1.2280562 0.2313169 0.27156149 -0.50225920 0.05325833 0.04903333 0.077366667 0.02833333 0.623307717 0.001756841 FALSE FALSE
ENST00000531974 ENSG00000165915 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A13 protein_coding protein_coding 24.91167 36.76987 15.60544 4.753527 0.7533744 -1.235943 2.415293 2.777217 2.9530480 0.6974102 0.48008114 0.08825659 0.11027917 0.08066667 0.188100000 0.10743333 0.246587628 0.001756841 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165915 E001 0.1308682 0.0326491905 1.000000000   11 47407132 47407533 402 + 0.000 0.073 8.269
ENSG00000165915 E002 0.7677130 0.0176237589 0.205833706   11 47408533 47408583 51 + 0.000 0.281 12.870
ENSG00000165915 E003 0.5953387 0.0252201127 0.306334017   11 47408584 47408584 1 + 0.000 0.237 12.452
ENSG00000165915 E004 0.5953387 0.0252201127 0.306334017   11 47408585 47408589 5 + 0.000 0.237 12.452
ENSG00000165915 E005 8.1272274 0.0338926005 0.228819077 0.46382991 11 47408590 47408604 15 + 0.746 0.954 0.807
ENSG00000165915 E006 30.5316439 0.0060114865 0.053649799 0.18823332 11 47408605 47408627 23 + 1.309 1.478 0.585
ENSG00000165915 E007 32.1085762 0.0055662744 0.023278195 0.10682579 11 47408628 47408630 3 + 1.309 1.503 0.672
ENSG00000165915 E008 70.7295800 0.0040869739 0.035682605 0.14340173 11 47408631 47408662 32 + 1.694 1.823 0.435
ENSG00000165915 E009 0.3206185 0.0274424043 0.032913817   11 47409591 47409663 73 + 0.331 0.000 -14.200
ENSG00000165915 E010 0.0000000       11 47409821 47409965 145 +      
ENSG00000165915 E011 0.0000000       11 47410066 47410084 19 +      
ENSG00000165915 E012 0.7095188 0.1814710271 0.326007064   11 47410085 47410086 2 + 0.329 0.138 -1.601
ENSG00000165915 E013 226.7513843 0.0028291315 0.809721932 0.90200269 11 47410087 47410395 309 + 2.284 2.296 0.040
ENSG00000165915 E014 140.7873453 0.0003403719 0.217825674 0.45084718 11 47411926 47412039 114 + 2.119 2.080 -0.130
ENSG00000165915 E015 26.3637354 0.0899911947 0.002536924 0.02057441 11 47412040 47412301 262 + 1.678 1.201 -1.650
ENSG00000165915 E016 10.1520277 0.0738941865 0.003519690 0.02646203 11 47412302 47412345 44 + 1.291 0.810 -1.765
ENSG00000165915 E017 127.2713014 0.0007316741 0.062050805 0.20738106 11 47412346 47412467 122 + 1.988 2.061 0.245
ENSG00000165915 E018 134.0987038 0.9569372233 0.373614997 0.60703427 11 47413400 47413507 108 + 1.884 2.105 0.741
ENSG00000165915 E019 141.7202166 0.0486456120 0.286414104 0.52708252 11 47413597 47413686 90 + 2.019 2.105 0.291
ENSG00000165915 E020 33.0896827 0.0605551928 0.216313947 0.44906219 11 47413687 47413880 194 + 1.580 1.422 -0.540
ENSG00000165915 E021 65.4367541 0.0590125859 0.024489256 0.11063390 11 47413881 47414295 415 + 1.938 1.677 -0.880
ENSG00000165915 E022 44.1954642 0.0444180227 0.008645842 0.05224881 11 47414296 47414424 129 + 1.794 1.494 -1.020
ENSG00000165915 E023 108.1503518 0.0004543220 0.367365112 0.60187460 11 47414425 47414436 12 + 2.001 1.968 -0.111
ENSG00000165915 E024 121.0295019 0.0004808334 0.145861687 0.35615518 11 47414437 47414475 39 + 2.063 2.011 -0.172
ENSG00000165915 E025 17.4794479 0.1020744090 0.389653070 0.62020207 11 47414476 47414776 301 + 1.284 1.171 -0.398
ENSG00000165915 E026 140.6128939 0.0013974937 0.405258556 0.63249822 11 47414777 47414861 85 + 2.107 2.076 -0.106
ENSG00000165915 E027 90.1646110 0.0005323506 0.791361135 0.89123642 11 47414862 47414905 44 + 1.886 1.900 0.047
ENSG00000165915 E028 64.4376231 0.0044125899 0.616489173 0.78138045 11 47414906 47414909 4 + 1.772 1.749 -0.078
ENSG00000165915 E029 11.3229738 0.0032931664 0.415714084 0.64032909 11 47414910 47415038 129 + 0.953 1.050 0.356
ENSG00000165915 E030 4.9950793 0.1063945929 0.520950029 0.71552787 11 47415039 47415059 21 + 0.789 0.678 -0.452
ENSG00000165915 E031 139.5949805 0.0009407514 0.545699787 0.73322553 11 47415060 47415159 100 + 2.098 2.078 -0.067
ENSG00000165915 E032 36.4139670 0.0054620062 0.566343120 0.74754966 11 47415160 47415287 128 + 1.471 1.513 0.146
ENSG00000165915 E033 211.8796616 0.0005815892 0.594458702 0.76664070 11 47415288 47415496 209 + 2.272 2.258 -0.046
ENSG00000165915 E034 562.3526272 0.0014622410 0.037484952 0.14826615 11 47415497 47416324 828 + 2.648 2.694 0.154
ENSG00000165915 E035 110.7801931 0.0010783088 0.600998378 0.77084792 11 47416325 47416496 172 + 1.998 1.980 -0.063