ENSG00000165905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325468 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding protein_coding 7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 0.9466847 0.5533718 0.4821280 0.3370999 0.2410647 -0.1950536 0.14139583 0.06043333 0.13863333 0.07820000 9.293640e-01 4.441463e-12 FALSE TRUE
ENST00000401752 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding protein_coding 7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 0.9946718 1.7777594 0.0000000 0.3115814 0.0000000 -7.4820088 0.13164167 0.21526667 0.00000000 -0.21526667 4.441463e-12 4.441463e-12 FALSE TRUE
ENST00000414027 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding retained_intron 7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 1.6283928 1.8127481 1.4073456 0.2314228 0.3159939 -0.3629237 0.24585833 0.22050000 0.34216667 0.12166667 4.858349e-01 4.441463e-12 FALSE FALSE
ENST00000525609 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding retained_intron 7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 0.4117877 0.4711943 0.4359692 0.0617491 0.1972048 -0.1096755 0.06492083 0.06003333 0.09773333 0.03770000 7.293534e-01 4.441463e-12 FALSE FALSE
ENST00000528236 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding retained_intron 7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 0.7665951 0.9430431 0.8704526 0.2041614 0.1949431 -0.1142962 0.12651667 0.12016667 0.22783333 0.10766667 6.612662e-01 4.441463e-12 TRUE TRUE
ENST00000531847 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding protein_coding 7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 0.9878812 0.7755504 0.1224271 0.1319900 0.1224271 -2.5685058 0.12044167 0.09473333 0.02370000 -0.07103333 3.465125e-01 4.441463e-12 FALSE FALSE
MSTRG.5441.5 ENSG00000165905 HEK293_OSMI2_6hA HEK293_TMG_6hB LARGE2 protein_coding   7.012632 8.18157 4.142809 0.8511986 0.6693265 -0.9800526 0.6915683 0.9447557 0.4328452 0.1377706 0.2171338 -1.1083291 0.09291250 0.11506667 0.09096667 -0.02410000 8.713988e-01 4.441463e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165905 E001 0.2027342 0.055717955 1.000000000   11 45921621 45921644 24 + 0.000 0.077 8.433
ENSG00000165905 E002 0.3751086 0.029729226 0.667368092   11 45921645 45921693 49 + 0.000 0.143 9.430
ENSG00000165905 E003 2.5362333 0.027041692 0.004609431 0.03252129 11 45922656 45922728 73 + 0.000 0.611 12.419
ENSG00000165905 E004 1.4103551 0.012945726 0.782641570 0.88619238 11 45922778 45922820 43 + 0.317 0.372 0.333
ENSG00000165905 E005 5.1075938 0.015348412 0.342563033 0.58025304 11 45922821 45922964 144 + 0.626 0.780 0.639
ENSG00000165905 E006 3.8215173 0.008603693 0.273764260 0.51369517 11 45922965 45923057 93 + 0.498 0.687 0.847
ENSG00000165905 E007 9.3991184 0.005644001 0.048311758 0.17574055 11 45923058 45923167 110 + 0.766 1.028 0.999
ENSG00000165905 E008 16.6344307 0.002061085 0.129107131 0.33037037 11 45923473 45923555 83 + 1.089 1.237 0.527
ENSG00000165905 E009 2.0657591 0.045511418 0.013146523 0.07104025 11 45924150 45924153 4 + 0.724 0.294 -2.154
ENSG00000165905 E010 29.4951904 0.001225731 0.422011063 0.64515187 11 45924154 45924277 124 + 1.477 1.424 -0.183
ENSG00000165905 E011 3.1016781 0.008402141 0.018470767 0.09060301 11 45924454 45924505 52 + 0.804 0.439 -1.620
ENSG00000165905 E012 36.1916891 0.001199332 0.961346309 0.98268114 11 45924506 45924616 111 + 1.528 1.527 -0.004
ENSG00000165905 E013 30.1420506 0.001373877 0.354170990 0.59099143 11 45924617 45924677 61 + 1.401 1.469 0.234
ENSG00000165905 E014 16.5459876 0.002006071 0.160576757 0.37764247 11 45924678 45924784 107 + 1.285 1.163 -0.431
ENSG00000165905 E015 42.4831893 0.001011812 0.805824962 0.89959711 11 45924785 45924889 105 + 1.580 1.596 0.055
ENSG00000165905 E016 24.4482602 0.001991225 0.546880077 0.73407346 11 45926039 45926151 113 + 1.319 1.367 0.165
ENSG00000165905 E017 7.7253565 0.042958619 0.300953163 0.54144087 11 45926152 45926221 70 + 1.004 0.855 -0.563
ENSG00000165905 E018 38.2936324 0.002335997 0.257865201 0.49661422 11 45926222 45926347 126 + 1.592 1.521 -0.245
ENSG00000165905 E019 0.6592102 0.070449935 0.331020419   11 45926363 45926441 79 + 0.318 0.142 -1.482
ENSG00000165905 E020 16.5982152 0.002355363 0.113601885 0.30515514 11 45926442 45926450 9 + 1.296 1.157 -0.492
ENSG00000165905 E021 34.8015293 0.001045264 0.006771702 0.04357181 11 45926451 45926597 147 + 1.621 1.458 -0.560
ENSG00000165905 E022 32.9564541 0.001238671 0.147468631 0.35871325 11 45926711 45926871 161 + 1.549 1.458 -0.312
ENSG00000165905 E023 29.1235464 0.001276751 0.445743525 0.66257325 11 45927315 45927444 130 + 1.391 1.448 0.197
ENSG00000165905 E024 39.1471366 0.001036728 0.032837316 0.13559722 11 45927445 45927593 149 + 1.453 1.592 0.476
ENSG00000165905 E025 5.9397364 0.125958395 0.479968519 0.68708016 11 45927749 45927919 171 + 0.873 0.757 -0.455
ENSG00000165905 E026 27.5812708 0.006042417 0.051344603 0.18294821 11 45927920 45928035 116 + 1.285 1.453 0.584
ENSG00000165905 E027 17.8099268 0.002264156 0.553698480 0.73885779 11 45928036 45928069 34 + 1.190 1.246 0.197
ENSG00000165905 E028 41.1257114 0.001516896 0.773625167 0.88089516 11 45928177 45928372 196 + 1.586 1.570 -0.054
ENSG00000165905 E029 49.8702848 0.001497797 0.454341964 0.66898903 11 45928630 45929096 467 + 1.621 1.664 0.145